Myocardial Tissue Characterization: An Approach Based on Quantitative Backscatter and Attenuation

Miller, James G.; Pérez, Julio E.; Mottley, Jack G.; Madaras, Eric I.; Johnston, Patrick H.; Blodgett, Earl D.; Thomas, Lewis J.; Sobel, Burton E.

doi:10.1109/ultsym.1983.198167

Cited by 63 publications

(23 citation statements)

References 36 publications

(1 reference statement)

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“…9 QUS techniques have been used to detect and classify different kinds of cancer in vivo. [10][11][12][13] Parameterization of the backscattered rf signals through the normalized backscattered power spectra have allowed the correlation of ultrasonic signals to underlying tissue morphology (subwavelength). 13,14 Specifically, parameters such as the effective scatterer diameter (ESD) have been related to the size of dominant scatterers in tissues and the effective acoustic concentration (EAC) have been related to the density of structures responsible for scattering.…”

Section: Introductionmentioning

confidence: 99%

Temperature dependent ultrasonic characterization of biological media

Ghoshal

Luchies

Blue

et al. 2011

The Journal of the Acoustical Society of America

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Quantitative ultrasound (QUS) is an imaging technique that can be used to quantify tissue microstructure giving rise to scattered ultrasound. Other ultrasonic properties, e.g., sound speed and attenuation, of tissues have been estimated versus temperature elevation and found to have a dependence with temperature. Therefore, it is hypothesized that QUS parameters may be sensitive to changes in tissue microstructure due to temperature elevation. Ultrasonic backscatter experiments were performed on tissue-mimicking phantoms and freshly excised rabbit and beef liver samples. The phantoms were made of agar and contained either mouse mammary carcinoma cells (4T1) or chinese hamster ovary cells (CHO) as scatterers. All scatterers were uniformly distributed spatially at random throughout the phantoms. All the samples were scanned using a 20-MHz single-element f/3 transducer. Quantitative ultrasound parameters were estimated from the samples versus increases in temperature from 37C to 50 C in 1 C increments. Two QUS parameters were estimated from the backscatter coefficient [effective scatterer diameter (ESD) and effective acoustic concentration (EAC)] using a spherical Gaussian scattering model. Significant increases in ESD and decreases in EAC of 20%-40% were observed in the samples over the range of temperatures examined. The results of this study indicate that QUS parameters are sensitive to changes in temperature. Gaussian scattering model k wavelength Z 0 acoustic impedance of the surrounding medium Z acoustic impedance of the scatterers q density of the sample

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Section: Introductionmentioning

confidence: 99%

Temperature dependent ultrasonic characterization of biological media

Ghoshal

Luchies

Blue

et al. 2011

The Journal of the Acoustical Society of America

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“…Visual inspection ofthe raw rfdata revealed greater scattering in the perpendicular direction for all transmural sections. (23,24). By replacing the scattering material in the water tank with a reflector of known properties positioned at the focal point ofthe transducer, we can obtain a reference power spectrum IE.4f)12 = Ip(f)121RM(f) 1 2 determined only by the transducer power spectrum, p(f) 2, and the reflection coefficient of the planar reflector, Rg f).…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional characterization of human ventricular myofiber architecture by ultrasonic backscatter.

Wickline¹,

Verdonk²,

Miller³

1991

J. Clin. Invest.

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“…It has been shown previously that integrated backscatter levels in acute ischemic myocardial tissue are higher as compared to integrated backscatter levels measured in normal myocardium (O'Donnell et al 1979;Miller et al 1983;Glueck et al 1985;Rijsterborgh et al 1990).…”

Section: Introductionmentioning

confidence: 79%

“…A well-known feature of ultrasonic myocardial integrated backscatter is its cyclic variation during the cardiac cycle: in normal myocardium end-diastolic integrated backscatter is higher as compared to endsystolic backscatter levels (Miller et al 1983;Mottley et al 1984;Wickline et al 1985). The cyclic variation suggests an inverse relationship between integrated backscatter measurements and myocardial wall thickness.…”

Section: Introductionmentioning

confidence: 99%

The relative contributions of myocardial wall thickness and ischemia to ultrasonic myocardial integrated backscatter during experimental ischemia

Rijsterborgh

Mastik

Lancée

et al. 1991

Ultrasound in Medicine & Biology

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Abstract--The purpose of this study was to assess the empirical relationship between myocardial integrated backscatter (IB) and myocardial wall thickness (WT) in normal myocardium. A second object was to estimate the additional contribution to acute ischemic integrated backscatter levels given this relationship. Myocardial IB measurements and simultaneous myocardial WT measurements were made in 16 open-chested pigs with intact coronary circulation (normal myocardium) and 10 min after the flow in the left anterior descending coronary artery had been reduced to 20% of its baseline value (ischemic myocardium). Measurements were made 50 times during one cardiac cycle and averaged over 10 cardiac cycles. IB and WT measurements were normalized with respect to the nonischemic end-diastolic values. The relationship between IB and WT in normal myocardium was estimated in every individual pig by simple linear regression. Estimates of IB during iscbemia were calculated on the basis of this relationship and the ischemic WT measurements. Differences of the estimator and the actual measurement made during iscbemia depict the actual contribution of the state of acute ischemia, without the influence of WT. The slope of the relationship between IB and WT during normal myocardial contraction ranged from -0.16 to 0.03 dB/% (mean = -0.036 dB/%, SD = 0.06 dB/%). The additional contribution of ischemia ranged from -3.84 to 5.56 dB (mean = 0.31 dB, SD = 2.72 dB). It was concluded that the average contribution of iscbemia to IB measurements is insignificant if the IB dependency on WT is removed from the data and that the higher level of ischemic IB measurements can be explained by the decrease in wall thickness during ischemia and not by the ischemia itself.

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Myocardial Tissue Characterization: An Approach Based on Quantitative Backscatter and Attenuation

Abstract: Department of P h y s i c s , D i v i s i o n of C a r d i o l o g y , and Biomedical Computer L a b o r a t o r y , Washington U n i v e r s i t y , S t . L o u i s , Misscrhri 63130.

Cited by 63 publications

References 36 publications

Temperature dependent ultrasonic characterization of biological media

Temperature dependent ultrasonic characterization of biological media

Three-dimensional characterization of human ventricular myofiber architecture by ultrasonic backscatter.

The relative contributions of myocardial wall thickness and ischemia to ultrasonic myocardial integrated backscatter during experimental ischemia

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