Three-dimensional characterization of human ventricular myofiber architecture by ultrasonic backscatter.

Wickline, Samuel A.; Verdonk, Edward; Miller, James G.

doi:10.1172/jci115323

Cited by 59 publications

(31 citation statements)

References 32 publications

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“…The anisotropic structure of the LV wall, with fiber directions changing from a right-handed helix in the subendocardium to a left-handed helix in the subepicardium ( Fig. 2A), alters the propagation and backscatter of ultrasonic waves (31)(32)(33). Previous investigations have shown that the integrated backscatter in the LV wall varies approximately as a sinusoidal function of the angle of insonification at each transmural level (31,34).…”

Section: Effect Of Myocardial Anisotropy On Appearance Of Cardiac Ultmentioning

confidence: 94%

“…2A), alters the propagation and backscatter of ultrasonic waves (31)(32)(33). Previous investigations have shown that the integrated backscatter in the LV wall varies approximately as a sinusoidal function of the angle of insonification at each transmural level (31,34). Greater backscatter resulting in a brighter image area is observed when fibers are interrogated by an ultrasound beam that is approximately perpendicular rather than parallel to the direction of the fibers.…”

Section: Effect Of Myocardial Anisotropy On Appearance Of Cardiac Ultmentioning

confidence: 99%

“…2B) (34). Conversely, in short axis views of the LV, bright speckles are seen in the anterior and posterior segments where myofiber sheets are perpendicular to the line of propagation of ultrasonic beam, while prominent attenuation occurs within the midwall of the septum and the lateral segments where the myofiber sheets are relatively parallel (31). A high resolution transducer placed directly over the epicardial surface of a beating heart is used to demonstrate this phenomenon (Supplementary video 1).…”

Section: Effect Of Myocardial Anisotropy On Appearance Of Cardiac Ultmentioning

confidence: 99%

See 2 more Smart Citations

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Sengupta

Krishnamoorthy

Kořínek

et al. 2007

Journal of the American Society of Echocardiography

283

196

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Tissue Doppler imaging (TDI) and TDI-derived strain imaging are robust physiologic tools used for the noninvasive assessment of regional myocardial function. Due to high temporal and spatial resolution, regional function can be assessed for each phase of the cardiac cycle and within the transmural layers of the myocardial wall. Newer techniques that measure myocardial motion by speckle tracking in grayscale images have overcome the angle dependence of TDI strain, allowing for measurement of 2-dimensional strain and cardiac rotation. TDI, TDI strain, and speckle tracking may provide unique information that deciphers the deformation sequence of complexly oriented myofibers in the left ventricular wall. The data are, however, limited. This review examines the structure and function of the left ventricle relative to the potential clinical application of TDI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo.The spiral arrangement of muscle fibers in the heart is reminiscent of spiral and vortex patterns in nature, ranging from small organelles and whirlpools to hurricanes and rotational patterns of the galaxies (1-5). Vortex patterns link two fundamental forms of motion that work in close balance: an inner, rapidly descending swirl and an outer, less rapid, ascending rotation (4) ( Fig. 1 A-C). These counterdirectional movements of a vortex produce suction and expulsion forces that have been exploited for designing energy efficient propellers and turbines (6). Likewise, experimental and mathematical modeling of the clockwise and counterclockwise spiral loops of myofibers in the left ventricle (LV) has shown that counterdirectional geometry provides an efficient distribution of regional stresses and strains (7). Conversely, altered ventricular geometry resulting from cardiac remodeling, regional myocardial dysfunction, or asynchronous conduction distort the efficiency of the loading and expulsion dynamics (8,9). In this review, we associate the LV myofiber architecture to the spatiotemporal sequence of regional deformations occurring during normal cardiac contraction and relaxation. We further elucidate experimental observations, which explore the application of tissue Doppler imaging (TDI) and 2-dimensional ultrasound speckle tracking for delineation of the synchronous mechanical shortening and lengthening sequences of the human LV.Address reprint requests to Marek Belohlavek, Division of Cardiovascular Diseases, Mayo Clinic, 13400 East Shea Boulevard Scottsdale, AZ 85259, E-mail address for author named in reprint line: Belohlavek.marek@mayo.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect th...

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Section: Effect Of Myocardial Anisotropy On Appearance Of Cardiac Ultmentioning

confidence: 94%

Section: Effect Of Myocardial Anisotropy On Appearance Of Cardiac Ultmentioning

confidence: 99%

Section: Effect Of Myocardial Anisotropy On Appearance Of Cardiac Ultmentioning

confidence: 99%

See 1 more Smart Citation

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Sengupta

Krishnamoorthy

Kořínek

et al. 2007

Journal of the American Society of Echocardiography

283

196

View full text Add to dashboard Cite

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“…Ultrasound can also be used to characterize the myocardial structure, through the analysis of backscattered ultrasound. The dependence of backscattered intensity and ultrasound attenuation with fiber orientation was investigated extensively over the past decades [17][18][19][20]. Nevertheless, backscattered intensity depends on many parameters including heterogeneity of the material, presence of bright specular echoes, angle view and period in the cardiac cycle.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound backscatter tensor imaging (BTI): analysis of the spatial coherence of ultrasonic speckle in anisotropic soft tissues

Papadacci

Tanter

Pernot

et al. 2014

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The assessment of fiber architecture is of major interest in the progression of myocardial disease. Recent techniques such as Magnetic Resonance (MR) Diffusion Tensor Imaging or Ultrasound Elastic Tensor Imaging (ETI) can derive the fiber directions by measuring the anisotropy of water diffusion or tissue elasticity, but these techniques present severe limitations in clinical setting. In this study, we propose a new technique, the Backscatter Tensor Imaging (BTI) which enables determining the fibers directions in skeletal muscles and myocardial tissues, by measuring the spatial coherence of ultrasonic speckle. We compare the results to ultrasound ETI. Acquisitions were performed using a linear transducer array connected to an ultrasonic scanner mounted on a motorized rotation device with angles from 0° to 355° by 5° increments to image ex vivo bovine skeletal muscle and porcine left ventricular myocardial samples. At each angle, multiple plane waves were transmitted and the backscattered echoes recorded. The coherence factor was measured as the ratio of coherent intensity over incoherent intensity of backscattered echoes. In skeletal muscle, maximal/minimal coherence factor was found for the probe parallel/perpendicular to the fibers. In myocardium, the coherence was assessed across the entire myocardial thickness, and the position of maxima and minima varied transmurally due to the complex fibers distribution. In ETI, the shear wave speed variation with the probe angle was found to follow the coherence variation. Spatial coherence can thus reveal the anisotropy of the ultrasonic speckle in skeletal muscle and myocardium. BTI could be used on any type of ultrasonic scanner with rotative phased-array probes or 2-D matrix probes for non-invasive evaluation of myocardial fibers.

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“…Many studies have described phenomena that are related or potentially related to myocardial ultrasonic integrated backscatter and its variation during the cardiac cycle (Barzilai et al 1984;Glueck et al 1985;Hoffmeister et al 1991;Maderas et al 1988;Mottley and Miller 1988;Mottley et al 1984;Recchia et al 1993Recchia et al , 1995Sagar et al 1987Sagar et al , 1988Sagar et al , 1990Wear et al 1986Wear et al , 1989Wickline et al 1985aWickline et al , 1985bWickline et al , 1991Wickline et al , 1992). An important observation has been the empirical inverse linear relation between wall thickness and integrated backscatter (Rijsterborgh et al 1990van der Steen et al 199 1) , This relation does not seem to hold in all cases (Milunski et al 1989a(Milunski et al , 1989b.…”

Section: Discussionmentioning

confidence: 99%

Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium

Steen

Rijsterborgh

Lancée

et al. 1997

Ultrasound in Medicine & Biology

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Abstract-This study was performed to investigate the relationship between the cyclic variation of integrated backscatter and myocardial wall thickening in stunned myocardium. Dllerent definitions of cyclic variation were evaluated to be able to compare with other studies. Ultrasound data were acquired from 10 openchested Yorkshire pigs (25-33 kg) at baseline, during regional ischemia and during 30 min of stun&g, using a broadband ultrasound transducer (3-7 MHz) sutured directly upon the left ventricular myocardlal wall. Cyclic variation of integrated backscatter and myocardlal wall thickening were calculated using three definitions obtained from the literature. Independent of the definition, cyclic variation of wall thickness and integrated backscatter were blunted during acute &hernia and returned transiently to or above baseline during the first minute of reperfusion, followed by a gradual decrease to a level under baseline during stunning. An early return of the cyclic variation of the integrated backscatter was not observed ln pigs, independent of the data processing used. The relationship between integrated backscatter and wall thickness was maintained. 0 1997 World Federation for Ultrasound in Medicine & Biology.

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Three-dimensional characterization of human ventricular myofiber architecture by ultrasonic backscatter.

Abstract: Normal human left ventricular architecture comprises a highly aligned array of cardiac myofibers whose orientation depends on transmural location.

Cited by 59 publications

References 32 publications

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Ultrasound backscatter tensor imaging (BTI): analysis of the spatial coherence of ultrasonic speckle in anisotropic soft tissues

Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium

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