Myocardial T1 Mapping for Detection of Left Ventricular Myocardial Fibrosis in Chronic Aortic Regurgitation: Pilot Study

Abstract

Segment-based myocardial T1 mapping has the potential for showing differences between relaxation times in aortic regurgitation and in normal hearts, suggesting the existence of a diffuse myocardial fibrotic process.

T 1 Mapping With Cardiovascular MRI Is Highly Sensitive for Fabry Disease Independent of Hypertrophy and Sex

“…However, a wide range of values has been reported with other T 1 mapping methods. Wacker et al 43 measured noncontrast T 1 values of 1219 ms with a saturation-recovery approach similar to the SASHA method, whereas the commonly used modified look-locker inversion-recovery family of pulse sequence has reported values ranging from 939 to 1029 ms at 1.5 T. 11,24,38,[44][45][46][47][48] A previous direct comparison of modified look-locker inversion-recovery and SASHA methods in 10 healthy subjects yielded noncontrast T 1 values that match this trend, with modified look-locker inversion-recovery values of 935.5±24.9 ms and SASHA values of 1175.2±27.6 ms. 13 Sado et al 33 recently reported uniformly lower noncontrast T 1 values of 968±27.6 ms in healthy subjects and 858±27.6 ms in FD as compared with our currently reported T 1 values. Importantly, they reported absolute mean differences between FD and healthy controls 110 ms that is similar to our reported mean difference of 107 ms.…”

The Future of Cardiovascular Imaging in the Diagnosis and Management of Heart Failure, Part 1

“…The T1 time is shortened by fibrosis, and T1 mapping is a potentially quantifiable marker of the extent and severity of fibrosis when validated against biopsy samples 26 and applied in clinical settings associated with nonischemic fibrosis. 27 Differences in transverse relaxation times of hydrogen protons (T2*) reveal differences in tissue water content, which may be attributable to fibrosis. 28 …”

The role of imaging and molecular imaging in the early detection of metabolic and cardiovascular dysfunctions

“…61 On the basis of the T1-weighted parametric map, cardiac MRI is also able to detect myocardial fibrosis. [62][63][64][65] Each tissue has a normal range of T1 relaxation times, 66 allowing definition of cutoff values to differentiate normal from abnormal relaxation times, and hence normal from pathological states. The method is sensitive enough not only to differentiate normal from infarcted areas, but also to differentiate acute from chronic MI.…”