The Future of Cardiovascular Imaging in the Diagnosis and Management of Heart Failure, Part 1

Marwick, Thomas H.; Schwaiger, Markus

doi:10.1161/circimaging.108.792408

Cited by 23 publications

(17 citation statements)

References 73 publications

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“…Thus, T1 mapping has been proposed as a means to identify diffuse fibrosis of the myocardium. 9,10 Although several clinical studies have been performed suggesting the validity of this concept, 11,12 experimental data are lacking. Small-animal Look-Locker inversion recovery (SALLI) has been proposed as a tool to generate cardiac T1 maps from small animals at high heart rates.…”

Section: Editorial See P 604 Clinical Perspective On P 640mentioning

confidence: 99%

Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping

Messroghli

Nordmeyer

Dietrich

et al. 2011

Circ: Cardiovascular Imaging

106

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Background-The concentration of gadopentetate dimeglumine in myocardium and blood can be assessed from T1 measurements and can be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping. Methods and Results-Sprague-Dawley rats (nϭ10) were subjected to continuous angiotensin-2 (AT2) infusion for 2 weeks via a subcutaneously implanted minipump system. Magnetic resonance imaging (MRI) was performed both before and after AT2 infusion. The MRI protocol included multislice cine imaging and before-and-after contrast small-animal Look-Locker inversion recovery T1 mapping and late gadolinium enhancement imaging. Myocardial ECV was calculated from hematocrit and T1 values of blood and myocardium. During the course of AT2 infusion, the meanϮSD systolic blood pressure increased from 122Ϯ10.9 to 152Ϯ27.5 mm Hg (Pϭ0.003). Normalized heart weight was significantly higher in AT2-treated animals than in control littermates (Pϭ0.033

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Section: Editorial See P 604 Clinical Perspective On P 640mentioning

confidence: 99%

Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping

Messroghli

Nordmeyer

Dietrich

et al. 2011

Circ: Cardiovascular Imaging

106

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show abstract

“…While spatial resolution is excellent, temporal resolution of the beating heart is more limited. (Marwick and Schwaiger 2008) The procedure is relatively costly, restricting clinical and research use. In addition, the electromagnetic field used in this procedure can interfere with the electronics of the pacing device, and generate heat within the leads, potentially damaging the myocardium.…”

Section: Methods Of Quantifying LV Functionmentioning

confidence: 99%

Right Ventricular Pacing and Mechanical Dyssynchrony

Burns¹,

Gage²,

Bank³

2012

Electrophysiology - From Plants to Heart

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“…Cardiovascular magnetic resonance (CMR) is a rapidly evolving technology that is increasingly being used for the noninvasive imaging of the expanding HF population (4) . Future developments in the care of advanced heart disease, including stem cell therapy, device therapy to control remodeling, and percutaneous valve interventions, as well as the need to identify subclinical heart disease, are likely to expand this use (6) .…”

Section: Commentsmentioning

confidence: 99%

“…CMR methods may be useful in the quantification of fibrosis even in visual negative delayed enhancement imaging. The T1 time is shortened by fibrosis, and T1 mapping is a potentially quantifiable marker of the extent and severity of fibrosis when validated against biopsy samples and applied in clinical settings associated with nonischemic fibrosis (6) .…”

Section: Cmr Imagingmentioning

confidence: 99%

“…The latter requires not only rigorous clinical validation in prospective trials that adhere to evidence-based medicine criteria but also appropriate training of cardiovascular specialists in the cost efficient use of imaging technologies (6,7) . Besides these clinical benefits, new imaging technologies will change cardiovascular research by providing unique tools to quantitatively study the disease process in animal models and humans.…”

Section: Important Considerationsmentioning

confidence: 99%

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