Myocardial structural response following administration of a fatty diet to rats

Fischer, Vernon W.

doi:10.1016/0014-4800(79)90055-8

Cited by 3 publications

(1 citation statement)

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“…A 22% corn oil addition to a rat diet led only to a slightly elevated cholesterol content in heart, and no changes were observed in the liver. Fischer (1979) described various stages of morphological changes in heart muscle of rats fed a high-fat diet, leading ultimately to myocardial infarcts. Lipid depositions in cardiomyocytes were the first step, followed by a stimulation of the reticulo-endothelial system with a subsequent invasion of macrophages in the interstitial spaces.…”

Section: Discussionmentioning

confidence: 99%

Effects of Corn Oil Addition to the Diet on the Energy Metabolism of Heart, Liver and Kidney of Female Rats

Bachmann

Weber

1990

Pharmacology & Toxicology

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Female rats (SIV-50, Sprague Dawley) given a diet enriched with corn oil (10% and 25% addition to rat chow, w/w) for four weeks showed changes in the energy metabolism of heart, liver and kidneys, that is, changes in oxygen consumption and uncoupling of oxidative phosphorylation of heart, liver and kidney mitochondria, concomitant to a decrease in heart mitochondrial creatine kinase activity and an increase in heart mitochondrial creatine content. The high fat diet also affected calcium binding and Na/K-, Mg- and Ca-ATPases of a cardiac myocyte membrane fraction. Lipid feeding also led to increase (biphasic and transient) of phospholipids, triglycerides and free fatty acids in the three organs studied, but in no case to hypertrophy.

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Section: Discussionmentioning

confidence: 99%