Myocardial Strain Assessment in Cystic Fibrosis

Labombarda, Fabien; Pellissier, Arnaud; Ellafi, Madiha; Creveuil, C.; Ribault, Virginie; Laurans, Murielle; Guillot, M; Bergot, Emmanuel; Grollier, Gilles; Milliez, Paul; Zalcman, Gérard; Saloux, Éric

doi:10.1016/j.echo.2011.06.004

Cited by 26 publications

(71 citation statements)

References 29 publications

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“…The peak systolic strain rate (Ssr), early (Esr), and late (Asr) peak diastolic strain rates were measured (Figure 1). With our measurement method, strain and strain rates for the septal wall are reliable parameters for both reproducibility and repeatability, as previously reported by our team [15] . Apnea is required for color TDI acquisition and our study limit was age 5 years.…”

Section: Strain Analysissupporting

confidence: 56%

“…Overall, 30 consecutive children and adolescents with type 1 diabetes (age range [5][6][7][8][9][10][11][12][13][14][15][16][17] years, male: 53%) were recruited at our pediatric endocrinology department and enrolled in this prospective cohort. Among children with diabetes, HBA 1c ranged from 6.8% to 12.7% , 63% of the patients with diabetes patients had HBA 1C > 8 % and mean diabetes duration was 5.1 ± 3.1 years.…”

Section: Populationmentioning

confidence: 99%

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Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Hodžić

Ribault

Maragnès

et al. 2016

Journal of Translational Internal Medicine

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Background and Objectives: Type 1 diabetes is a major cardiovascular risk factor associated with an excess of mortality in young adults due to premature cardiovascular events, which includes heart failure. The relation between type 1 diabetes and cardiac structure and function in children was poorly documented. Our study investigates (1) whether type 1 diabetic children have echocardiographic signs of subclinical cardiac dysfunction assessed by tissue Doppler strain and (2) whether state of metabolic control and diabetes duration have any influence on the cardiac event. Methods: Standard echocardiography and tissue Doppler imaging were prospectively performed in type 1 diabetic children. Left ventricular dimensions, standard indices of systolic and diastolic function, and septal longitudinal strain were investigated. Results: Thirty consecutive asymptomatic diabetic children (age: 12.4 [5-17] years; males: 53%) were compared to 30 age and sex-matched healthy control subjects. Left ventricular mass index and diastolic septal thickness were significantly increased in diabetic children. There was no difference between two groups as regards the left ventricular ejection fraction and conventional mitral Doppler parameters (E, A, Ea). The global longitudinal systolic strain and strain rate were found to be decreased in children with diabetes. The global longitudinal early diastolic strain rate (Esr) was negatively correlated with metabolic control. Longitudinal strain was not correlated with diabetes duration. Conclusion: Children with Type 1 diabetes had subclinical alterations in left ventricular size and longitudinal myocardial deformation.

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Section: Strain Analysissupporting

confidence: 56%

Section: Populationmentioning

confidence: 99%

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Hodžić

Ribault

Maragnès

et al. 2016

Journal of Translational Internal Medicine

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“…Although cystic fibrosis is associated with cardiac impairment, 30,31 it is not clinically associated with hypertension, a systemic effect that would be predicted as a consequence of S1P-dependent augmentation of myogenic tone and hence peripheral resistance. However, mean arterial pressure measurements integrate several factors and mechanisms (eg, blood volume, cardiac output, total peripheral resistance).…”

Section: Discussionmentioning

confidence: 99%

“…However, mean arterial pressure measurements integrate several factors and mechanisms (eg, blood volume, cardiac output, total peripheral resistance). In addition to cardiac dysfunction, 30,31 patients with cystic fibrosis are known to have increased sweat salt loss 32 ; both are confounding factors that could ameliorate the effects of increased resistance artery tone. Nevertheless, our findings align well with previous studies reporting altered lipid metabolism in patients with cystic fibrosis (eg, accumulation of ceramide, 33 a lipid mediator involved in the sphingolipid rheostat 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Briefly, confluent VSMC monolayers were lysed (6 freeze-thaw cycles using liquid nitrogen followed by room temperature vortexing) in buffer containing 10mM Tris (pH 7.3), 140mM NaCl, 1% Triton-X-100, 5mM EDTA, 1mM DTT and 25μg/ml protease inhibitor cocktail. The samples were centrifuged (30 A standard polyacrylamide gel electrophoresis procedure was utilized to separate the protein samples. Briefly, protein levels were quantified spectrophotometrically using Bradford reagent.…”

Section: Western Blottingmentioning

confidence: 99%

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Tumor Necrosis Factor-α–Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure

Meißner¹,

Yang²,

Kroetsch³

et al. 2012

Circulation

150

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Background-Sphingosine-1-phosphate (S1P) signaling is a central regulator of resistance artery tone. Therefore, S1P levels need to be tightly controlled through the delicate interplay of its generating enzyme sphingosine kinase 1 and its functional antagonist S1P phosphohydrolase-1. The intracellular localization of S1P phosphohydrolase-1 necessitates the import of extracellular S1P into the intracellular compartment before its degradation. The present investigation proposes that the cystic fibrosis transmembrane conductance regulator transports extracellular S1P and hence modulates microvascular S1P signaling in health and disease. Methods and Results-In cultured murine vascular smooth muscle cells in vitro and isolated murine mesenteric and posterior cerebral resistance arteries ex vivo, the cystic fibrosis transmembrane conductance regulator (1) is critical for S1P uptake; (2) modulates S1P-dependent responses; and (3) is downregulated in vitro and in vivo by tumor necrosis factor-␣, with significant functional consequences for S1P signaling and vascular tone. In heart failure, tumor necrosis factor-␣ downregulates the cystic fibrosis transmembrane conductance regulator across several organs, including the heart, lung, and brain, suggesting that it is a fundamental mechanism with implications for systemic S1P effects. Conclusions-We identify the cystic fibrosis transmembrane conductance regulator as a critical regulatory site for S1P signaling; its tumor necrosis factor-␣-dependent downregulation in heart failure underlies an enhancement in microvascular tone. This molecular mechanism potentially represents a novel and highly strategic therapeutic target for cardiovascular conditions involving inflammation. (Circulation. 2012;125:2739-2750.)Key Words: acute myocardial infarction Ⅲ hemodynamics Ⅲ myogenic vasoconstriction Ⅲ signal transduction Ⅲ vasomotor tone S phingosine-1-phosphate (S1P) is a ubiquitous signaling mediator that directs a diverse array of biological processes. 1 In the microcirculation, S1P is a potent vasoconstrictor and a central mediator regulating myogenic tone. [2][3][4][5] This confers S1P signaling with significant importance in the control of blood flow autoregulation, tissue perfusion, and systemic blood pressure. Editorial see p 2692 Clinical Perspective on p 2750The potent and pleiotropic effects of S1P are confined both spatially and temporally 6 ; however, the molecular mechanisms limiting S1P bioavailability are not completely understood. We have demonstrated that S1P phosphohydrolase-1 (SPP1), an intracellular enzyme primarily localized to the endoplasmic reticulum, 7,8 degrades extracellular S1P. 3 As a consequence, we concluded that an S1P "import" mechanism must be present in vascular smooth muscle cells. Boujaoude et al 9 have provided indirect evidence that the cystic fibrosis transmembrane conductance regulator (CFTR) could act as this S1P transporter and thereby limit S1P receptor-mediated effects. Accordingly, we have observed that CFTR inhibition specifically enhance...

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Decreased Right Ventricular Function in Healthy Pediatric Cystic Fibrosis Patients Versus Non-Cystic Fibrosis Patients

et al. 2012

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Right ventricular (RV) dysfunction may occur in patients with cystic fibrosis (CF). Tissue Doppler imaging (TDI) and strain and strain rate analysis are new echocardiographic tools that can quantitate RV function. This study aimed to compare the RV function between healthy CF patients and non-CF patients to determine whether differences exist. Healthy CF children and age-matched non-CF children were enrolled in the study. In this study, TDI analysis of the RV free wall was performed at the level of the tricuspid valve annulus. Two-dimensional speckle echocardiography was used to measure global strain and strain rates in a six-segment model of the RV. Independent t tests were used to compare the groups. The study enrolled 18 CF patients (age, 7.7 ± 2.0 years) and 15 non-CF patients (age, 6.4 ± 2.5 years). The age difference was not significant. The forced expiratory volume in the first second (FEV(1)) for the CF patients was 91 ± 15 %. The systolic annular velocity by TDI was significantly lower in the CF group. The RV strain values in the CF group were significantly lower in four of the six segments (RV free-wall base, RV free-wall mid, RV septal apex, and RV septal mid). The global strain value, the systolic strain rate, and the early diastolic strain rate were significantly lower in the CF group. Decreased systolic and diastolic RV properties were present in young healthy CF patients. Further studies with longitudinal follow-up evaluation are needed to determine the significance of these findings for the pediatric CF population.

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Myocardial Strain Assessment in Cystic Fibrosis

Cited by 26 publications

References 29 publications

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Tumor Necrosis Factor-α–Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure

Decreased Right Ventricular Function in Healthy Pediatric Cystic Fibrosis Patients Versus Non-Cystic Fibrosis Patients

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