Myocardial protection during elective coronary artery bypasses grafting by pretreatment with omega-3 polyunsaturated fatty acids

Veljović, Milić; Popadić, Ana; Vukic, Zoran; Ilić, Radoje; Trifunović, Zoran; Antunović, Marko; Mandarić, Vladimir; Tišma, Svetislav; Marković, Zoran

doi:10.2298/vsp1305484v

Cited by 16 publications

(16 citation statements)

References 46 publications

(32 reference statements)

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“…In any case, the results of our study show that the postoperative inhibition of platelet aggregation by PUFAs, particularly pronounced in the COL test, did not affect the intra-and postoperative hematological parameters, with the risk of bleeding, as the most dangerous, being equal to the placebo group. This finding undoubtedly speaks in favour of omega-3 PUFAs use as cardioprotectors in patients with open heart surgery, found in our recent study 12 .…”

Section: The Influence Of Omega-3 Pufas In Cpb Procedures On the Activsupporting

confidence: 55%

Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUFAs) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass grafting

et al. 2013

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This prospective, randomized, placebo-controlled, single-center trial was performed on parallel groups. The patients (n = 40) undergoing elective CABG were randomized receivin preoperative intravenous omega-3 PUFAs (Omegaven 10%) infusion (the PUFAs group) or the same volume of 0.9% saline solution infusion (the control group). Infusion was given a day before surgery and repeated four hours before starting extracorporeal circulation (CPB) via the pe ripheral vein at single doses of 100 mL (25 mL/h). Platelet function analysis was performed using multiple electrode aggregometry (MEA, multiplate-analyzer) before starting CPB and 2 h postoperatively for the patients of both groups. Results. There were no clinically relevant differ ences in baseline characteristics between the groups. He matological parameters were not significantly different between the groups pre-, intra- and postoperatively. Dur ing the first 24 h after surgery, the loss of blood was simi lar in the PUFAs and the control group (680 +/- 274 mL and 608 +/- 210 mL, respectively; p = 0.356). Postopera tively, platelet aggregation was not significantly different between the PUFAs and the control group in adenosine diphosphate (ADP) test (39 +/- 11 and 42 +/- 15, respec tively; p = 0.701), arachidonic acid (ASPI) test (64 +/- 24 and 70 +/- 27, respectively; p = 0.525) and trombin receptor-activating peptide (TRAP) test (68 +/- 25 and 75 + 26, respectively; p = 0.396), while their aggregation in collagen (COL) test was statistically significantly lower in the PUFAs related to the control group (32 +/- 15 and 47 +/- 20, re spectively; p = 0.009). Conclusion. Acute pretreatment with omega-3 PUFAs insignificantly affected the activity of platelets and did not influence postoperative blood loss.

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Section: The Influence Of Omega-3 Pufas In Cpb Procedures On the Activsupporting

confidence: 55%

Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUFAs) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass grafting

et al. 2013

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“…In one of them, 40 patients subject to elective coronary artery bypass grafting were randomized to receive a preoperative IVLE of FO 100% at doses of 10 g (about 0.11 g/kg) or saline. The results of this study showed that the extraction of oxygen and the uptake of lactate were markedly increased in the FO pretreated patients compared to the control group (37). In the second study, 23 patients were randomized to receive FO 100% 0.2 g/kg or saline administered two times on the evening before cardiopulmonary bypass and immediately before surgery.…”

Section: Respiratory Gas Interchangementioning

confidence: 94%

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Joaquín¹,

Florit-Sureda²

2017

Nutr Hosp

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Mateu-de-Antonio J, Florit-Sureda M. Effects unrelated to anti-infl ammation of lipid emulsions containing fi sh oil in parenteral nutrition for adult patients. Nutr Hosp 2017;34:193-203 ResumenSe han publicado varias revisiones y metaanálisis sobre la modulación de las respuestas infl amatorias e inmunológicas por la administración de ácidos grasos poliinsaturados (AGPI) omega-3. Sin embargo, los AGPI omega-3 ejercen otras acciones no directamente relacionadas con estas respuestas. El objetivo de este trabajo es revisar los efectos de las emulsiones lipídicas intravenosas (ELIV) que contienen aceite de pescado (AP) en la nutrición parenteral (NP) de pacientes adultos. Estas emulsiones pueden tener un papel importante en la prevención de las alteraciones del perfi l hepático o de la enfermedad hepática asociada a la NP (EHANP) en comparación con las ELIV sin AP. Los estudios que usaron dosis ≥ 0,150 mg/kg/día presentaron resultados más positivos que aquellos con dosis menores. Una vez se ha presentado la EHANP, el uso de una ELIV compuesta exclusivamente de AP, a dosis de 0,25-1 g de AP/kg/día durante varias semanas, podría atenuar o incluso revertir la alteración hepática y la colestasis cuando la administración de la NP es crónica. Las ELIV con AP parecen tener un aclaramiento plasmático más rápido, lo que podría suponer una ventaja en ciertos pacientes. Algunos estudios también sugieren que estas emulsiones podrían mejorar la función respiratoria. En general, estas ELIV que contienen AP son muy seguras, no aumentan el estrés oxidativo e incluso incrementan el nivel de alfa-tocoferol plasmático. Asimismo, no alteran la sensibilidad a la insulina o el control glicémico y tampoco se ha demostrado que afecten clínicamente a la agregación plaquetaria o a la hemostasia. En conclusión, el uso de ELIV con AP en la NP podría suponer algunas ventajas frente a la ELIV sin AP, además de la modulación de la respuesta infl amatoria sistémica. AbstractSeveral reviews and meta-analyses on modulated infl ammatory and immunologic responses after the administration of omega-3 polyunsaturated fatty acids (PUFAs) in different diseases and conditions have been published. However, omega-3 PUFAs exert several other actions which are not directly related to immunologic or infl ammatory responses. The aim of this paper was to review the effects which are not directly related to immunologic and infl ammatory responses of intravenous lipid emulsions (IVLEs) containing fi sh oil (FO) in parenteral nutrition (PN) for adult patients. IVLEs containing FO could have a role in the prevention of alterations in liver enzyme tests (LETs) or PN-associated liver disease (PNALD). Studies using FO doses of ≥ 0.150 mg/kg/day or IVLEs with high FO concentration reported more positive results than those with lower doses. Once PNALD was developed, the use of IVLEs exclusively composed of FO at doses of 0.25-1 g of FO/kg/day for several weeks could attenuate or even eradicate cholestasis and liver alteration. IVLEs containing FO seemed to have faster...

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“…Thus, protection of the non‐perfused heart during cardio‐pulmonary bypass is of special interest. A number of strategies exist to minimize ischemic damage to the heart: cardioplegia with histidine‐tryptophan‐ketoglutarate solution, hypothermia, polyunsaturated fatty acids or remote preconditioning . Recent data show cerebral protective effects during cardio‐pulmonary bypass attributed to the antibiotic agent minocycline.…”

Section: Introductionmentioning

confidence: 99%

“…A number of strategies exist to minimize ischemic damage to the heart: cardioplegia with histidine-tryptophan-ketoglutarate solution, hypothermia, polyunsaturated fatty acids or remote preconditioning. 16,17 Recent data show cerebral protective effects during cardio-pulmonary bypass attributed to the antibiotic agent minocycline. Drabek and coworkers found in 2014 that minocycline attenuates tumour necrosis factor (TNF)-a levels in the brain after hypothermic circulatory arrest and suggested that it might be a beneficial therapeutic supplement during circulatory arrest.…”

Section: Introductionmentioning

confidence: 99%

Effects of minocycline on parameters of cardiovascular recovery after cardioplegic arrest in a rabbit Langendorff heart model

Salameh

Halling

Seidel

et al. 2015

Clin Exp Pharma Physio

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Pharmacological cardiac organ protection during cardiopulmonary bypass presents an opportunity for improvement. A number of different strategies have been established to minimize ischemia/reperfusion-induced damage to the heart. Among these, cardioplegia with histidine-tryptophan-ketoglutarate solution and hypothermia are the most frequently used regimens. The antibiotic minocycline has been used in this context for neuroprotection. The aim of the current study was to evaluate whether the application of minocycline prior to cardioplegia exerts a protective effect on cardiac muscle. For this purpose, this study investigated six rabbit hearts with minocycline treatment (1 μmol/L) and six without in a Langendorff model of 90 min cold cardioplegic arrest using Custodiol followed by a 30 min recovery phase. Histological analysis of cardiac muscle revealed that markers of apoptosis, oxidative and nitrosative stress were significantly lower in the minocycline group, whereas adenosine triphosphate (ATP)- and malondialdehyde (MDA)-levels and O2-consumption were not affected by minocycline. Functionally, recovery of dP/dt (max) and dP/dt (min) was significantly faster in the minocycline group than in control. This leads to the conclusion that adding minocycline to the cardioplegic solution may improve left ventricular recovery after cardioplegic arrest involving reduced pro-apoptotic effects.

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Myocardial protection during elective coronary artery bypasses grafting by pretreatment with omega-3 polyunsaturated fatty acids

Cited by 16 publications

References 46 publications

Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUFAs) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass grafting

Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUFAs) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass grafting

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Effects of minocycline on parameters of cardiovascular recovery after cardioplegic arrest in a rabbit Langendorff heart model

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