Effects unrelated to anti-inflammation of lipid emulsions containing fish oil  in parenteral nutrition for adult patients

Joaquín, Antonio; Florit-Sureda, Marta

doi:10.20960/nh.882

Cited by 7 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The detailed differences of the pathomechanisms that underlie liver damage in both PN-dependent paediatric and adult patients are beyond the scope of this paper. More information is available in some excellent recent reviews [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota

2017

View full text Add to dashboard Cite

Parenteral nutrition (PN) provides life-saving nutritional support in situations where caloric supply via the enteral route cannot cover the necessary needs of the organism. However, it does have serious adverse effects, including parenteral nutrition-associated liver disease (PNALD). The development of liver injury associated with PN is multifactorial, including non-specific intestine inflammation, compromised intestinal permeability, and barrier function associated with increased bacterial translocation, primary and secondary cholangitis, cholelithiasis, short bowel syndrome, disturbance of hepatobiliary circulation, lack of enteral nutrition, shortage of some nutrients (proteins, essential fatty acids, choline, glycine, taurine, carnitine, etc.), and toxicity of components within the nutrition mixture itself (glucose, phytosterols, manganese, aluminium, etc.). Recently, an increasing number of studies have provided evidence that some of these factors are directly or indirectly associated with microbial dysbiosis in the intestine. In this review, we focus on PN-induced changes in the taxonomic and functional composition of the microbiome. We also discuss immune cell and microbial crosstalk during parenteral nutrition, and the implications for the onset and progression of PNALD. Finally, we provide an overview of recent advances in the therapeutic utilisation of pro- and prebiotics for the mitigation of PN-associated liver complications.

show abstract

Section: Introductionmentioning

confidence: 99%

Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota

2017

View full text Add to dashboard Cite

show abstract

“… 24 – 27 Numerous adult studies have shown that fish oil containing lipid emulsion has a positive effect on liver enzyme tests and prevention of PN-associated liver disease in surgical or critically ill patients. 28 – 30 Three studies showed a 15% to 25% faster plasma lipid clearance or 25% to 45% shorter half-life of experimental fish oil containing lipid emulsion, even with different fish oil content. 31 – 33 Liang et al.…”

Section: Discussionmentioning

confidence: 99%

Parenteral nutrition with fish oil-based lipid emulsion reduces the risk of cholestasis in preterm infants

et al. 2021

View full text Add to dashboard Cite

Objective Preterm infants receive long-term parenteral nutrition (PN) for gastrointestinal immaturity. This study aimed to determine if mixed lipid emulsions containing fish oil decrease the incidence of PN-associated cholestasis by reducing oxidative stress and providing an anti-inflammatory effect. Methods This retrospective cohort study enrolled 399 very low birth weight premature infants (gestational age ≤32 weeks) between January 2009 and November 2017 at a single neonatal intensive care unit. Preterm infants received total PN with either mixed lipid emulsion including fish oil (SMOFlipid®, n = 195) or soybean oil-based lipid emulsion (Lipovenoes®, n = 204) for at least 7 days. We compared the outcomes of PN-associated cholestasis, comorbidities, and mortality between the groups. Results The incidence of PN-associated cholestasis was significantly lower in the SMOFlipid group than in the Lipovenoes group. The duration to full feeding days was significantly shorter in the SMOFlipid group compared with the Lipovenoes group. Relevant complications, such as severe retinopathy of prematurity and bronchopulmonary dysplasia, were also significantly reduced in the SMOFlipid group compared with the Lipovenoes group. Conclusion In premature infants, PN with fish oil-based lipid emulsions is associated with a lower incidence of PN-associated cholestasis compared with soybean oil-based lipid emulsions.

show abstract

“…In the current literature the etiology of PN-associated cholestasis is multifactorial, with causes including prematurity, lack of enteral nutrition, sepsis, and factors relevant to the duration and composition of the PN [15][16][17][18]. Numerous adult studies have revealed that fish oil containing lipid emulsion has a positive effect on liver enzyme tests and prevention of PN-associated liver disease in surgical or critically ill patients [19][20][21]. Three studies resulted in a 15-25% faster plasma lipid clearance or 25-45% shorter half-life of the experimental fish oil containing lipid emulsion, even with different fish oil content [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Parenteral nutrition with fish oil-based lipid emulsion reduces the risk of cholestasis in preterm infants

WANG

Chen

Tsao

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Preterm infants received long-term parenteral nutrition (PN) due to gastrointestinal immaturity. Mixed lipid emulsions composed of soybean oil, medium chain triglycerides (MCTs), olive oil, and fish oil, which have a relatively low ω-6: ω-3 ratio, may decrease the incidence of PN-associated cholestasis by reducing oxidative stress and providing an anti-inflammatory effect.Methods The retrospective cohort study enrolled a total 399 very low birth weight (VLBW) premature infants between January 2009 and November 2017 at a single neonatal intensive care unit. Preterm infants received total parenteral nutrition with either mixed lipid emulsion (SMOFlipid, n = 195) or soybean oil-based lipid emulsion (Lipovenoes, n = 204) for at least seven days. We compared the outcomes of PN-associated cholestasis, co-morbidities and mortality.Results The incidence of PN-associated cholestasis was significantly lower in the SMOFlipid group than the Lipovenoes group (10.3% vs 20.1%, P = 0.006). The related clinical laboratory findings, including levels of γ- GT (P = 0.019), triglyceride (P < 0.001), and cholesterol (P = 0.023), were significantly lower in the SMOFlipid group. The duration to full feeding days shortened in the SMOFlipid group compared with the Lipovenoes group (25 ± 10.33 vs 33 ± 16.22, P < 0.001). Relevant complications, such as severe retinopathy of prematurity (ROP, 3.6% vs 14.3%, P < 0.001) and bronchopulmonary dysplasia (BPD, 36.9% vs 46.7%, P = 0.046) were also reduced in the SMOFlipid group versus the Lipovenoes group, but there was no significant effect on severe intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), or mortality in both groups.Conclusions In very premature infants, PN with fish oil-based lipid emulsions is associated with a lower incidence of PN-associated cholestasis compared with soybean oil-based lipid emulsions.

show abstract

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Cited by 7 publications

References 43 publications

Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota

Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota

Parenteral nutrition with fish oil-based lipid emulsion reduces the risk of cholestasis in preterm infants

Parenteral nutrition with fish oil-based lipid emulsion reduces the risk of cholestasis in preterm infants

Contact Info

Product

Resources

About