Myocardial perfusion quantification using the<i>T</i><sub>1</sub>-based FAIR-ASL method: The influence of heart anatomy, cardiopulmonary blood flow and look-locker readout

Kampf, Thomas; Helluy, Xavier; Gutjahr, Fabian Tobias; Winter, Patrick; Meyer, Cord; Jakob, Peter M.; Bauer, Wolfgang R.; Ziener, Christian H.

doi:10.1002/mrm.24843

Cited by 13 publications

(12 citation statements)

References 67 publications

(137 reference statements)

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“…For the in vivo study, the

T_{1}^{GS}

and

T_{1}^{SS}

values used were the observed

T_{1}^{*}

s. As has been discussed previously , where the Deichmann‐Haase correction is used the ratio of the relaxation times remains constant

T_{1}^{GS} {/ T}_{1}^{SS} = T_{1}^{* GS} / T_{1}^{* SS}

as the fitted values of A and B should remain the same for both the GS and SS cases. Thus, use of the correction would have no effect on the final value of MBF.…”

Section: Methodsmentioning

confidence: 97%

“…where l ¼ 0.92 mL/g (25) is the blood-tissue partition coefficient of water, T blood 1 is the relaxation time of the blood pool and T GS 1 and T SS 1 are the values for the longitudinal relaxation time calculated for the myocardium, from the GS and SS experiment, respectively. For the in vivo study, the T GS 1 and T SS 1 values used were the observed T Ã 1 s. As has been discussed previously (26,27), where the Deichmann-Haase correction is used the ratio of the relaxation times remains constant…”

Section: Image Analysismentioning

confidence: 99%

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A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

et al. 2016

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PurposeA novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath‐hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability.MethodsA flow‐sensitive alternating inversion recovery (FAIR) ASL method with Look‐Locker readout (LL‐FAIR‐ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices. The method was investigated for reproducibility by Bland‐Altman analysis and statistical measures, the coefficients of reproducibility (CR) and variation (CV) are reported.ResultsThe MBF values for the basal, mid, and apical slices were 1.04 ± 0.40, 1.06 ± 0.46, and 1.06 ± 0.38 ml/g/min, respectively (mean ± SD), which compare well with literature values. The CV across all scans, 43%, was greater than the between‐session and within‐session values, at 16 and 13%, respectively, for the mid‐ventricular slice. The change in MBF required for detection, from the CR, was 61% between‐session and 53% within‐session for the mid‐ventricle.ConclusionThis study shows the feasibility of the LL‐FAIR‐ASL method for the quantification of MBF. The statistical measures reported will allow the planning of future clinical research studies involving rest and stress measurements. Magn Reson Med 78:541–549, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…For the in vivo study, the

T_{1}^{GS}

and

T_{1}^{SS}

values used were the observed

T_{1}^{*}

s. As has been discussed previously , where the Deichmann‐Haase correction is used the ratio of the relaxation times remains constant

T_{1}^{GS} {/ T}_{1}^{SS} = T_{1}^{* GS} / T_{1}^{* SS}

as the fitted values of A and B should remain the same for both the GS and SS cases. Thus, use of the correction would have no effect on the final value of MBF.…”

Section: Methodsmentioning

confidence: 97%

Section: Image Analysismentioning

confidence: 99%

A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

et al. 2016

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“…At HF, the ASL sequence benefits from a better difference between T1 ns and T1 SS , this increases with the magnetic field strength for a given level of perfusion [159]. Over time, the ASL sequence has been properly applied to measure MBF in different mouse models of cardiovascular diseases, after some methodological adjustments to improve the resolution and scan time [2,32,55,80,135,144,162], with a proven reproducibility [32].…”

Section: Perfusionmentioning

confidence: 99%

High field magnetic resonance imaging of rodents in cardiovascular research

et al. 2016

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Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.

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“…This is in analogy to the "mean relaxation time approximation" in nuclear spin dephasing [38,62]. While considering the two high-frequency moments µ 0 and µ 1 , the corresponding (2,0)-GMA with f (2,0) = µ 0 and Ŵ (2,0) = µ 1 /µ 0 = 1/τ 0 describes the short time behavior of K(t) whereas the (0, 2)-GMA with the two low-frequency moments µ −2 and µ −1 and parameters f (0,2) = µ 2 −1 /µ −2 and Ŵ (0,2) = µ −1 /µ −2 = 1/τ −2 is a measure for the long time behavior.…”

Section: Appendices Appendix Amentioning

confidence: 95%

Generalized Moment Analysis of Magnetic Field Correlations for Accumulations of Spherical and Cylindrical Magnetic Perturbers

et al. 2016

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In biological tissue, an accumulation of similarly shaped objects with a susceptibility difference to the surrounding tissue generates a local distortion of the external magnetic field in magnetic resonance imaging. It induces stochastic field fluctuations that characteristically influence proton spin dephasing in the vicinity of these magnetic perturbers. The magnetic field correlation that is associated with such local magnetic field inhomogeneities can be expressed in the form of a dynamic frequency autocorrelation function that is related to the time evolution of the measured magnetization. Here, an eigenfunction expansion for two simple magnetic perturber shapes, that of spheres and cylinders, is considered for restricted spin diffusion in a simple model geometry. Then, the concept of generalized moment analysis, an approximation technique that is applied in the study of (non-)reactive processes that involve Brownian motion, allows deriving analytical expressions of the correlation function for different exponential decay forms. Results for the biexponential decay for both spherical and cylindrical magnetized objects are derived and compared with the frequently used (less accurate) monoexponential decay forms. They are in asymptotic agreement with the numerically exact value of the correlation function for long and short times.

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Myocardial perfusion quantification using theT₁-based FAIR-ASL method: The influence of heart anatomy, cardiopulmonary blood flow and look-locker readout

Abstract: It is shown that the Look-Locker readout as well as the nonideal slice-selective inversion experiment have a considerable influence and have to be included properly to correctly quantify myocardial perfusion.

Cited by 13 publications

References 67 publications

A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

High field magnetic resonance imaging of rodents in cardiovascular research

Generalized Moment Analysis of Magnetic Field Correlations for Accumulations of Spherical and Cylindrical Magnetic Perturbers

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Myocardial perfusion quantification using theT1-based FAIR-ASL method: The influence of heart anatomy, cardiopulmonary blood flow and look-locker readout

Abstract: It is shown that the Look-Locker readout as well as the nonideal slice-selective inversion experiment have a considerable influence and have to be included properly to correctly quantify myocardial perfusion.

Cited by 13 publications

References 67 publications

A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

High field magnetic resonance imaging of rodents in cardiovascular research

Generalized Moment Analysis of Magnetic Field Correlations for Accumulations of Spherical and Cylindrical Magnetic Perturbers

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Product

Resources

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Myocardial perfusion quantification using theT₁-based FAIR-ASL method: The influence of heart anatomy, cardiopulmonary blood flow and look-locker readout