2007
DOI: 10.1152/ajpregu.00771.2006
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Myocardial perfusion during exercise in endurance-trained and untrained humans

Abstract: Because of technical challenges very little is known about absolute myocardial perfusion in humans in vivo during physical exercise. In the present study we applied positron emission tomography (PET) in order to 1) investigate the effects of dynamic bicycle exercise on myocardial perfusion and 2) clarify the possible effects of endurance training on myocardial perfusion during exercise. Myocardial perfusion was measured in endurance-trained and healthy untrained subjects at rest and during absolutely the same … Show more

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Cited by 34 publications
(18 citation statements)
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“…During exercise, the threefold increase in MBF in our study reflects the upward shift of the autoregulation plateau induced by metabolic and flow-mediated vasodilatory factors (14). The present exercise data are in accordance to previous studies (6,14,24,27). The blood flow increase was not only achieved by accelerating erythrocyte passage through the capillary network (increased ␤) but also by increasing myocardial blood volume.…”
Section: Discussionsupporting
confidence: 91%
“…During exercise, the threefold increase in MBF in our study reflects the upward shift of the autoregulation plateau induced by metabolic and flow-mediated vasodilatory factors (14). The present exercise data are in accordance to previous studies (6,14,24,27). The blood flow increase was not only achieved by accelerating erythrocyte passage through the capillary network (increased ␤) but also by increasing myocardial blood volume.…”
Section: Discussionsupporting
confidence: 91%
“…In this context, blood flow to cardiac muscle in the left ventricle can equal ϳ500 ml·min Ϫ1 ·100 g Ϫ1 in equines during heavy exercise (12,296,298,351) with values of 300 -400 ml·min Ϫ1 ·100 g Ϫ1 seen in other species including humans (150,204,264,519). Estimates of skin blood flow equal to 6 -8 l/min distributed in perhaps 2 kg of skin in heated humans would also seem to rival the per 100 g values seen in skeletal and cardiac muscle (389).…”
Section: F Is There a Maximum Value For Skeletalmentioning
confidence: 99%
“…77 Finally, in young, healthy humans performing supine bicycle exercise while in the PET scanner ( ) individuals although as expected trained subjects had lower resting HR (44±6 bpm) versus untrained subject (58±6 bpm) but similar MAP (78±6 versus 76±4 mm Hg, respectively). 78 In summary, therefore, across a range of experimental designs and species, including humans (Tables 1-4), exercise levels to ≈10 to 13 METs have been associated with measured MBF of 2 to 4 mL·min…”
Section: Coronary Physiology and Absolute Measurements Of Mbfmentioning
confidence: 91%
“…Factors that may play a role include physical fitness 78 and genetic and other factors (eg, myocyte oxidative stress) that may affect the efficiency of myocardial oxygen utilization both in mitochondrial production of ATP 80 and in generation of external mechanical work. 81 Individual variation notwithstanding, stress MBF levels <1.9 mL·min −1 ·g −1 in a given coronary territory are likely to render it vulnerable to effort-induced ischemia, perhaps not life-threatening or severe but ischemia nonetheless (and potentially life-threatening if engendering ventricular tachycardia/ventricular fibrillation), particularly as effort exceeds 9 METs.…”
Section: ·Gmentioning
confidence: 99%
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