Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

Byrne, Christina; Jensen, Tonny; Hjortkjær, Henrik Øder; Mogensen, Ulrik M.; Kühl, Jørgen Tobias; Fuchs, Andreas; Hilsted, J.; Nordestgaard, Børge G.; Køber, Lars; Kofoed, Klaus F.

doi:10.1016/j.diabres.2014.10.011

Cited by 6 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, it would be interesting to test this diet over a longer period to evaluate whether myocardial perfusion decreases below normal values at later stages in this model as well. Another study in type 1 diabetic patients reported higher myocardial perfusion at rest than in healthy controls [41]. Finally, it is well known that myocardial perfusion can be modified by isoflurane concentration, temperature or heart rate, and that perfusion values likely reflect partial vasodilation [42].…”

Section: Discussionmentioning

confidence: 95%

Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up

Fourny

Lan

Kober

et al. 2019

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

show abstract

Section: Discussionmentioning

confidence: 95%

Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up

Fourny

Lan

Kober

et al. 2019

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

show abstract

“…Previous CTCA studies on asymptomatic CAD in diabetes, either relate mostly to persons with type 2 diabetes mellitus (T2D), do not focus on long-term T1D, or lack a control group. 13,14 The pathophysiology, age of diagnosis, lipid profile and the features of coronary atherosclerosis differ between T1D and T2D. 7,15,16 Therefore, it is essential to study CAD in persons with T1D rather than extrapolating data from studies on T2D, to guide clinical decision making.…”

Section: Introductionmentioning

confidence: 99%

Undiagnosed coronary artery disease in long-term type 1 diabetes. The Dialong study

Holte

Svanteson

Hanssen

et al. 2019

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

Aims: We studied the total prevalence of obstructive coronary artery disease (CAD), undiagnosed CAD and absent CAD in persons with ≥45-year duration of type 1 diabetes (T1D) versus controls, and associations with mean HbA 1c , LDL-cholesterol and blood pressure over 2-3 decades. Methods: We included 76% (n=103) of all persons with T1D diagnosed ≤1970 attending a diabetes center and 63 controls without diabetes. We collected 20-30 years of HbA 1c , LDLcholesterol and blood pressure measurements. Participants without previously diagnosed coronary heart disease (CHD) underwent Computed Tomography Coronary Angiography (CTCA). Undiagnosed obstructive CAD was defined as any coronary stenosis >50% on CTCA, absent CAD as no detected plaque, and total obstructive CAD as either obstructive CAD on CTCA or previous CHD diagnosis. Results: The prevalence of undiagnosed, absent and obstructive CAD was 24% (21/88), 16% (14/88) and 35% (36/103) in T1D versus 10% (6/60), 50% (30/60) and 14% (9/63) in controls (all p<0.05). Mean HbA 1c was associated with undiagnosed obstructive CAD (OR 2.30 95% C.I. 1.13-4.69), while mean LDL-cholesterol was inversely associated with absent CAD (0.12, 0.04-0.43). Conclusions: The prevalence of undiagnosed obstructive CAD was high (24%) in this cohort of long-term survivors with T1D. Mean LDL-cholesterol and HbA 1c were associated with CAD.

show abstract

“…The frequency of MODY varies between 0.83-5.5% in different studies ( 4 , 6 , 7 , 20 , 21 , 22 , 23 ). GCK mutation (up to 95%) was the most common cause in the studies that reported higher MODY frequency ( 6 , 7 , 22 ). Similarly, we detected GCK mutation in 53.8% of the clinically MODY patients who were genetically tested.…”

Section: Discussionmentioning

confidence: 98%

“…Childhood T2D can be confused with maturity onset diabetes of the young (MODY) due to the presence of a family history, presenting features and a possible confounding factor of obesity/overweight ( 5 , 6 ). Furthermore, MODY, especially due to HNF1A mutations can be misclassified as T1D ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

The Distribution of Different Types of Diabetes in Childhood: A Single Center Experience

Haliloğlu

Abali

Buğrul

et al. 2018

Jcrpe

View full text Add to dashboard Cite

Objective:Type 1 diabetes (T1D) is the most common cause of diabetes in childhood but type 2 diabetes (T2D) and maturity onset diabetes of the young (MODY) are emerging as noteworthy causes of diabetes at young ages. The aim is to determine the distribution, trends and clinical features of the different types of diabetes in childhood in one tertiary center.Methods:The records of children and adolescents aged 0-18 years who were diagnosed as “diabetes/persistent hyperglycemia” between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at diagnosis and type of diabetes were recorded.Results:Children and adolescents aged 0-18 years who were diagnosed "diabetes/persistent hyperglycemia" between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at the diagnosis and type of diabetes were recorded.The mean ± standard deviation age of 835 patients (48.7% females) at diagnosis was 8.8±4.4 years. Eighty-four percent of the patients were diagnosed as T1D, 5.7% as T2D, 5.3% as clinical MODY and 5% as being cases of other types of diabetes. The frequency of diabetic ketoacidosis (DKA) and severe DKA in T1D were 48.4% and 11.6%, respectively. Fourteen patients (29.2%) with T2D presented with ketosis and two of them (4.2%) had DKA at diagnosis. Antibody positivity was 83.1% in T1D and 14.8% in T2D. A statistically significant increase in the frequency of T2D has clearly been demonstrated in recent years with a frequency of 1.9%, 2.4% and 7.9% in 1999-2004, 2005-2010 and 2011-2016, respectively (p<0.001). In MODY, genetic analysis was performed in 26 (59%) patients and HNF1A and GCK gene mutations were detected in 3 (11.5%) and 14 (53.8%) patients, respectively.Conclusion:Although the most frequent cause of DM is T1D in childhood, a trend towards increase in the frequency of T2D in recent years is notable in our population.

show abstract

Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

Cited by 6 publications

References 31 publications

Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up

Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up

Undiagnosed coronary artery disease in long-term type 1 diabetes. The Dialong study

The Distribution of Different Types of Diabetes in Childhood: A Single Center Experience

Contact Info

Product

Resources

About