Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up

Fourny, Natacha; Lan, Carole; Kober, Frank; Boulghobra, Doria; Bresciani, Jordan; Reboul, Cyril; Bernard, Monique; Desrois, Martine

doi:10.1016/j.jnutbio.2019.03.022

Cited by 6 publications

(4 citation statements)

References 62 publications

(71 reference statements)

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“…We report higher heart weight-to-tibia length ratio only in M-HFS in comparison to F-HFS, which could be an indicator of cardiac hypertrophy. This result is consistent with our previous work on female Wistar rats fed with HFS diet in which we did not observe an increase in heart/tibia ratio [ 32 ]. Cardiac hypertrophy has been explained in the literature by increased collagen levels or proliferation of cardiac fibroblasts [ 43 , 44 , 45 ].…”

Section: Discussionsupporting

confidence: 94%

“…Sex differences have been reported in the development of prediabetes in terms of glucose homeostasis. Here we have shown that HFS diet induces the development of fasting hyperglycemia and glucose intolerance in HFS rats which is concordant with a previous study using the same diet in female rats [ 32 ]. However, we showed that HFS females had more pronounced glucose intolerance than HFS males with similar impaired fasting blood glucose.…”

Section: Discussionsupporting

confidence: 93%

“…Alterations in vascular response to various pharmacological agents, hypertrophic vascular remodeling and a significant decrease in eNOS expression have been reported in male rats fed with a diet high in fat and/or sugar [ 45 , 50 , 59 , 60 ]. We have previously shown the involvement of eNOS uncoupling in the decrease of coronary flow during reperfusion in HFS females, in relation with a higher oxidative stress [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury

et al. 2021

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Prediabetes is a strong predictor of type 2 diabetes and its associated cardiovascular complications, but few studies explore sexual dimorphism in this context. Here, we aim to determine whether sex influences physiological response to high-fat high-sucrose diet (HFS) and myocardial tolerance to ischemia-reperfusion injury. Male and female Wistar rats were subjected to standard (CTRL) or HFS diet for 5 months. Then, ex-vivo experiments on isolated perfused heart model were performed to evaluate tolerance to ischemia-reperfusion injury. HFS diet induced fasting hyperglycemia and increased body fat percent to a similar level in both sexes. However, glucose intolerance was more pronounced in female HFS. Cholesterol was increased only in female while male displayed higher level of plasmatic leptin. We observed increased heart weight to tibia length ratio only in males, but we showed a similar decrease in tolerance to ischemia-reperfusion injury in female and male HFS compared with respective controls, characterized by impaired cardiac function, energy metabolism and coronary flow during reperfusion. In conclusion, as soon as glucose intolerance and hyperglycemia develop, we observe higher sensitivity of hearts to ischemia-reperfusion injury without difference between males and females.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury

et al. 2021

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“…The moderate variation in macronutrient composition (only 20% fat and 20% carbohydrate) of the diet effectively reproduced hepatic oxidative stress obtained with high‐fat or high‐carbohydrate diets in rodents 48,49 . Besides, the period of life chosen for diet exposure, days of diet consumption, sex, and animal species are other variables that should be considered to try explaining the results found in our study.…”

Section: Discussionmentioning

confidence: 51%

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Jardim

Müller

Nogueira

2021

Cell Biochemistry & Function

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This study investigated whether swimming protocol induces adaptations to sex‐specific oxidative stress and Nrf2/Keap‐1 pathway in the liver of mice fed a high‐calorie diet (HCD) during the early life period. Male and female Swiss mice were fed a standard or high‐calorie (enriched with 20% lard and 20% corn syrup) diets, and the trained mice were subjected to a swimming protocol (5 days/week) from 21st to 49th postnatal days. Males fed a HCD had more pronounced alterations in all parameters evaluated than females. Although there was no increase in body weight, the fat deposition was higher in male mice exposed to diet. The intake of HCD induced dyslipidemia mainly in males. In a sex‐dependent manner, the hepatic markers of oxidative damage, antioxidant defences, and a sensitive sulfhydryl protein were altered in mice fed a HCD. Swimming counteracted dyslipidemia, hepatic oxidative stress, and the Nrf2/Keap‐1 signalling downregulation, in a sex‐dependent manner, in mice exposed to a HCD. These findings demonstrate that a non‐pharmacological therapy, swimming protocol, contributed to adaptations of sex‐specific hepatic oxidative stress and Nrf2/Keap‐1 regulation in male mice fed a HCD.

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Relationship of cardiac remodeling and perfusion alteration with hepatic lipid metabolism in a prediabetic high fat high sucrose diet female rat model

Jouenne,

Hamici,

Varlet

et al. 2023

Biochemical and Biophysical Research Communications

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Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up

Cited by 6 publications

References 62 publications

Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury

Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Relationship of cardiac remodeling and perfusion alteration with hepatic lipid metabolism in a prediabetic high fat high sucrose diet female rat model

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