Myocardial metabolism of glutamate and left ventricular function in patients with coronary arterial disease

Писаренко, О. И.; Баранов, А. В.; Pomerantsev, Eugene; Студнева, И. М.; Pavlov, Nikolay

doi:10.1016/0167-5273(89)90328-8

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…In our patients it is quite likely that the cardiac index in the G group (Table 3) increased as a consequence of this decrease in SVRI. The haemodynamic effects of glutamate infusion in the period after CABG surgery have been observed previously by others [8,23], and have even led to suggestions that glutamate infusion should form part of the treatment of severe cardiac failure after CABG surgery [3].…”

Section: Discussionmentioning

confidence: 86%

“…Intravenous glutamate infusion in the first 1 h after cardiac surgery not only improved (normalized) substrate metabolism, but in parallel also improved cardiac index and left ventricular stroke index [8,9]. Pisarenko and colleagues [3,10,11] assumed, but did not prove, that the changes in metabolism and performance after CABG surgery were mechanistically linked. They suggested that glutamate and aspartate facilitate the recovery of oxidative metabolism during reperfusion of the myocardium by activation of the malate-aspartate shuttle in the cytosol [3,[10][11][12].…”

Section: Introductionmentioning

confidence: 94%

“…Pisarenko and colleagues [3,10,11] assumed, but did not prove, that the changes in metabolism and performance after CABG surgery were mechanistically linked. They suggested that glutamate and aspartate facilitate the recovery of oxidative metabolism during reperfusion of the myocardium by activation of the malate-aspartate shuttle in the cytosol [3,[10][11][12]. This would accelerate the transfer of reducing equivalents to the respiratory chain in the mitochondria [10].…”

Section: Introductionmentioning

confidence: 95%

“…The most striking observation was a decrease in the use of blood lactate and of plasma non-esterified fatty acids (NEFA), substrates which are normally the main fuels in the healthy human heart [6]. The use of blood glucose was increased in most of the patients, and in some of the patients with severe CAD lactate was released instead of being consumed [1][2][3]. Similar abnormalities in cardiac substrate metabolism have also been observed early after coronary artery bypass graft (CABG) surgery [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that there are abnormalities in cardiac substrate metabolism in patients with coronary artery disease (CAD) [1][2][3][4][5]. The most striking observation was a decrease in the use of blood lactate and of plasma non-esterified fatty acids (NEFA), substrates which are normally the main fuels in the healthy human heart [6].…”

Section: Introductionmentioning

confidence: 99%

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The effect of glutamate infusion on cardiac performance is independent of changes in metabolism in patients undergoing routine coronary artery bypass surgery

et al. 2001

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In a double-blind randomized placebo-controlled study, the effects of intravenous glutamate infusion on myocardial haemodynamics and metabolism were studied in 22 patients undergoing routine coronary artery bypass graft (CABG) surgery. Immediately after aortic cross-clamp release, an intravenous infusion of a solution of glutamate (125 mmol x l(-1)) at a rate of 1.5 ml x h(-1) x kg(-1) was given over 1 h to 11 patients (G group). The other 11 patients received a placebo infusion (0.9% NaCl) (P group). Haemodynamic functions and rates of exchange of glucose, non-esterified fatty acids and lactic acid over the heart were measured before sternotomy (T1), 40 min after cross-clamp release (T2) and 4 h after cross-clamp release (T3). At T2, decreases were seen in comparison with T1 in systemic vascular resistance index, and increases were seen in cardiac index and coronary sinus flow. All of these changes were greater in the G group than in the P group (P<0.05). Myocardial glutamate consumption increased 2-fold after glutamate administration. No significant changes were observed in the myocardial utilization of glucose, lactate or non-esterified fatty acids between the P and the G groups at T1, T2 or T3. These data show that an intravenous glutamate infusion after routine CABG surgery significantly improved cardiac haemodynamic performance without direct effects on cardiac substrate metabolism. This suggests that a reduction of the afterload via a peripheral vasodilatory effect is the main mechanism leading to the observed changes in haemodynamics. Earlier claims that patients with post-operative cardiac failure show metabolic benefits from the glutamate infusion do not seem to apply to patients undergoing routine CABG surgery.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of glutamate infusion on cardiac performance is independent of changes in metabolism in patients undergoing routine coronary artery bypass surgery

et al. 2001

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Biochemical characterization of blood plasma of coronary artery disease patients by in vitro high-resolution proton NMR spectroscopy

et al. 2015

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This study aimed to investigate the biochemical profile of blood plasma of patients with coronary artery disease (CAD) and angiographically normal subjects (controls) to determine biomarkers for their differentiation. In this double blind study, 5 mL venous blood was drawn before angiography from CAD patients (n=60) and controls (n=13) comprising angiography normal individuals. In vitro high-resolution NMR spectroscopy of these blood plasma samples was carried out at 400 MHz, and intensity data were analysed with partial least square discriminant analysis. Categorization of subjects as controls or CAD patients and the patients further as single vessel disease (SVD), double vessel disease (DVD) and triple vessel disease (TVD) was done at the end of the study based on their angiography reports. Raised levels of lipids, alanine (Ala) and isoleucine/leucine/valine (Ile/Leu/Val) were observed in CAD patients compared with controls. Partial least square discriminant analysis showed separation between controls vs CAD patients. TVD patients showed increased levels of Ile/Leu/Val and Ala compared with controls and SVD. Alanine, Ile/Leu/Val, and LDL/VLDL appear as possible biomarkers for distinguishing between controls and patients with SVD and TVD. A metabolic adaptation of myocardium may play a role in raising the Ala level.

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Human cardiac metabolism

Bornstein,

Tian,

Arany

2024

Cell Metabolism

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Myocardial metabolism of glutamate and left ventricular function in patients with coronary arterial disease

Cited by 8 publications

References 23 publications

The effect of glutamate infusion on cardiac performance is independent of changes in metabolism in patients undergoing routine coronary artery bypass surgery

The effect of glutamate infusion on cardiac performance is independent of changes in metabolism in patients undergoing routine coronary artery bypass surgery

Biochemical characterization of blood plasma of coronary artery disease patients by in vitro high-resolution proton NMR spectroscopy

Human cardiac metabolism

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