1971
DOI: 10.1159/000169358
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Myocardial Metabolic Changes in Chronic Hypoxia

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Cited by 10 publications
(7 citation statements)
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“…Data on actual myocardial fuel substrate preferences in humans in response to high altitude and matched to appropriate control subjects are limited. However, Moret (1971/72) reported higher cardiac lactate and lower fatty acid utilization in South American individuals residing at high altitude. In agreement, lowland subjects exposed to acute altitude simulation, and rats to hypobaric hypoxia, both displayed increased glucose uptake (Hurford et al 1990; Roberts et al 1996).…”
Section: Chronic Hypoxia and Cardiac Fuel Substrate Switchingmentioning
confidence: 89%
“…Data on actual myocardial fuel substrate preferences in humans in response to high altitude and matched to appropriate control subjects are limited. However, Moret (1971/72) reported higher cardiac lactate and lower fatty acid utilization in South American individuals residing at high altitude. In agreement, lowland subjects exposed to acute altitude simulation, and rats to hypobaric hypoxia, both displayed increased glucose uptake (Hurford et al 1990; Roberts et al 1996).…”
Section: Chronic Hypoxia and Cardiac Fuel Substrate Switchingmentioning
confidence: 89%
“…Therefore, the findings would suggest that during hypoxia the same apparent cardiac power output could be maintained with a smaller aerobic energy release than during air breathing. Moret (1971) studied subjects, acclimatized to high altitude at their native altitude. He observed a lower myocardial oxygen uptake than in subjects studied at sea level and interpreted this as a sign of higher mechanical efficiency of the heart.…”
Section: Discussionmentioning
confidence: 99%
“…supply capacity of the coronary vasculature (Hartley et al 1974). Early studies of healthy humans living at altitudes of 3600-4750 m above sea level showed a more complete myocardial oxygen extraction, smaller coronary blood flow and lower myocardial oxygen consumption than in sea level residents (Moret 1971). Changes in a similar direction were found in sea level residents after 10 days ofacclimatization at 3100 m (Grover & Alexander 1976, Moret 1971/72, Grover et al 1976).…”
mentioning
confidence: 92%
“…At the same time an elevation was noted in ADP (p<0.02) and AMP content (p<0.001). Such a reduction in ATP production brings into play some substitute pathways on the one hand, and some increased efficiency of the respiratory processes at the mitochondria level on the other hand [10,11,20], We may assess that during this period the tissue is temporarily in a situation of energetic disequilibrium.…”
Section: Immediate Stage Of Adaptation (Assays Performed During the Fmentioning
confidence: 99%
“…According to these authors, this modification enters into the adaptation process concerning the glycolytic pathways among the animals exposed to an intense energy consumption. Thus during adaptation to high altitude, the cardiac muscle has to effect a considerable strain because of rapid changing of circulatory dynamics [10].…”
Section: Immediate Stage Of Adaptation (Assays Performed During the Fmentioning
confidence: 99%