Myocardial First Pass Perfusion Imaging With Gadobutrol

Theisen, Daniel; Wintersperger, Bernd J.; Huber, Armin; Dietrich, Olaf; Reiser, Maximilian; Schönberg, Stefan O.

doi:10.1097/rli.0b013e3180383572

Cited by 15 publications

(4 citation statements)

References 41 publications

(37 reference statements)

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“…Technical MR developments, such as the advent of parallel imaging algorithms or the ongoing widespread use of higher magnetic field strength certainly has an impact on first-pass myocardial perfusion imaging [95, 96]. Owing to the shortening of data acquisition intervals in the cardiac cycle using multiple element receiver-coils and parallel imaging algorithms, the frequency and severity of dark rim artefacts can be reduced, and as such, false-positive results may be potentially reduced [95].…”

Section: Mri For Cad: “The One-stop-shop”?mentioning

confidence: 99%

“…Owing to the shortening of data acquisition intervals in the cardiac cycle using multiple element receiver-coils and parallel imaging algorithms, the frequency and severity of dark rim artefacts can be reduced, and as such, false-positive results may be potentially reduced [95]. The use of 3-Tesla field strength has not only been shown to provide benefits with regard to SNR, CNR and the amplitude of the SI-time curve but also, and more importantly, a potential impact on the accuracy of first-pass myocardial perfusion results [96–99].…”

Section: Mri For Cad: “The One-stop-shop”?mentioning

confidence: 99%

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MRI and CT in the diagnosis of coronary artery disease: indications and applications

et al. 2010

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In recent years, technical advances and improvements in cardiac computed tomography (CT) and cardiac magnetic resonance imaging (MRI) have provoked increasing interest in the potential clinical role of these techniques in the non-invasive work-up of patients with suspected coronary artery disease (CAD) and correct patient selection for these emerging imaging techniques. In the primary detection or exclusion of significant CAD, e.g. in the patient with unspecific thoracic complaints, and also in patients with known CAD or advanced stages of CAD, both CT and MRI yield specific advantages. In this review, the major aspects of non-invasive MR and CT imaging in the diagnosis of CAD will be discussed. The first part describes the clinical value of contrast-enhanced non-invasive CT coronary angiography (CTCA), including the diagnostic accuracy of CTCA for the exclusion or detection of significant CAD with coronary artery stenoses that may require angioplastic intervention, as well as potentially valuable information on the coronary artery vessel wall. In the second section, the potential of CT for the imaging of myocardial viability and perfusion will be highlighted. In the third and final part, the range of applications of cardiac MRI in CAD patients will be outlined.

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Section: Mri For Cad: “The One-stop-shop”?mentioning

confidence: 99%

Section: Mri For Cad: “The One-stop-shop”?mentioning

confidence: 99%

MRI and CT in the diagnosis of coronary artery disease: indications and applications

et al. 2010

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“…Gadobutrol has also been tested for advantages in myocardial perfusion imaging on the basis that the opportunity for tighter boluses using 1.0-molar agents as appreciated in MRA should also hold true for myocardial perfusion imaging. The feasibility of gadobutrol has been proved in clinical studies; 27,28 however, in an early study the higher concentration of 1.0-molar gadobutrol did not increase the degree of signal intensity changes nor sharpen the bolus profile at the low application volumes used for myocardial perfusion imaging. 29 In this context, in a recent study of 25 CAD patients Fenchel et al…”

Section: Myocardial Perfusion Imaging In Coronary Artery Diseasementioning

confidence: 99%

Gadobutrol 1.0-molar in Cardiac Magnetic Resonance Imaging (MRI) – Further Enhancing the Capabilities of Contrast-enhanced MRI in Ischaemic and Non-ischaemic Heart Disease?

Hunold¹,

Barkhausen²

2007

European Cardiology Review

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There are many things in life everybody wants more of, and this is particularly true for magnetic resonance imaging (MRI). The major challenge in the daily life of an MRI professional is gaining maximal image signal and contrast in a reasonable amount of time. The application of gadolinium (Gd)-based MR contrast material has offered contrast features in MRI that have been used and appreciated for almost 20 years in both neurological and whole-body MRI. For example, state-of-the-art MRI is not possible in brain tumours, vascular pathologies or focal liver disease without the use of Gd. Cardiac MRI has also benefited enormously from Gd enhancement; indeed, some of the most important and established cardiac MRI applications are based on the use of Gd contrast. 1,2 Although there are strong data in support of the superiority of dedicated contrast-enhanced MRI techniques over other modalities in many clinical indications, there is still a need for improvements in image quality and stability, whether in terms of the hardware, software or 'wetware' (contrast agents). In terms of cardiac MRI, in general more contrast would be preferable since many cardiac pathologies are difficult to distinguish from normal myocardium. Therefore, the use of higher-concentration Gd compounds could improve the reliability of cardiac MRI. The aim of this article is to summarise recent knowledge about gadobutrol, the only approved 1.0-molar Gd contrast agent, in MR angiography (MRA) and neurological and whole-body MRI, and to provide an outlook on expected future developments in cardiac MRI. Gadobutrol Chemistry and Safety ProfileMost MR contrast media are based on Gd as a paramagnetic ion. The Gd 3+ ion has strong magnetic properties, which lead primarily to a T1-relaxation shortening of protons and the production of a high signal in T1-weighted MR sequences. However, the free Gd 3+ ion has to be bound in chelates to reduce unwanted side effects and create desirable pharmacokinetic properties. 3 Many Gd-based contrast agents have been clinically approved and commercially available for more than a decade. Typically, Gd agents are extracellular, non-tissue-specific, non-protein-binding, water-soluble compounds such as gadopentetate dimeglumine (Gd-DTPA), gadoteridol (Gd-HPDO3A), gadoterate (Gd-DOTA), gadoversetamide (Gd-DTPABMEA) and gadodiamide (Gd-DTPA-BMA). 4 Gadobenate dimeglumine (Gd-BOPTA) and gadofosveset, on the other hand, interact with serum albumin, resulting in a higher in vivo relaxivity and longer plasma half-lives. All of the abovementioned compounds are prepared at a concentration of 0.5mol/l.

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“…Current methods typically provide three to four 2D slices per heartbeat at stress with parallel imaging. [1][2][3] An echo planar readout can provide more than 10 slice spatial coverage with in-plane spatial resolution as high as 1.5 mm. 4 However, echo planar is sensitive to chemical shift and susceptibility effects, which thus far have prevented its use in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Myocardial perfusion MRI with an undersampled 3D stack‐of‐stars sequence

et al. 2012

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Purpose:To determine the feasibility of three-dimensional (3D) hybrid radial (stack-of-stars) MRI with spatiotemporal total variation (TV) constrained reconstruction for dynamic contrast enhanced myocardial perfusion imaging. Methods: An ECG-triggered saturation recovery turboFLASH sequence with undersampled stackof-stars sampling with spatiotemporal TV constrained reconstruction was developed for dynamic contrast enhanced myocardial perfusion imaging. Simulations were performed to study the dependence of the approach to steady state on flip angle and saturation recovery time for this stack-of-stars acquisition. Phantom studies were used to show the effect of the flip angle selection and imperfect spoiling on image qualities. Studies were done in three humans to test the feasibility of the approach for myocardial perfusion imaging. Results: The simulation and phantom studies showed that imperfect spoiling and magnetization changes during the readout were a function of flip angle and nonoptimized selection of flip angle could degrade the images. Low flip angle acquisitions in the human subjects result in images with good quality similar to multislice radial 2D images. Conclusions: 3D stack-of-stars sampling with spatiotemporal TV constrained reconstruction provides a promising alternative for myocardial perfusion imaging.

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Myocardial First Pass Perfusion Imaging With Gadobutrol

Abstract: The application of GRAPPA with an acceleration factor of R=2 leads to a significant reduction of dark rim artifacts in fast gradient recalled echo sequences.

Cited by 15 publications

References 41 publications

MRI and CT in the diagnosis of coronary artery disease: indications and applications

MRI and CT in the diagnosis of coronary artery disease: indications and applications

Gadobutrol 1.0-molar in Cardiac Magnetic Resonance Imaging (MRI) – Further Enhancing the Capabilities of Contrast-enhanced MRI in Ischaemic and Non-ischaemic Heart Disease?

Myocardial perfusion MRI with an undersampled 3D stack‐of‐stars sequence

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