Myocardial deformation parameters predict outcome in patients with repaired tetralogy of Fallot

Orwat, Stefan; Diller, Gerhard‐Paul; Kempny, Aleksander; Radke, Robert; Peters, Brigitte; Kühne, Titus; Boethig, Dietmar; Gutberlet, Matthias; Dubowy, Karl-Otto; Beerbaum, Philipp; Sarikouch, Samir; Baumgartner, Helmut

doi:10.1136/heartjnl-2015-308569

Cited by 123 publications

(87 citation statements)

References 30 publications

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“…Our risk score can be used as an initial step to differentiate low-risk from high-risk patients. The high-risk patients could be referred for additional risk assessment (including more costly and invasive investigations such as gadolinium-enhanced CMR imaging, catheterisation and/or programmed ventricular stimulation) to identify those patients who should be referred for implantable cardioverter defibrillator implantation for primary prevention 3 9 10 14 15 19 21 24. In patients without fQRS or other major risk factors, patient counselling can be matched on the excellent prognosis and follow-up may be limited to periodic assessment of residual haemodynamic lesions.…”

Section: Discussionmentioning

confidence: 99%

QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot

Bokma

Winter

Vehmeijer

et al. 2016

Heart

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Section: Discussionmentioning

confidence: 99%

QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot

Bokma

Winter

Vehmeijer

et al. 2016

Heart

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“…34 Orwat et al reported a correlation between LV and RV global systolic strain in patients with rTOF; they showed the LV-RV interaction using strain analysis measured by cardiac magnetic resonance (CMR) imaging. 29 Cheung et al also reported that the increase in RVESA correlated with the decrease in LVCS, demonstrating LV-RV interaction in patients with rTOF. 34 As the myocardial damage in RV progresses over time, it expands to include the LV and becomes severe through the LV-RV interaction.…”

Section: Mechanisms Of Decreased LV Deformation In Patients With Tofmentioning

confidence: 98%

“…Orwat et al reported that in patients with rTOF with an average age of 16 years, the strongest prognostic marker was LVCS. 29 Li et al reported that in patients with rTOF and an average age of 5.4 years, LVCS decreases significantly compared with controls, but only decreases significantly in the septal LS, not the lateral LS. 30 These reports indicate that in young patients with rTOF aged up to their teens, LVCS is an essential tool for evaluating myocardial damage, and is a prognostic marker.…”

Section: Rotation and Torsional Behaviormentioning

confidence: 99%

Mechanisms of Left Ventricular Dysfunction Assessed by Layer-Specific Strain Analysis in Patients With Repaired Tetralogy of Fallot

Yamada

Takahashi

Kobayashi

et al. 2017

Circ J

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importance of LV-RV interaction in patients who have undergone TOF repair. 8 Geva et al showed that lower LVEF and older age at repair were the strongest independent factors associated with impaired clinical status in long-term survivors of rTOF. 13 Recently, Diller et al showed that LV longitudinal dysfunction, such as impairment in longitudinal global strain and decreased mitral annular plane systolic excursion, were associated with an increased risk of sudden cardiac death and/or life threatening ventricular arrhythmias in patients with rTOF. 12 Therefore, the assessment of LV function in patients with TOF is crucial because it is the strongest determinant of a poor clinical outcome in these patients. Despite the importance of LV dysfunction, the mechanisms and time course of the development of LV dysfunction remain poorly understood. 14 Its mechanisms and time course in patients with rTOF are important because it has the potential to become T etralogy of Fallot (TOF) is the most prevalent form of cyanotic congenital heart disease. 1 Significant advances in the early management of TOF have dramatically improved the survival of TOF patients, 2 with current 30-year survival rates reaching 89%. 3 However, late ventricular dysfunction related to residual hemodynamic and electrophysiological abnormalities remains a problem, contributing to increasing morbidity and mortality rates beginning in the third decade of life. 2,4-6 Previous investigators assessing ventricular function in patients with repaired TOF (rTOF) have primarily focused on right ventricular (RV) mechanics and their interaction with pulmonary regurgitation (PR). 7-9 Moreover, the importance of left ventricular (LV) dysfunction as a risk factor for long-term adverse outcomes is increasingly acknowledged. (rTOF) is an important risk factor for adverse outcomes. The aim of this study was to assess the details and time course of such LV dysfunction using layer-specific strain analysis by echocardiography.

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“…Associations of LV GLS, GCS, GRS, and RV GLS with death and nearly missed death were recently prospectively demonstrated in a large cohort of repaired TOF at a median follow-up of 7.4 years. 56 There is also evidence from STE to suggest that quantitative measures of LA function carry prognostic information. 57 From an inception cohort of the MESA study, it was shown that impairment of LA function precedes development of heart failure in the general population.…”

Section: Prognostic Implicationsmentioning

confidence: 99%

Cardiovascular Magnetic Resonance Myocardial Feature Tracking

Schuster

Hor

Kowallick

et al. 2016

Circ: Cardiovascular Imaging

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289

200

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Abstract-Heart failure-induced cardiovascular morbidity and mortality constitute a major health problem worldwide and result from diverse pathogeneses, including coronary artery disease, nonischemic cardiomyopathies, and arrhythmias. Assessment of cardiovascular performance is important for early diagnosis and accurate management of patients at risk of heart failure. During the past decade, cardiovascular magnetic resonance myocardial feature tracking has emerged as a useful tool for the quantitative evaluation of cardiovascular function. The method allows quantification of biatrial and biventricular mechanics from measures of deformation: strain, torsion, and dyssynchrony. The purpose of this article is to review the basic principles, clinical applications, accuracy, and reproducibility of cardiovascular magnetic resonance myocardial feature tracking, highlighting the prognostic implications. It will also provide an outlook on how this field might evolve in the future. (Circ Cardiovasc Imaging. 2016;9:e004077.

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Myocardial deformation parameters predict outcome in patients with repaired tetralogy of Fallot

Abstract: http://www.clinicaltrials.gov: NCT00266188; Results.

Cited by 123 publications

References 30 publications

QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot

QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot

Mechanisms of Left Ventricular Dysfunction Assessed by Layer-Specific Strain Analysis in Patients With Repaired Tetralogy of Fallot

Cardiovascular Magnetic Resonance Myocardial Feature Tracking

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