Myocardial Contrast Echocardiography

Kaul, Sanjiv

doi:10.1161/circulationaha.107.747303

Cited by 117 publications

(78 citation statements)

References 133 publications

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“…For over three decades, UCAs have been clinically used to enhance ultrasound (US) imaging in different fields, such as cardiology and radiology [1,2]. Targeted UCAs (tUCAs) differ from clinically approved UCAs by the decoration of their shell with targeting ligands [3].…”

Section: Introductionmentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to their surface to target specific biomarkers of a disease or a disease process. These targeted UCAs (tUCAs) are used for a wide range of pre-clinical applications including diagnosis, monitoring of drug treatment, and therapy. In this review, recent achievements with tUCAs in the field of molecular imaging, evaluation of therapy, drug delivery, and therapeutic applications are discussed. We present the different coating materials and aspects that have to be considered when manufacturing tUCAs. Next to tUCA design and the choice of ligands for specific biomarkers, additional techniques are discussed that are applied to improve binding of the tUCAs to their target and to quantify the strength of this bond. As imaging techniques rely on the specific behaviour of tUCAs in an ultrasound field, it is crucial to understand the characteristics of both free and adhered tUCAs. To image and quantify the adhered tUCAs, the state-of-the-art techniques used for ultrasound molecular imaging and quantification are presented. This review concludes with the potential of tUCAs for drug delivery and therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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“…The description of such uses has been reviewed recently in detail. 14 Technical aspects of ultrasound contrast agent administration, applications, and …”

Section: The Need For Contrast Echocardiography In Clinical Practicementioning

confidence: 99%

Overview of the 2008 Food and Drug Administration Advisory Committee on Safety Considerations in the Development of Ultrasound Contrast Agents

Asch

Weissman

2009

Circulation

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“…2 The ability of contrast agents, which contain microbubbles that mimic red blood cell rheology, to enable visualization of myocardial perfusion resulted in rapid development of both microbubble and equipment technology that allowed the use of contrast echocardiography for the detection of myocardial perfusion in clinical cardiology. 3 Numerous single and multicenter studies have proved that myocardial contrast perfusion stress echocardiography is now a clinical tool for the detection of CAD. 4 The ability of myocardial contrast SE to assess function and perfusion simultaneously makes it a unique technique for the assessment of CAD.…”

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confidence: 99%