Myocardial aneurysm in association with disseminated cytomegalovirus infection

Sánchez, Guillermo R.; Neches, William H.; Jaffe, Ronald

doi:10.1007/bf02265619

Cited by 13 publications

(3 citation statements)

References 16 publications

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“…However, the factors that govern the severity of atrial infection were unclear. There have been infrequent reports of HCMV infection of the heart in perinatally infected infants [10,22]. However, given the severity of the disease we observed and the similarities between the human and mouse model, it would be worthwhile to further investigate the level and distribution of cardiac involvement in HCMV-infected infants.…”

Section: Discussionmentioning

confidence: 82%

Cytomegalovirus-induced pneumonitis and myocarditis in newborn mice

Fitzgerald

Papadimitriou

Shellam

1990

Archives of Virology

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Genetically determined resistance to the lethal effects of infection with murine cytomegalovirus (MCMV) has been reported previously in adult and newborn mice. We examined the pathogenesis of MCMV infection in resistant (CBA, H-2k) and susceptible (BALB/c, H-2d) mice infected intraperitoneally on the day of birth. BALB/c mice developed a severe interstitial pneumonitis and myocarditis 10 days post-infection. Their pulmonary and tissues contained high MCMV titres and large numbers of MCMV-antigen positive cells. MCMV also infected the endothelial and myointimal cells of the coronary arteries in newborn BALB/c mice. Only limited infection and pathological changes were seen in CBA mice. Since the severe disease in BALB/c mice resembles the pneumonitis and less frequently reported myocarditis observed after perinatal HCMV infection, the newborn mouse model will be useful for studying the consequences and treatment of such infections, the influence of the host genotype on disease severity and the possible association between perinatal HCMV infection and atherosclerosis.

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Section: Discussionmentioning

confidence: 82%

Cytomegalovirus-induced pneumonitis and myocarditis in newborn mice

Fitzgerald

Papadimitriou

Shellam

1990

Archives of Virology

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“…Cytomegalovirus nucleic acids were determined in myocytes of the majority of the cases with fatal myocarditis (4). The histologic features of myocarditis associated with CMV or other infectious agents consist of inflammatory infiltrates and necrosis of myocytes (5). Chronic viral myocardial infections including CMV were accused of causing dilated cardiomyopathy through partially unknown mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic Cardiomyopathy As A Clinical Component of Congenital Cytomegalovirus Infection

et al. 2015

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We report hypertrophic cardiomyopathy in a newborn with congenital cytomegalovirus infection. The neonate had distinct signs of congenital cytomegalovirus infection including petechiae, jaundice, intracranial calcifications, cerebral ventriculomegaly and chorioretinitis together with hypertrophic cardiomyopathy. Following determination of anti-cytomegalovirus IgM, viral DNA was also isolated from the plasma of the patient by polymerase chain reaction. Although cytomegalovirus is a relatively frequent cause of myocarditis in childhood, it was rarely reported to be associated with cardiac abnormalities such as structural heart disease, atrioventricular block, or dilated cardiomyopathy. To our knowledge, this is the first case with congenital cytomegalovirus infection and hypertrophic cardiomyopathy.

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“…The cases described so far have occurred mostly in connection with myocardial infarc tion in association with the abnormal origin of the left coronary artery [9-13], after [14,15], with infectious disease [8. 16-18] or parasitic (Echinococcus) [19,20] and in Chagas' disease [22].…”

Section: Discussionmentioning

confidence: 99%

Calcified Left Ventricular Aneurysm in a 6-Year-Old Boy

Oberhänsli¹,

Cox²,

Faidutti³

et al. 1983

Cardiology

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The case of a calcified left ventricular aneurysm in a 6-year-old asymptomatic boy is presented. The anomaly was discovered on a routine chest X-ray. The etiology of this condition is discussed. A review of the literature reveals that this is a rare occurrence in children and that the origin is often unknown. Selective left coronary arteriography showed no arterial anomalies but early filling of the right coronary veins, apparently through small AV fistulas. This might have caused some peripheral myocardial underperfusion, followed by myocardial infarction and aneurysm formation. Aneurysmectomy was carried out uneventfully.

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Myocardial aneurysm in association with disseminated cytomegalovirus infection

Cited by 13 publications

References 16 publications

Cytomegalovirus-induced pneumonitis and myocarditis in newborn mice

Cytomegalovirus-induced pneumonitis and myocarditis in newborn mice

Hypertrophic Cardiomyopathy As A Clinical Component of Congenital Cytomegalovirus Infection

Calcified Left Ventricular Aneurysm in a 6-Year-Old Boy

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