Myoblast transplantation for myocardial repair: a clinical case

Trainini, Jorge C.; Lago, Noemí; Paz, Jorge de; Cichero, Daniel; Giordano, Roberto; Mouras, Jorge; Barisani, José Luis; Christen, Alejandra; Chachques, Juan Carlos

doi:10.1016/s1053-2498(03)00221-3

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…Notably, autologous transplantation of skeletal muscle has been shown to reverse LV remodeling. [17][18][19] However, this approach has been complicated by the induction of arrhythmias that may be due to the lack of electromechanical coupling between the injected skeletal muscle cells and the native myocardium. 20 Another therapeutic approach is to repopulate the infarcted myocardium by direct injection with the patient's own bone marrow progenitor cells.…”

Section: Discussionmentioning

confidence: 99%

Grafting an Acellular 3-Dimensional Collagen Scaffold Onto a Non-transmural Infarcted Myocardium Induces Neo-angiogenesis and Reduces Cardiac Remodeling

Gaballa

Sunkomat

Thai

et al. 2006

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Grafting an Acellular 3-Dimensional Collagen Scaffold Onto a Non-transmural Infarcted Myocardium Induces Neo-angiogenesis and Reduces Cardiac Remodeling

Gaballa

Sunkomat

Thai

et al. 2006

The Journal of Heart and Lung Transplantation

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“…Since June 2000, more than 200 patients with ischemic myocardial disease and some with non-ischemic dilated cardiomyopathy have been treated in Europe, the Americas, and Asia. 4,33 –42 The number of surgical implantations was equivalent to those of percutaneous catheter-based procedures, and the number of patients treated with autologous skeletal myoblasts was equivalent to those treated with bone marrow cells. However, there is a tendency to use bone marrow cells for myocardial regeneration since this approach avoids the 3-week cell-culture procedure and the risk of ventricular arrhythmias and sudden death observed after skeletal myoblast transplantation.…”

Section: Clinical Trialsmentioning

confidence: 99%

Cellular Cardiomyoplasty for Myocardial Regeneration

Chachques

Salanson-Lajos

Lajos

et al. 2005

Asian Cardiovasc Thorac Ann

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The evolving challenge of managing patients with congestive heart failure is the need to develop new therapeutic strategies. The cellular, molecular, and genetic approaches investigated aim to reinforce the weak, failing heart muscle while restoring its functional potential. This approach is principally cellular therapy (i.e. cellular cardiomyoplasty), the preferred therapeutic choice because of its clinical applicability and regenerative capacity. Different stem cells: bone marrow cells, skeletal and smooth muscle cells, vascular endothelial cells, mesothelial cells, adipose tissue stroma cells, dental stem cells, and embryonic and fetal cells, have been proposed for regenerative medicine and biology. Stem cell mobilization with G-CSF cytokine was also proposed as a single therapy for myocardial infarction. We investigated the association of cell therapy with electrostimulation (dynamic cellular cardiomyoplasty), the use of autologous human serum for cell cultures, and a new catheter for simultaneous infarct detection and cell delivery. Our team conducted cell-based myogenic and angiogenic clinical trials for chronic ischemic heart disease. Cellular cardiomyoplasty constitutes a new approach for myocardial regeneration; the ultimate goal is to avoid the progression of ventricular remodeling and heart failure for patients presenting with ischemic and non-ischemic cardiomyopathies.

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“…Cell transplantation is becoming recognized as a viable strategy to improve myocardial viability and limit infarct growth [23][24][25][26]. Cultured autologous cells do not raise immunological, ethical, tumorogenesis or donor-availability problems.…”

Section: Perspectivesmentioning

confidence: 99%

Cellular cardiomyoplasty for myocardial support and regeneration

et al. 2004

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Zusammenfassung. Grundlagen: Die Regeneration von avitalem Myokard durch Zellimplantation gewinnt zunehmend an wissenschaftlichem Interesse.Methodik: Myoblasten, mesenchymale und embryonale Stammzellen und andere Vorläuferzellen werden derzeit in verschiedenen experimentellen Settings untersucht. Ein Überblick über den Status quo wird dargestellt.Ergebnisse: Etwa 200 Patienten wurden mit verschiedenen Techniken behandelt. Derzeit können nur vorläufige Ergebnisse aufgezeigt werden.Schlussfolgerungen: Die Idee, die Regeneration von geschädigtem Myokard durch Zellimplantation herbeizuführen, ist faszinierend. Verschiedenste Zelltypen werden in unterschiedlichen experimentellen Settings angewandt. Die zelluläre Kardiomyoplastie scheint die Größe und den Fibrosegehalt in postischämischen Narben zu reduzieren. Wie sich diese Therapiemöglichkeit entwickeln wird, kann derzeit noch nicht abgeschätzt werden Schlüsselwörter: zelluläre Kardiomyoplastie, Herzinsuffizienz, Stammzellen.Summary. Background: Cell-based regenerative therapy is undergoing different experimental and clinical trials in order to limit the consequences of decreased contractile function and compliance of damaged ventricles following myocardial infarction.Methods: An overview of the actual status quo. Results: Over 200 patients have been treated worldwide with cell-based procedures for myocardial regeneration. Results are preliminary.Conclusions: Cellular cardiomyoplasty seems to reduce the size and fibrosis of infarct scars, limit postischemic remodelling, and restore regional myocardial contractility.

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Myoblast transplantation for myocardial repair: a clinical case

Cited by 7 publications

References 7 publications

Grafting an Acellular 3-Dimensional Collagen Scaffold Onto a Non-transmural Infarcted Myocardium Induces Neo-angiogenesis and Reduces Cardiac Remodeling

Grafting an Acellular 3-Dimensional Collagen Scaffold Onto a Non-transmural Infarcted Myocardium Induces Neo-angiogenesis and Reduces Cardiac Remodeling

Cellular Cardiomyoplasty for Myocardial Regeneration

Cellular cardiomyoplasty for myocardial support and regeneration

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