Cellular Cardiomyoplasty for Myocardial Regeneration

Abstract

The evolving challenge of managing patients with congestive heart failure is the need to develop new therapeutic strategies. The cellular, molecular, and genetic approaches investigated aim to reinforce the weak, failing heart muscle while restoring its functional potential. This approach is principally cellular therapy (i.e. cellular cardiomyoplasty), the preferred therapeutic choice because of its clinical applicability and regenerative capacity. Different stem cells: bone marrow cells, skeletal and smooth muscle cells, vascular endothelial cells, mesothelial cells, adipose tissue stroma cells, dental stem cells, and embryonic and fetal cells, have been proposed for regenerative medicine and biology. Stem cell mobilization with G-CSF cytokine was also proposed as a single therapy for myocardial infarction. We investigated the association of cell therapy with electrostimulation (dynamic cellular cardiomyoplasty), the use of autologous human serum for cell cultures, and a new catheter for simultaneous infarct detection and cell delivery. Our team conducted cell-based myogenic and angiogenic clinical trials for chronic ischemic heart disease. Cellular cardiomyoplasty constitutes a new approach for myocardial regeneration; the ultimate goal is to avoid the progression of ventricular remodeling and heart failure for patients presenting with ischemic and non-ischemic cardiomyopathies.

“Flow and Rate”: Concept and Clinical Applications of a New Hemodynamic Theory

“…In case of disturbed hemodynamic with heart failure, additional circulatory driving forces might be needed such as: a) Bio-assists with surgical procedures like the aortomyoplasty (Bolotin, et al (2001), cardiomyoplasty (Chachques, et al,2005), and heterotopic heart transplants (Onuzo, et al, 2000); and/or b) mechanical assists devices: like the cardiopulmonary bypass (CPB), left ventricular assist device (LVAD) (Seyfarth, et al, 2008)or right ventricular assist device (RVAD), and the artificial heart (Unger, et al,1988).…”

Culture of human dental pulp cells at variable times post-tooth extraction

“…Besides that, DPSCs were effective in regenerating bone tissue, 14,15,16 hair follicles, 17 heart muscle, 18,19 neu rona l cel ls, 20 a nd cor nea l epit hel iu m. 21 Furthermore, these stem cells are immunoprivileged and have the ability to modulate immune and inflammatory responses.…”

Bypass Grafts and Cell Transplant in Heart Failure with Low Ejection Fraction

“…The mechanisms involved in adult stem cell differentiation are unclear. [11][12][13][14] The possibility of promoting the development of cardiomyocytes in the adult heart is considered a promising strategy for the treatment of heart failure or ischemic heart disease. 15 In November 2004, we started a program of cellular transplantation combined with coronary artery bypass grafting (CABG) for patients with severe ischemic heart failure.…”