1992
DOI: 10.1111/j.1349-7006.1992.tb01981.x
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Myeloprotective Activity of Deoxyspergualin: Influence on Splenic Colony‐forming Cell Injury and Antitumor Activity of Mitomycin C in Mice

Abstract: We have examined the efficacy of deoxyspergualin (DSG) in protecting splenic colony‐forming cells (CFU‐S) from mitomycin C (MMC)‐induced damage. The main findings of the study are as follows. (1) When DSG was administered at doses of 1.5 and 3 mg/kg for 7 days before the MMC injection, the decrease of the femoral CFU‐S caused by MMC was diminished on the day after the MMC injection. The optimal dose was found to be 3 mg/kg. (2) In animals receiving 3 mg/kg DSG for at least 3 days preceding the MMC injection, t… Show more

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Cited by 5 publications
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“…DSG pretreatment had a minor suppressive effect on all immunotoxin-induced hematologic changes and ameliorated the elevated hematocrit induced by BR96 sFv-PE40 (Table 4). However, DSG caused a pronounced decrease in monocytes consistent with the general myelosuppression effect of DSG that had been previously reported (19).…”
supporting
confidence: 88%
“…DSG pretreatment had a minor suppressive effect on all immunotoxin-induced hematologic changes and ameliorated the elevated hematocrit induced by BR96 sFv-PE40 (Table 4). However, DSG caused a pronounced decrease in monocytes consistent with the general myelosuppression effect of DSG that had been previously reported (19).…”
supporting
confidence: 88%