Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms

Andelid, Kristina; Bake, Björn; Rak, S.; Lindén, Anders; Rosengren, Annika; Ekberg-Jansson, Ann

doi:10.1016/j.rmed.2006.09.023

Cited by 62 publications

(50 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, MPO itself and MPO-derived reactive oxygen species have been shown to increase the expression of tissue factor, leading to a thrombotic state 91) , and influence erythrocyte deformation and aggregation, leading to membrane generation, rouleau formation and higher blood viscosity [92][93][94][95][96][97] . In addition, other cardiovascular risk factors (cigarette smoking, hyperglycemia) [98][99][100][101][102][103][104][105] and immune-inflammatory/oxidative stress-related factors (C-reactive protein, CD40 ligand, fibrinogen and D-dimer, lipoprotein (a)) 81, [106][107][108][109][110][111][112][113][114][115][116][117][118] have been reported to influence the platelet-fibrin clot structure and blood viscosity/erythrocyte aggregation. These findings are of considerable interest, since they suggest that some factors influencing blood thrombogenicity/ viscosity and erythrocyte properties (deformability and/or aggregability) may play important roles in the evolution of erythrocyte-rich large thrombi.…”

Section: )mentioning

confidence: 99%

Thrombus Aspiration Therapy and Coronary Thrombus Components in Patients with Acute ST-Elevation Myocardial Infarction

Yunoki

Naruko

Sugioka

et al. 2013

JAT

View full text Add to dashboard Cite

Inflammation and oxidative stress play key roles in atherosclerotic plaque instability, and plaque rupture/erosion and subsequent thrombus formation constitute the principal mechanisms of total vessel occlusion and acute ST-elevation myocardial infarction (STEMI). Plaque disruption triggers the formation of initial platelet aggregates that grow in association with an increase in fibrin formation, leading to persistent coronary flow obstruction and blood coagulation. The fibrin network may trap large numbers of erythrocytes and inflammatory cells to form an erythrocyte-rich thrombus. In fact, previous clinical studies have shown that not only platelet-rich white thrombi, but also erythrocyte-rich red thrombi can be visualized using angioscopy in patients with acute coronary syndrome. Recently, the development of thrombus aspiration and distal protection devices has significantly improved the clinical outcomes of percutaneous intervention in STEMI patients and has enabled the evaluation of antemortem coronary artery thrombi. This is important because previous autopsy studies were unable to differentiate coronary thrombi responsible for myocardial ischemia from postmortem clots. Using frozen samples of aspirated thrombi and specific monoclonal antibodies, we investigated the cellular components of thrombi (platelets, erythrocytes, fibrin and inflammatory cells, such as myeloperoxidase-positive cells) and pathologically evaluated the relationships between erythrocyterich thrombi and inflammation, oxidative stress and clinical outcomes in STEMI patients. Therefore, this review article focuses on the efficacy of thrombus aspiration therapy and the components of aspirated intracoronary thrombi in STEMI patients and presents the results of recent studies regarding the relationship between the composition of aspirated intracoronary thrombi and clinical outcomes.

show abstract

Section: )mentioning

confidence: 99%

Thrombus Aspiration Therapy and Coronary Thrombus Components in Patients with Acute ST-Elevation Myocardial Infarction

Yunoki

Naruko

Sugioka

et al. 2013

JAT

View full text Add to dashboard Cite

show abstract

“…For example, neutrophil elastase is able to degrade insoluble elastin and MPO mediates the bactericidal effects of neutrophils. Furthermore, both neutrophil elastase and MPO favour tissue destruction in COPD [34,35]. Therefore, NLR has been investigated as a putative marker of disease severity and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

et al. 2018

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

show abstract

“…Risk of future CAD increased in consecutive quartiles of MPO concentration with an odds ratio of 1.49 in a report published by the Epic-Norfolk prospective population study 37 .Also MPO was found to be an early marker of systemic inflammation in a 6 year follow up study in smokers without severe airway symptoms 38 .…”

Section: Discussionmentioning

confidence: 90%

Leukocyte myeloperoxidase activity and serum CRP levels as predictive markers of inflammatory disorders amongst Passive smokers

Kumarchandra

Bhandari

Prassanna

et al. 2013

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Aims and objectives: To analyse the leukocyte myeloperoxidase activity and serum C-reactive protein levels in smokers, passive smokers and non-smokers and to evaluate the risk of developing inflammation that may lead to lung cancer in smokers in general and passive smokers in particular, by comparing the levels with nonsmokers

Methodology:.Study design comprised of three groups;active smokers(Smokers who have smoked more than 5 cigarettes/ day for a minimum period of 2 years.) passive smokers(Smokers exposed to smoke for a duration of >30 minutes/day, ≥5 days a week for one year or more (waiters in a pub/restaurant) and controls (non smokers). All patients with puemococcal infections were eliminated from the study .Leukocyte MPO & serum CRP (semiquantitative assay) were performed with patient s samples. Data was analysed by ANOVA followed by post hoc tests. Odds ratio was also calculated for the study groups.

Results: There was no significance in the study groups with respect to both MPO as well as CRP.

Conclusion : CRP or MPO may not be the ideal markers to predict the probability of developing an inflammatory disorder in persons exposed to passive smoke.

show abstract

Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms

Cited by 62 publications

References 39 publications

Thrombus Aspiration Therapy and Coronary Thrombus Components in Patients with Acute ST-Elevation Myocardial Infarction

Thrombus Aspiration Therapy and Coronary Thrombus Components in Patients with Acute ST-Elevation Myocardial Infarction

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

Leukocyte myeloperoxidase activity and serum CRP levels as predictive markers of inflammatory disorders amongst Passive smokers

Contact Info

Product

Resources

About