Leukocyte myeloperoxidase activity and serum CRP levels as predictive markers of inflammatory disorders amongst Passive smokers

Abstract

<p><strong>Aims and objectives: </strong>To analyse the leukocyte myeloperoxidase activity and serum C-reactive protein levels in smokers, passive smokers and non-smokers and to evaluate the risk of developing inflammation that may lead to lung cancer in smokers in general and passive smokers in particular, by comparing the levels with nonsmokers</p><p><strong>Methodology</strong>:.Study design comprised of three groups;active smokers(Smokers who have smoked more than 5 cigarettes/ day for a minimum period of 2 years.) passive smokers(Smokers exposed to smoke for a duration of >30 minutes/day, ≥5 days a week for one year or more (waiters in a pub/restaurant) and controls (non smokers). All patients with puemococcal infections were eliminated from the study .Leukocyte MPO &amp; serum CRP (semiquantitative assay) were performed with patient s samples. Data was analysed by ANOVA followed by post hoc tests. Odds ratio was also calculated for the study groups.</p><p><strong>Results</strong>: There was no significance in the study groups with respect to both MPO as well as CRP.</p><p><strong>Conclusion</strong> : CRP or MPO may not be the ideal markers to predict the probability of developing an inflammatory disorder in persons exposed to passive smoke.</p