Myeloma cells in the cerebrospinal fluid in plasma cell neoplasia

Abstract

From Cairo, Egypt SYNOPSIS Myeloma cells were detected in the cerebrospinal fluid of two patients with plasma cell neoplasia during the myelographic studies of 38 patients whose myeloma was associated with extensive neurological complications. The myeloma cells were looked for in Wright stained centrifuged deposit of 2-5 ml samples of the cerebrospinal fluid obtained during myelography. The possibility that occult traumatic lumbar puncture had allowed entry of circulating myeloma cells from the peripheral blood into the subarachnoid space was excluded by the absence of myeloma cells in smears of peripheral blood and its buffy coat. Up to the end stages of the disease the meningeal myeloma lesions remained microscopical and no signs of raised intracranial tension were manifested by either patient.

Cerebral involvement in multiple myeloma: case report.

“…In contrast, infiltration of the leptomeninges in multiple myeloma seems to be rare. We could find only two reported cases (Afifi, 1974;Maldonado et al, 1970).…”

“…Meningeal myeloma is presumed to develop as a result of neoplastic proliferation into myeloma cells of the totipotent mesenchymal cells accompanying the pial blood vessels. This mechanism may be held responsible for the development of both isolated meningeal myeloma and meningeal lesions complicating systemic myelomatosis (Afifi, 1974). Cerebral myeloma occurring early in the disease is extremely rare.…”

Meningeal Involvement in Multiple Myeloma

“…Table II shows the case reports of central nervous system in volvement in multiple myeloma. Meningeal infiltration of myeloma cells was diagnosed histologically at the time of autopsy in the cases reported by Ben-Bassat et al [2] and Maldonado et al [5], Afifi [1] reported 2 myeloma patients who had muscle weak ness. Cytological examinations revealed myeloma cell infiltration into the CSF with out plasma cells in the peripheral blood.…”

Meningeal Involvement in Multiple Myeloma

“…[1][2][3][4]7,9,[11][12][13][16][17][18][21][22][23]25,27,[29][30][31][32][36][37][38][39][40][42][43][44][45][46] Our case is the 38th. The immunoglobulin types reported involved IgG, IgA, IgD and light chain; our case is the fourth report of light chain myeloma with meningeal involvement.…”