Myeloma‐associated systemic amyloidosis presenting with acquired digital cutis laxa‐like changes

Dicker, Tony; Morton, James; Williamson, Richard; Chick, J. E. D.

doi:10.1046/j.1440-0960.2002.00579.x

Cited by 27 publications

(18 citation statements)

References 10 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, many other cutaneous clinical manifestations have been reported. Among them, alopecia, 109-111 cutis laxa, [112][113][114][115] or bullae. [116][117][118][119][120][121][122][123][124] Blisters are also frequent due to cleavage developing within the amyloid deposits and many times are hemorrhagic and occur on the tongue or bucal mucosa (Fig.…”

Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.

show abstract

Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…Acquired cutis laxa can occur following febrile illness, urticaria and angiedema, extensive inflammatory dermatoses, such as systemic lupus erythematosus (SLE) or erythema multiforme, multiple myeloma, insect bite, complement deficiency, sarcoidosis, syphilis, dermatitis herpetiformis and, rarely, in association with systemic amyloidosis, nephrotic syndrome, Klippel-Trenaunay syndrome, rheumatoid arthritis, plasma cell dyscrasia, celiac disease, and angiocentric T-cell lymphoma. [1][2][3][4][5][6][7] Its association with Lyme borreliosis has also been suggested. 8 It may also follow hypersensitivity reaction to penicillin and treatment with isoniazid 9 (INH) or penicillamine.…”

Section: Discussionmentioning

confidence: 99%

Cutis laxa acquisita associated with cutaneous mastocytosis

2006

View full text Add to dashboard Cite

A female child, a product of a nonconsanguineous parentage and normal pregnancy, was seen first at the age of 4 years. She had suffered from recurrent episodes of multiple, erythematous, confluent plaques and a few bullous lesions all over the body since infancy. The child was irritable but had no history of flushing, dyspnea, wheezing, or frequent diarrhea. Darier's sign was strongly positive and systemic examination did not reveal any abnormality. Routine laboratory investigations were normal and a skin biopsy specimen revealed an unremarkable epidermis and dense proliferation of round to spindle‐shaped mast cells which stained positive for metachromatic granules (Fig. 1). With the diagnosis of urticaria pigmentosa, she was managed with antihistaminic drugs and the parents were advised to handle the child gently. She did not report for further follow‐up. 1 Photomicrograph of skin histology showing metachromatic granules (toluidine blue, ×40) Recently, the child, now 8 years of age, was brought again with finely wrinkled, lax, and redundant skin, especially of the face, giving her a senile appearance (Fig. 2). Systemic examination did not show any abnormality. History revealed that the child had been asymptomatic during the last 4 years even without treatment, but developed slowly progressive lax and pendulous skin. A repeat biopsy from the lax facial skin revealed sparse and fragmented elastic fibres, normal collagen, and a perivascular and intradermal cellular infiltrate composed of metachromatic mast cells. Her serum α1‐antitrypsin levels were 190.0 mg/dL (normal, 93–224 mg/dL) and a pulmonary function test showed no abnormality. Treatment with antihistaminic drugs was started again and she was advised to have a cosmetic facial uplift at a later stage. 2 Patient with urticaria pigmentosa seen at 8 years of age showing cutis laxa and a senile appearance

show abstract

“…2,[12][13][14][15][16]33,34 Other reported associations include penicillin, penicillamine, or isoniazid therapy; diabetes mellitus; systemic amyloidosis; rheumatoid arthritis; celiac disease; and Borrelia burgdorferi infection. 1,3,15,22,[35][36][37][38][39][40][41] Finally, cutis laxa has been associated with renal changes, including diffuse glomerulosclerosis with arteriolar nephrosclerosis and nephrotic syndrome with membranoproliferative glomerulonephritis. 11,14 The cause of acquired cutis laxa is unknown, and multiple etiologies have been proposed.…”

Section: Commentmentioning

confidence: 99%