Myeloid-related protein 8/14 and high-sensitivity cardiac troponin I to differentiate type 2 myocardial infarction

Bormann, J; Psyrakis, Dimitrios; Jeinsen, Beatrice von; Grün, Dimitri; Elsner, Laura; Wolter, Jan Sebastian; Weferling, Maren; Diouf, Katharina; Kriechbaum, Steffen; Troidl, Christian; Dörr, Oliver; Nef, Holger; Hamm, Christian W.; Liebetrau, Christoph; Keller, Till

doi:10.1016/j.ijcard.2020.01.043

Cited by 8 publications

(10 citation statements)

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“…The first cohort, referred to as the acute coronary syndrome (ACS) cohort, utilized data and biomaterial from a prospective, multicenter biomarker registry that enrolled patients presenting with suspected acute MI between August 2011 and October 2016, as described previously ( 11 ). Here, the final gold-standard study diagnosis, including type of MI, was made independently by two cardiologists based on the Third Universal Definition of Myocardial Infarction ( 9 ) using all available clinical, laboratory, and imaging data.…”

Section: Methodsmentioning

confidence: 99%

Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction

Askari

Lipps

Voss

et al. 2021

Front. Cardiovasc. Med.

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Inflammation is a hallmark of the period after a myocardial infarction (MI) that is either promoted or resolved by distinct subtypes of circulating inflammatory cells. The three main monocyte subpopulations play different roles inflammation. This study examined whether the type of MI (type 1 or type 2) or the extent of myocardial injury is associated with differences in monocyte subpopulations. For this purpose, peripheral whole blood from patients with a suspected MI was used for flow cytometric measurements of the monocyte subpopulations, and myocardial injury was classified by cardiac troponin levels in serum. In patients with acute coronary syndrome (n = 82, 62.2% male) similar proportions of the monocyte subsets were associated with the two types of MI, whereas total monocyte counts were increased in patients with substantial myocardial injury vs. those with minor injury (p = 0.045). This was accompanied by a higher proportion of intermediate (p = 0.045) and classical monocytes (p = 0.059); no difference was found for non-classical monocytes (p = 0.772). In patients with chronic coronary syndrome (n = 144, 66.5% male), an independent association with myocardial injury was also observed for classical monocytes (p = 0.01) and intermediate monocytes (p = 0.08). In conclusion, changes in monocyte subpopulation counts, particularly for classical and intermediate monocytes, were related to the extent of myocardial injury in acute and stable coronary artery disease but not to the type of MI.

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Section: Methodsmentioning

confidence: 99%

Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction

Askari

Lipps

Voss

et al. 2021

Front. Cardiovasc. Med.

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“…Furthermore, protein biomarkers can provide significant diagnostic information for MI, which is crucial for follow-up treatment. For instance, myeloid-related protein 8/14 (MRP-8/14) was found to have higher concentrations, and high-sensitivity cardiac troponin I (hs-cTnI) to have lower concentrations in type 2 MI compared to type 1 MI ( 179 ). Pandey et al ( 180 ) demonstrated that the levels of cTnT and CK-MB were significantly higher in patients with type 1 MI than in those with type 2 MI, and cTnT increased disproportionately with CK-MB in type 2 MI patients.…”

Section: Single-omics Approachesmentioning

confidence: 99%

From multi-omics approaches to personalized medicine in myocardial infarction

Zhan,

Tang,

et al. 2023

Front. Cardiovasc. Med.

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Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, and sudden death. Despite being a research hotspot, the etiological mechanism of MI remains unclear. The emergence and widespread use of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other omics, have provided new opportunities for exploring the molecular mechanism of MI and identifying a large number of disease biomarkers. However, a single-omics approach has limitations in understanding the complex biological pathways of diseases. The multi-omics approach can reveal the interaction network among molecules at various levels and overcome the limitations of the single-omics approaches. This review focuses on the omics studies of MI, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and other omics. The exploration extended into the domain of multi-omics integrative analysis, accompanied by a compilation of diverse online resources, databases, and tools conducive to these investigations. Additionally, we discussed the role and prospects of multi-omics approaches in personalized medicine, highlighting the potential for improving diagnosis, treatment, and prognosis of MI.

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“…Так, Bormann et al проводилось исследование диагностической значимости С-реактивного белка (СРБ). Выявлено значительное повышение СРБ у пациентов с ИМ 2 типа (n=55) по сравнению с пациентами с ИМ 1 типа (n=199) (0,6 против 0,3, р=0,02) [8].…”

Section: Introductionunclassified

Type 2 Myocardial Infarction on the Background of Coronary Vasospasm and Invasive Tactics of Its Diagnosis and Treatment

Gamayunov,

Kalyagin,

Balabina

et al. 2023

Arhivʺ vnutrennej mediciny

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Currently, type 2 myocardial infarction is a rather significant problem, both in terms of diagnosis and treatment. Myocardial infarction without obstructive coronary artery damage occurs in 5-10 % of patients with a myocardial infarction. Optimal strategies for the diagnosis and treatment of patients with myocardial damage associated with non-thrombotic mechanisms have not yet been determined. The article describes a clinical observation of type 2 myocardial infarction on the background of vasospasm, as well as diagnostic and therapeutic tactics in this clinical situation. The main provisions: the patient was 22 years old in the cardiology department due to the pain syndrome behind the sternum for the first time in his life and an increase in body temperature to 37.5 C. From anamnesis: active bodybuilding, taking testosterone in injectable form. The electrocardiogram revealed changes in the type of transmural myocardial ischemia without the dynamics characteristic of myocardial infarction. Troponin I (quantitative test) — 2.1 ng/ml at laboratory reference values of 0.010-0.023 ng/ml. A diagnostic search was conducted for myocardial infarction and acute pericarditis. For the purpose of differential diagnosis, coronary angiography was performed, during which dynamic stenosis of the posterior descending artery was revealed. The decision to stent the vessel was not made. Echocardiography revealed areas of local contractility disorders. The data of the examination showed in favor of myocardial infarction without coronary artery obstruction (type 2). Taking into account the absence of occlusive-stenotic lesions of the coronary arteries, the presence of vasospasm, 1 platelet aggregation inhibitor, medium-dose statins, isosorbide dinitrate, calcium channel blocker, angiotensin-converting enzyme inhibitor was prescribed. Conclusion. Invasive tactics made it more likely to diagnose type 2 myocardial infarction and prescribe the most optimal drug therapy.

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Myeloid-related protein 8/14 and high-sensitivity cardiac troponin I to differentiate type 2 myocardial infarction

Cited by 8 publications

References 10 publications

Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction

Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction

From multi-omics approaches to personalized medicine in myocardial infarction

Type 2 Myocardial Infarction on the Background of Coronary Vasospasm and Invasive Tactics of Its Diagnosis and Treatment

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