Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction

Abstract

Inflammation is a hallmark of the period after a myocardial infarction (MI) that is either promoted or resolved by distinct subtypes of circulating inflammatory cells. The three main monocyte subpopulations play different roles inflammation. This study examined whether the type of MI (type 1 or type 2) or the extent of myocardial injury is associated with differences in monocyte subpopulations. For this purpose, peripheral whole blood from patients with a suspected MI was used for flow cytometric measurements of the monocyte subpopulations, and myocardial injury was classified by cardiac troponin levels in serum. In patients with acute coronary syndrome (n = 82, 62.2% male) similar proportions of the monocyte subsets were associated with the two types of MI, whereas total monocyte counts were increased in patients with substantial myocardial injury vs. those with minor injury (p = 0.045). This was accompanied by a higher proportion of intermediate (p = 0.045) and classical monocytes (p = 0.059); no difference was found for non-classical monocytes (p = 0.772). In patients with chronic coronary syndrome (n = 144, 66.5% male), an independent association with myocardial injury was also observed for classical monocytes (p = 0.01) and intermediate monocytes (p = 0.08). In conclusion, changes in monocyte subpopulation counts, particularly for classical and intermediate monocytes, were related to the extent of myocardial injury in acute and stable coronary artery disease but not to the type of MI.

Repair of the Infarcted Heart: Cellular Effectors, Molecular Mechanisms and Therapeutic Opportunities

“…299,300 In human populations, high numbers of classical or intermediate monocytes associated with future cardiovascular events predict adverse outcomes after MI. [301][302][303] In vivo time-lapse imaging in mice suggests that monocytes rolling in coronary venules are the first to infiltrate the infarct within 30 minutes post-MI, preceding neutrophil invasion which, however, dominates cell infiltration within the first 24 hours post-MI quantitatively. 244 Subsequently, monocytes are mobilized from the splenic reservoir in an angiotensin II-dependent manner.…”

“…299,300 In human populations, high numbers of classical or intermediate monocytes associated with future cardiovascular events predict adverse outcomes after MI. 301–303…”

Dissecting and Visualizing the Functional Diversity of Cardiac Macrophages

“…124 In the context of heart disease and MI, intermediate monocytes (and classical monocytes) are independent markers for myocardial damage and plaque rupture. 125,126 They also are involved in the clearance of cellular debris, similar to classical monocytes, after myocardial ischemia. 127 Although intermediate monocytes have low relative abundance in the monocyte pool (≈5%), 128 they accumulate in the diseased human heart and express numerous inflammatory mediators.…”

Identificação de Potenciais Biomarcadores Cruciais em IAMCSST por Meio de Análise Bioinformática Integrada

“…Felizmente, estudos anteriores demonstraram que os dados do sangue periférico também têm boa fiabilidade. 44,45 Finalmente, embora numerosos estudos apoiassem a potencialidade dos potenciais biomarcadores previstos neste estudo, os resultados das curvas ROC não conseguiram encontrar um gene com elevada confiança (AUC > 90%), e são necessários ensaios consideráveis para validar a sensibilidade e especificidade de potenciais biomarcadores. No entanto, este estudo determinou os potenciais biomarcadores e investigou os mecanismos complexos do IAMCSST desenvolvidos a partir da DACE, o que promoveu a designação do nosso próximo plano para explorar os mecanismos no ensaio clínico em breve.…”