Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease

Wright, Adam; Newby, Chris; Hartley, Ruth; Mistry, Vijay; Gupta, Sumit; Berair, Rachid; Roach, Katy M.; Saunders, Ruth; Thornton, Tracy; Shelley, Maria; Edwards, Karen; Barker, Bethan; Brightling, Christopher E.

doi:10.1111/all.13061

Cited by 14 publications

(16 citation statements)

References 44 publications

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“…Biopsy specimens were embedded in glycol methacrylate and 2-μm sections stained with hematoxylin and eosin and antieosinophil major basic protein (Clone BMK-13, Monosan, Uden, The Netherlands) as previously detailed. E7 Eosinophils were expressed as cells/mm 2 of lamina propria and as cells/mm 2 of epithelium.…”

Section: Methodsmentioning

confidence: 99%

In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

Farahi

Loutsios

Tregay

et al. 2018

Journal of Allergy and Clinical Immunology

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Section: Methodsmentioning

confidence: 99%

In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

Farahi

Loutsios

Tregay

et al. 2018

Journal of Allergy and Clinical Immunology

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“…Patients with COPD have elevated levels of circulating-lineage HLA-DR − CD33 + CD11b + MDSCs [ 25 ]. It was recently reported that collagen type 1 + CD45 dim CD34 − CD14 − CD15 + MDSC-like fibrocytes are increased in the lungs and peripheral blood of COPD patients compared to control subjects [ 26 ]. The intensity of collagen type 1 staining, which marks MDSC-like fibrocytes, was positively associated with lung function; these cells appeared to play a role in air trapping, predominately in the upper lobes.…”

Section: Main Textmentioning

confidence: 99%

Myeloid-derived suppressor cells in non-neoplastic inflamed organs

2018

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BackgroundMyeloid-derived suppressor cells (MDSCs) are a highly heterogeneous population of immature myeloid cells with immunosuppressive function. Although their function in tumor-bearing conditions is well studied, less is known about the role of MDSCs in various organs under non-neoplastic inflammatory conditions.Main bodyMDSCs are divided into two subpopulations, G-MDSCs and M-MDSCs, and their distribution varies between organs. MDSCs negatively control inflammation in inflamed organs such as the lungs, joints, liver, kidneys, intestines, central nervous system (CNS), and eyes by suppressing T cells and myeloid cells. MDSCs also regulate fibrosis in the lungs, liver, and kidneys and help repair CNS injuries. MDSCs in organs are plastic and can differentiate into osteoclasts and tolerogenic dendritic cells according to the microenvironment under non-neoplastic inflammatory conditions.ConclusionThis article summarizes recent findings about MDSCs under inflammatory conditions, especially with respect to their function and differentiation in specific organs.

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“…Fibrocytes are fibroblast-like cells produced by the bone marrow stroma and released in the peripheral circulation [11]. Circulating fibrocytes, defined as CD45 + collagen I + cells, are increased in COPD patients only during an exacerbation and not in a stable state, compared with those in control subjects [12,13]. A high blood fibrocyte concentration during an exacerbation is associated with an increased risk of death [12], suggesting a deleterious role of fibrocytes in COPD evolution.…”

Section: Introductionmentioning

confidence: 99%

“…A high blood fibrocyte concentration during an exacerbation is associated with an increased risk of death [12], suggesting a deleterious role of fibrocytes in COPD evolution. In contrast, myeloid-derived suppressor cell-like fibrocytes, a subpopulation of circulating fibrocytes, are increased in the blood of stable COPD patients and these cells might play a protective role [13]. The presence and role of fibrocytes in the lungs of COPD patients remains controversial and needs to be clarified [13].…”

Section: Introductionmentioning

confidence: 99%

Fibrocyte accumulation in the airway walls of COPD patients

et al. 2019

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The remodelling mechanism and cellular players causing persistent airflow limitation in COPD remain largely elusive. We have recently demonstrated that circulating fibrocytes, a rare population of fibroblast-like cells produced by the bone marrow stroma, are increased in COPD patients during an exacerbation. We aimed to quantify fibrocyte density in situ in bronchial specimens from both control subjects and COPD patients, to define associations with relevant clinical, functional and computed tomography (CT) parameters, and to investigate the effect of the epithelial microenvironment on fibrocyte survival in vitro (“Fibrochir” study).A total of 17 COPD patients and 25 control subjects, all requiring thoracic surgery, were recruited. Using co-immunostaining and image analysis, we identified CD45+ FSP1+ cells as tissue fibrocytes, and quantified their density in distal and proximal bronchial specimens. Fibrocytes, cultured from the blood samples of six COPD patients, were exposed to primary bronchial epithelial cell secretions from control subjects or COPD patients.We demonstrate that fibrocytes are increased in both distal and proximal tissue specimens of COPD patients. The density of fibrocytes is negatively correlated with lung function parameters and positively correlated with bronchial wall thickness as assessed by CT scan. A high density of distal bronchial fibrocytes predicts the presence of COPD with a sensitivity of 83% and a specificity of 70%. Exposure of fibrocytes to COPD epithelial cell supernatant favours cell survival.Our results thus demonstrate an increased density of fibrocytes within the bronchi of COPD patients, which may be promoted by epithelial-derived survival-mediating factors.

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Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease

Cited by 14 publications

References 44 publications

In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

Myeloid-derived suppressor cells in non-neoplastic inflamed organs

Fibrocyte accumulation in the airway walls of COPD patients

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