In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

Farahi, Neda; Loutsios, Chrystalla; Tregay, Nicola; Wright, Adam; Berair, Rachid; Lok, Laurence S.C.; Gillett, Daniel; Cullum, Ian; Simmonds, Rosalind; Summers, Charlotte; Wong, Hiu Yi; Solanki, Chandra K.; Buscombe, J. R.; Pang, Pee Hwee; Thavakumar, Arthikkaa; Peters, A. M.; Brightling, Christopher E.; Condliffe, Alison M.; Chilvers, Edwin R.

doi:10.1016/j.jaci.2018.07.011

Cited by 34 publications

(24 citation statements)

References 12 publications

(21 reference statements)

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“…Farahi et al. reported that more eosinophils were recruited to the lungs of obese patients with asthma compared with non‐obese patients with asthma 45 . Furthermore, eosinophils isolated from asthmatic obese patients had increased chemotaxis and adhesion activity after being stimulated by eotaxin or platelet‐activating factor, compared to eosinophils isolated from asthmatic non‐obese patients or non‐asthmatic non‐obese individuals 46 .…”

Section: The Role Of Eosinophils In Obese Patients With Asthmamentioning

confidence: 99%

“…Loss of M 2 function, either through down‐regulation 53,54 or acute blockade with a selective antagonist 50,55 increases acetylcholine release and causes airway hyperresponsiveness 51,53,54 . Therefore, increased eosinophil recruitment to the lungs, as seen with obesity, 45 may complicate preexisting allergic asthma by enhancing eosinophil recruitment to airways and nerves. For Th2 low obese asthmatic patients, obesity may cause airway hyperresponsiveness through an eosinophil‐independent mechanism 2,56,57 .…”

Section: The Role Of Eosinophils In Obese Patients With Asthmamentioning

confidence: 99%

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Unraveling the connection between eosinophils and obesity

Calco

Fryer

Nie

2020

Journal of Leukocyte Biology

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Obesity affects more than 650 million adults worldwide and is a major risk factor for a variety of serious comorbidities. The prevalence of obesity has tripled in the past forty years and continues to rise. Eosinophils have recently been implicated in providing a protective role against obesity. Decreasing eosinophils exacerbates weight gain and contributes to glucose intolerance in high fat diet‐induced obese animals, while increasing eosinophils prevents high‐fat diet‐induced adipose tissue and body weight gain. Human studies, however, do not support a protective role for eosinophils in obesity. More recent animal studies have also reported conflicting results. Considering these contradictory findings, the relationship between eosinophils and obesity may not be unidirectional. In this mini‐review, we summarize a recent debate regarding the role of adipose tissue eosinophils in metabolic disorders, and discuss local and systemic effects of eosinophils in obesity. Given that adipose eosinophils play a role in tissue homeostasis, more research is needed to understand the primary function of adipose tissue eosinophils in their microenvironment. Therapeutic interventions that target eosinophils in adipose tissue may have the potential to reduce inflammation and body fat, while improving metabolic dysfunction in obese patients.

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Section: The Role Of Eosinophils In Obese Patients With Asthmamentioning

confidence: 99%

Section: The Role Of Eosinophils In Obese Patients With Asthmamentioning

confidence: 99%

Unraveling the connection between eosinophils and obesity

Calco

Fryer

Nie

2020

Journal of Leukocyte Biology

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“…21 Ayrıca Farahi ve ark., astım hastası olan obez kişilerin akciğerlerine eozinofilik inflamasyon belirteci olarak daha fazla eozinofil göçünün olduğunu ifade etmiştir. 22 Artan miyeloid hücre sayısının tersine, yüksek yağlı diyet ile indüklenen obezite modelinde, kemik iliğinde lenfosit gelişiminin önemli bir uyarıcısı olan IL7 baskılanmakta ve lenfoid hücre sayısı anlamlı ölçüde düşmektedir. 23 Bu yüzden inflamasyon potansiyeli artarken, enfeksiyonlara karşı yanıt azalmaktadır.…”

Section: Obezi̇teni̇n Doğuştan İmmün Si̇stem Ve Enfeksi̇yon Duyarliliği üunclassified

Is Obesity a Risk Factor in COVID-19 Pandemic?

Gülbaran¹,

Pehlivan²

2020

Turkiye Klinikleri J Health Sci

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Obezite, harcanan enerjiden daha fazlasının uzun süreli olarak vücuda alınmasından kaynaklanan ve bu enerji rezervlerinin yağ deposu olarak depolanması nedeni ile vücut ağırlığındaki aşırı artış olarak tanımlanmaktadır. 1 Genetik, hormonal, metabolik ve davranışsal bileşenleri içeren ve kronik bir hastalık olarak kabul görülen obezitenin, özellikle geliş-miş ülkelerde prevalansı giderek artmaktadır. 2,3 Dünya Sağlık Örgütü, dünya genelinde toplam 650 milyon insanın obez [beden kitle indeksi ((BKİ)>30 kg/m 2 ] ve 1,9 milyar insanın ise aşırı kilolu (BKİ>27 kg/m 2) olduğunu tahmin etmektedir. 4 Günümüzde küreselleşme, özellikle işlenmiş ve fast-food gıdaların tüketimindeki artışlar sebebiyle diyet ve yaşam

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“…Interestingly, bronchial tissue eosinophils are increased in obesity in spite of a lack of sputum eosinophils [17]. An explanation for this apparent paradox has begun to be revealed by human in vivo tracking of eosinophils [18].…”

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confidence: 99%