Myelofibrosis Presenting as Hypermetabolic Bone Disease by Radionuciide Imaging in a Patient with Asplenia

Unusual Manifestations of Myelofibrosis in a Patient with Congenital Asplenia

“…Of interest, the same findings have been reported in a patient with myelofibrosis and asplenia previously [4]. The uptake pattern is most probably explained by the hypervascularity of bones observed in myelofibrosis, especially in the absence of a spleen.…”

“…To the best of our knowledge, such an association was reported in only 1 other patient [4]. We suggest that this combination was not coincidental but rather interrelated.…”

Metastatic superscan on 99m Tc-MDP bone scintigraphy in a case of carcinoma colon: Common finding but rare etiology

“…[1234] Hematological conditions like leukemia, lymphoma, myelofibrosis, Waldenstrom's macroglobulinemia have been reported to be associated with a superscan. [56] It can also be seen in metabolic bone diseases like renal osteodystrophy, Paget's disease and hyperparathyroidism. [7] Occasionally superscan is seen in hyperthyroidism[8] and fibrous dysplasia.…”

Altered Biodistribution of Radiopharmaceuticals Used in Bone Scintigraphy

“…12 Superscan Due to Metastatic Disease Superscans due to widespread osseous metastases occur most frequently in the context of breast 17,37 and prostate cancer 11,19,38,39 but may also be seen in lung, 11 genitourinary tract, 40 gastrointestinal (GI) tract, 41,42 head and neck, 43 and occasionally hematological malignancies. 16,18,[44][45][46][47] Not surprisingly, metastatic superscans are indicators of poor prognosis. [48][49][50][51] The appearance of a metastatic superscan is characterized by abnormally increased skeletal uptake in a distribution similar to that of the bone marrow, that is, the axial and proximal appendicular skeleton to a greater degree than the appendicular skeleton.…”