Metastatic superscan on ^99m Tc-MDP bone scintigraphy in a case of carcinoma colon: Common finding but rare etiology

Abstract

Bone scintigraphy in which there is excessive skeletal radioisotope uptake in relation to soft tissues along with absent or faint activity in the genitourinary tract is known as a ‘superscan’. Prostate cancer is the most common malignancy associated with superscan along with others such as lung cancer, breast cancer and haematological malignancies. Here we present the case of a 41 year old woman with carcinoma colon with metastatic superscan on 99mTc-MDP bone scintigraphy, a very rare cause for metastatic superscan.

Metastatic superscan on 99m Tc-methylene diphosphonate bone scintigraphy in pediatric neuroblastoma

“…[ 1 ] Common causes include prostate cancer, breast cancer, and lung cancer. [ 2 ] Hematological conditions like leukemia, lymphoma, myelofibrosis, Waldenstrom's macroglobulinemia are sometimes associated with metastatic superscan. Metabolic bone diseases such as renal osteodystrophy, Paget's disease and hyperparathyroidism are also reported as the rare causes of superscan.…”

“…Some of the other rare causes for metastatic superscan include urinary tract transitional cell carcinoma and nasopharyngeal carcinoma. [ 2 3 4 ] However, association of pediatric solid tumor malignancy with metastatic superscan has not been reported previously. We here describe two such cases of neuroblastoma (NB) who presented with metastatic superscan on 99m Tc-methylene diphosphonate (MDP) BS.…”

“…The patient prognosis is usually poor. [ 2 ] Though extremely rare superscan can be associated with pediatric solid tumor malignancies and should be kept in mind while reporting such cases.…”