Metastatic superscan on <sup>99m</sup> Tc-methylene diphosphonate bone scintigraphy in pediatric neuroblastoma

Arora, Saurabh; Dhull, Varun Singh; Mukherjee, Anirban; Tulsyan, Shruti; Behera, Abhishek; Tripathi, Madhavi

doi:10.4103/0972-3919.158552

Cited by 3 publications

(1 citation statement)

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“…In 34 case reports, malignancy was the cause of the superscan, and prostate cancer ( n = 15) was the most common cause, followed by gastric cancer ( n = 10). Other less common cancers that caused superscans included metastatic pheochromocytoma (Tan et al, 2015), paediatric neuroblastoma (Tripathi et al, 2015), intracranial glioma (Shinya et al, 2007), multiple myeloma (Anscombe & Walkden, 1983) and angiogenic myeloid metaplasia (Pour et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Frequency of superscan on bone scintigraphy: A systematic review

Kovacsne

Kozon

Bentestuen

2023

Clin Physio Funct Imaging

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Introduction Bone scintigraphy (BS) is an important tool for detecting bone metastasis. BS with diffuse increased skeletal radioisotope uptake with absent or faint urinary tract and soft tissue activity is defined as a superscan. In this review, we investigate the different etiologies causing superscan and the reported frequency of superscan among different disease entities. Materials and Methods The search terms were ‘bone’ AND ‘superscan’ OR ‘superscan’ in the PubMed database from 1980 to November 2020. Eligibility criteria included the following: Peer‐reviewed studies containing original data using 99mTc‐phosphate‐analogue BS reporting a superscan pattern. Unretrievable papers, imaging modalities other than BS or with insufficient information to assess the aetiology were excluded. The abstracts of every paper and full texts of potentially eligible papers were assessed independently by three observers. Results Sixty‐seven papers were included (48 case reports and 19 cohort studies). Studies conducted in patients with osteomalacia or skeletal fluorosis revealed superscan in all patients. Other benign causes of superscan were hyperparathyroidism and kidney disease. Among papers with malignant cause, prostate cancer was the most common cause, followed by gastric cancer. The frequency of superscans ranged from 1.3% in a cohort of mixed cancer types up to 2.6% in patients with gastric cancer and up to 23% in a cohort of prostate cancer patients. Conclusion Superscan is most frequently seen in prostate cancer, but numerous other cancers and metabolic bone diseases can cause superscan, which should be kept in mind when encountering an unexpected superscan on BS.

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Section: Resultsmentioning

confidence: 99%

Frequency of superscan on bone scintigraphy: A systematic review

Kovacsne

Kozon

Bentestuen

2023

Clin Physio Funct Imaging

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Superscan Pattern on Bone Scintigraphy: A Comprehensive Review

Askari,

Shakeri,

Roustaei

et al. 2024

Diagnostics

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Background/Objectives: The superscan pattern is a characteristic finding on bone scintigraphy, associated with a variety of metabolic bone diseases, malignancies, and other conditions. This pattern is characterized by a diffuse and intense uptake of radiotracer throughout the entire skeleton. Despite being a relatively rare finding, the superscan pattern can have significant clinical implications. Methods: This comprehensive review summarizes the available literature on the superscan pattern, focusing on its pathophysiology, clinical significance, and differential diagnoses. Relevant studies and case reports were analyzed to outline the diagnostic challenges associated with the interpretation of bone scintigraphy featuring the superscan pattern. Results: The literature highlights the clinical significance of the superscan pattern in various metabolic and oncologic conditions. Misinterpretation of this pattern can lead to diagnostic challenges, especially in distinguishing it from other pathologic conditions. Differential diagnosis remains crucial in the accurate interpretation and subsequent management of patients with this finding. Conclusions: This review provides a comprehensive overview of the superscan pattern on bone scintigraphy, aiming to assist clinicians in recognizing and managing this rare yet clinically important finding.

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