Myelofibrosis in neuroblastoma

Abstract

Myelofibrosis, a rare childhood disorder, has been reported as an associated complication of certain hematologic malignancies or as an isolated idiopathic process. In this report, we describe a patient with metastatic neuroblastoma whose initial presentation included the findings of myelofibrosis and leukoerythroblastosis. The myelofibrosis regressed with chemotherapy and did not recur when the patient's tumor reappeared.

Transient myelofibrosis with autoimmune pancytopenia: a case report

“…Many cases of myelofibrosis are idiopathic or associated with some malignant diseases such as MDS, bone marrow invasion of cancer cells, or leukemic infiltration [1,4,5,10,16,18,19,21]. We report here an infant case of this benign myelofibrosis with autoimmune pancytopenia.…”

Secondary Myelofibrosis in Children

“…This is also supported by improvement of MF in children with the treatment of vitamin D deficiency rickets 10,13 and neuroblastoma. 5 In children not responding to treatment of underlying condition, a trial of steroids may be worthwhile.…”

“…19 There are few (34) case reports of myelofibrosis in children reported in English literature (Table 2). [3][4][5][6][7][8][9][10][11][12][13]17,20 Most of these are isolated case reports. The largest series 3 of 23 children with ALL, treated with appropriate chemotherapy, are showing that ultimate disease outcome did not depend on MF.…”

Sudden death due to adrenal neuroblastoma: child abuse mimic?

“…The blood count abnormalities can manifest as anemia, acute lymphocytic leukemia-like symptoms, or cutaneously as hemorrhagic petechiae. Furthermore, the bone metastases can cause bone pain, which in young children who cannot verbally communicate the pain, may manifest as limping or irritability [12].…”