1995
DOI: 10.1002/jemt.1070320303
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Myelin mutants: New models and new observations

Abstract: The myelin mutants have been extensively used as tools to study the complex process of myelination in the central and peripheral nervous system. A multidisciplinary approach to the study of these models ultimately allows a correlation to be made between phenotype and genotype. This correlation may then lead to the formation of new hypotheses about the functions of the products of genes involved in myelination. This review presents a number of new myelin mutants which have recently been described. The species i… Show more

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Cited by 39 publications
(29 citation statements)
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References 102 publications
(143 reference statements)
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“…Ultrastructural observations on myelin mutants show that in the CNS, the integral proteolipid protein (PLP) may be involved with intermembrane interactions at the extracellular surfaces and that MBP is responsible for interactions at the cytoplasmic surfaces (or major dense line; reviewed by Lunn et al, 1995;Griffiths, 1996). Most of the studies carried out with MBP demonstrate its ability to bind to specific lipids and detergents (see above).…”
Section: Lipid-bound Mbp Promotes/stabilizes Formation Of Myelin-likementioning
confidence: 95%
“…Ultrastructural observations on myelin mutants show that in the CNS, the integral proteolipid protein (PLP) may be involved with intermembrane interactions at the extracellular surfaces and that MBP is responsible for interactions at the cytoplasmic surfaces (or major dense line; reviewed by Lunn et al, 1995;Griffiths, 1996). Most of the studies carried out with MBP demonstrate its ability to bind to specific lipids and detergents (see above).…”
Section: Lipid-bound Mbp Promotes/stabilizes Formation Of Myelin-likementioning
confidence: 95%
“…Olig1-null mice develop severe neurological abnormalities, such as abnormal limb clasping, generalized tremors, ataxia, and tonic seizures (Fig. 1C), which are characteristic features of myelindeficient animals in which oligodendrocyte differentiation occurs normally but the synthesis of myelin sheaths is disrupted to varying degrees (Nave, 1994;Lunn et al, 1995;Gow et al, 1998).…”
Section: Olig1-null Mice Exhibit Severe Neurological Abnormalitiesmentioning
confidence: 99%
“…The myelin disorder that characterizes this mutant is probably due to a defect in oligodendrocytes [Duncan et al, 1992;Lunn et al, 1995;Couve et al, 1997], leading to a disruption in the development and maintenance of central, but not peripheral, myelin. Cross-breeding experiments indicate that taiep rats are affected by an autosomal recessive mutation [Holmgren et al, 1989].…”
Section: Introductionmentioning
confidence: 99%