Mycotoxin levels in the digestive tissues of immature gilts exposed to zearalenone and deoxynivalenol

Gajęcka, Magdalena; Waśkiewicz, Agnieszka; Zielonka, Łukasz; Goliński, Piotr; Rykaczewska, Anna; Lisieska-Żołnierczyk, Sylwia

doi:10.1016/j.toxicon.2018.08.002

Cited by 16 publications

(16 citation statements)

References 68 publications

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“…The gastrointestinal tract is often an important target for first exposure to these dietary toxins [ 30 , 31 ]. It is reported that FB1 can affect the health of the gastrointestinal tract (GIT) in animals [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells

Jia

Liu

et al. 2020

IJMS

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Fumonisin contaminates food and feed extensively throughout the world, causing chronic and acute toxicity in human and animals. Currently, studies on the toxicology of fumonisins mainly focus on fumonisin B1 (FB1). Considering that FB1, fumonisin B2 (FB2) and fumonisin B3 (FB3) could coexist in food and feed, a study regarding a single toxin, FB1, may not completely reflect the toxicity of fumonisin. The gastrointestinal tract is usually exposed to these dietary toxins. In our study, the human gastric epithelial cell line (GES-1) was used as in vitro model to evaluate the toxicity of fumonisin. Firstly, we found that they could cause a decrease in cell viability, and increase in membrane leakage, cell death and the induction of expression of markers for endoplasmic reticulum (ER) stress. Their toxicity potency rank is FB1 > FB2 >> FB3. The results also showed that the synergistic effect appeared in the combinations of FB1 + FB2 and FB1 + FB3. Nevertheless, the combinations of FB2 + FB3 and FB1 + FB2 + FB3 showed a synergistic effect at low concentration and an antagonistic effect at high concentration. We also found that myriocin (ISP-1) could alleviate the cytotoxicity induced by fumonisin in GES-1 cells. Finally, this study may help to determine or optimize the legal limits and risk assessment method of mycotoxins in food and feed and provide a potential method to block the fumonisin toxicity.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells

Jia

Liu

et al. 2020

IJMS

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“…It was supposed that ZEA can be excreted very fast by urine with low residue in tissue ( Obremski et al., 2003 ). However, several studies indicated that low ZEA residue could be accumulated in the gastrointestinal tissue and liver of gilts after weeks of exposure to a low dose of ZEA in diets ( Gajecka et al., 2018 ; Zielonka et al., 2015 ). ZEA and its metabolites are predominantly excreted via the fecal route in the form of glucuronides due to an extensive biliary excretion.…”

Section: Discussionmentioning

confidence: 99%

Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows

Zhou

Lei

et al. 2020

Animal Nutrition

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This study was conducted to evaluate the alleviation of Bacillus subtilis ANSB01G culture as zearalenone (ZEA) biodegradation agent on oxidative stress, cell apoptosis and fecal ZEA residue in the first parity gestation sows during the gestation. A total of 80 first-parity gilts (Yorkshire × Landrace) were randomly allocated to 4 dietary treatments with 20 replications per treatment and one gilt per replicate. The dietary treatments were as follows: CO (positive control); MO (negative control, ZEA level at 246 μg/kg diet); COA (CO + B. subtilis ANSB01G culture with 2 × 10 9 CFU/kg diet); MOA (MO + ZEA level at 260 μg/kg diet + B. subtilis ANSB01G culture with 2 × 10 9 CFU/kg diet). The experiment lasted for the whole gestation period of sows. Results showed that feeding the diet naturally contaminated with low-dose ZEA caused an increase of cell apoptosis in organ and the residual ZEA in feces as well as a decrease of antioxidant function in serum. The addition of B. subtilis ANSB01G culture in the diets can effectively alleviate the status of oxidative stress and cell apoptosis induced by ZEA in diets of gestation sows, as well as decrease the content of residual ZEA in feces.

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“…These secondary metabolites of fungi affect global agriculture so prolifically that they are virtually ubiquitous at a certain concentration in the human daily diet [11]. Mycotoxins are able to prevent degradation or degradation by juices and digestive enzymes present in the digestive tract of mammals [12]. These compounds also show stability in the digestive tract of ruminant farm animals, which allows mycotoxins to persist in meat and dairy products [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Mycotoxins are able to prevent degradation or degradation by juices and digestive enzymes present in the digestive tract of mammals [12]. These compounds also show stability in the digestive tract of ruminant farm animals, which allows mycotoxins to persist in meat and dairy products [12,13]. Moreover, thermal treatment such as cooking or freezing also does not break down some mycotoxins [14].…”

Section: Introductionmentioning

confidence: 99%

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Association Between Mycotoxin Exposure and Dietary Habits in Colorectal Cancer Development Among a Polish Population: A Study Protocol

Przybyłowicz

Arłukowicz

Danielewicz

et al. 2020

IJERPH

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Colorectal cancer (CRC) is one of the most common and lethal types of cancer worldwide. The developing of this disease includes many factors such as genetic, socioeconomic, environmental, and lifestyle factors, and nutrition habits. The aim of the study is the determination of zearalenone and its metabolite level in the biological samples of participants at risk of CRC, in relation to the nutrition data and information on the quality of life dependent on health. In the cohort clinical trial, 150 participants aged between 50 and 65 will be studied. The participants will be assigned into two groups depending on the colonoscopy result. Participants will be tested at dietary intake, quality of life, sleep time and quality, stress level as well as biochemical parameters of the blood. Moreover, in the biological samples, concentration of zearalenone and its metabolites (α-zearalenol and β-zearalenol) as well as the characteristics of gastrointestinal bacterial will be determined, and the end of the trial for both groups and their results will be compared. Taking into account the possible effect of mycotoxins and nutrition habits on the development of cancer, the results obtained may allow the formulation of new nutritional recommendations and reduce the development and occurrence of CRC.

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Mycotoxin levels in the digestive tissues of immature gilts exposed to zearalenone and deoxynivalenol

Cited by 16 publications

References 68 publications

Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells

Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells

Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows

Association Between Mycotoxin Exposure and Dietary Habits in Colorectal Cancer Development Among a Polish Population: A Study Protocol

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