Mycotoxin exposure assessments in a multi-center European validation study by 24-hour dietary recall and biological fluid sampling

Ruyck, Karl De; Huybrechts, Inge; Yang, Shupeng; Arcella, Davide; Claeys, Liesel; Abbeddou, Souheila; Keyzer, Willem De; Vries, Jeanne de; Ocké, Marga C.; Ruprich, Jiří; Boevre, Marthe De; Saeger, Sarah De

doi:10.1016/j.envint.2020.105539

Cited by 51 publications

(39 citation statements)

References 65 publications

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“…Several authors [173,174] reported working on a molecular imprinted polymers method which can be employed for OTA purification from urine. In 2020 a group of scholars [175] conducted research on mycotoxin exposure assessments in a multi-center European validation study by 24-h dietary recall and biological fluid sampling where they established a positive correlation between the ochratoxin A (and several other mycotoxins) levels, 24 h exposure time and serum. This could help scholars and professionals to identify chronic exposure biomarkers and to easier assess a single-time point exposure.…”

mentioning

confidence: 99%

Mycotoxins—Biomonitoring and Human Exposure

Habschied

Šarić

Krstanović

2021

Toxins

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Mycotoxins are secondary metabolites produced by fungal species that commonly have a toxic effect on human and animal health. Different foodstuff can be contaminated and are considered the major source of human exposure to mycotoxins, but occupational and environmental exposure can also significantly contribute to this problem. This review aims to provide a short overview of the occurrence of toxigenic fungi and regulated mycotoxins in foods and workplaces, following the current literature and data presented in scientific papers. Biomonitoring of mycotoxins in plasma, serum, urine, and blood samples has become a common method for determining the exposure to different mycotoxins. Novel techniques are more and more precise and accurate and are aiming toward the simultaneous determination of multiple mycotoxins in one analysis. Application of liquid chromatography (LC) methodologies, coupled with tandem mass spectrometry (MS/MS) or high-resolution mass spectrometry (HRMS) has become a common and most reliable method for determining the exposure to mycotoxins. Numerous references confirm the importance of mycotoxin biomonitoring to assess the exposure for humans and animals. The objectives of this paper were to review the general approaches to biomonitoring of different mycotoxins and the occurrence of toxigenic fungi and their mycotoxins, using recent literature sources.

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confidence: 99%

Mycotoxins—Biomonitoring and Human Exposure

Habschied

Šarić

Krstanović

2021

Toxins

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“…The mycotoxins showing the highest incidence in the present work were NEO (40%), followed by HT-2 (17.6%) and T-2 (5.8%). The presence of T-2 and HT-2 was also reported in urine samples from France, Belgium, the Czech Republic, Norway, and the Netherlands (29.8% incidence), with a median of 93.5 ng/L and reaching urinary levels up to 39,600 ng/L; NEO showed low incidence (6.4%), reaching median and maximum values of 168 and 3390 ng/L, respectively [25]. Low incidence (2.3%) was reported for T-2 in urine samples from China [37], while HT-2 and T-2 toxins were not detected in urine samples from Brazil [6].…”

Section: Sample Analysesmentioning

confidence: 68%

“…2, HT-2 was the most common mycotoxin in combination present in all the co-occurrent samples, followed by NEO, which was present in two of the three multicontaminated urine samples. Several pilot studies applying multibiomarker methods have shown regional differences in urinary biomarker excretion patterns in Europe, Asia, and Africa [25][26][27][28]. For instance, DON was highly common in urine samples from adult populations in European countries, including Sweden (>90%) [29], Norway (99%) [30], the United Kingdom (93-98.7%) [30,31], Italy (76-87%) [30,32], Spain (68.5-91%) [33,34], and Portugal (63%) [35].…”

Section: Sample Analysesmentioning

confidence: 99%

Biomonitoring of Multiple Mycotoxins in Urine by GC–MS/MS: A Pilot Study on Patients with Esophageal Cancer in Golestan Province, Northeastern Iran

Niknejad

Escrivá

Rad

et al. 2021

Toxins

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A pilot study to investigate the occurrence of 10 mycotoxins (deoxynivalenol, DON; 3-acetyldeoxynivalenol, 3-ADON; 15-acetyldeoxynivalenol, 15-ADON; fusarenon-X, FUS-X; diacetoxyscirpenol, DAS; nivalenol, NIV; neosolaniol, NEO; zearalenone, ZON; zearalanone, ZAN; T-2 toxin, T-2; and HT-2 toxin, HT-2) in esophageal cancer patients was performed with the urinary biomarkers approach in Golestan, Iran. Urine multimycotoxin analysis was performed by dispersive liquid–liquid microextraction and gas chromatography–tandem mass spectrometry (GC–MS/MS) analysis, and values were normalized with urinary creatinine (μg/g). Four mycotoxins, namely NEO (40%), HT-2 (17.6%), DON (10%), and HT-2 (5.8%), were detected in the analyzed urine samples. DON was only detected in the control group (5.09 μg/g creatinine), while T-2 (44.70 μg/g creatinine) was only present in the esophageal cancer group. NEO and HT-2 were quantified in both control and case groups, showing average of positive samples of 9.09 and 10.45 μg/g creatinine for NEO and 16.81 and 29.09 μg/g creatinine for HT-2, respectively. Mycotoxin co-occurrence was observed in three samples as binary (NEO/HT-2 and T-2/HT-2) and ternary (DON/NEO/HT-2) combinations, reaching total concentrations of 44.58, 79.13, and 30.04 µg/g creatinine, respectively. Further investigations are needed to explore a causal association between mycotoxin contamination and esophageal cancer. For this pilot study in Golestan, the low sample size was a very limiting factor.

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“…Biomarkers of exposure (in serum, urine and milk) are useful tools to complete the information about exposure, metabolism, toxicology and the carry-over rates of the different parent compounds or metabolites in the context of human (particularly infant) or animal exposure to mycotoxin hazards (De Ruyck et al, 2020). Due to the long half-life of albumin in humans, the measurement of aflatoxin albumin adducts and their derivatives in blood are strongly preferred, and indicate an exposure extent over 1-2 months (Leong et al, 2012).…”

Section: Group 1 (Carcinogenic To Humans)mentioning

confidence: 99%

Current Status of Mycotoxin Contamination of Food and Feeds and Associated Public Health Risk in Serbia

Milićević¹,

Udovički²,

Petrović³

et al. 2020

Meat Technology

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Mycotoxins are chemical hazards of microbiological origin, produced mainly by filamentous fungi during their secondary metabolism. The role of mycotoxins has been recognized in the aetiology of a number of diseases, particularly cancers that belong to non-communicable diseases (NCDs). The NCDs have a leading and growing contribution to preventable deaths and disability across the globe. The NCDs are known as chronic diseases, tend to be of long duration and are the result of a combination of genetic, physiological, environmental and behavioural factors. Following the increased interest in health effects caused by synergisms between natural and synthetic contaminants along the food chain, mycotoxin contamination will continue to be an area of concern for producers, manufacturers, regulatory agencies, researchers and consumers in the future. Considering that their presence in food depends strongly on climatic conditions, in Serbia, recent drought and then flooding confirmed that mycotoxins are one of the foodborne hazards most susceptible to climate change. In this article, we review key aspects of mycotoxin contamination of the food supply chain and attempt to highlight the latest trends and projections for mycotoxin reduction from a Serbian perspective.

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Mycotoxin exposure assessments in a multi-center European validation study by 24-hour dietary recall and biological fluid sampling

Cited by 51 publications

References 65 publications

Mycotoxins—Biomonitoring and Human Exposure

Mycotoxins—Biomonitoring and Human Exposure

Biomonitoring of Multiple Mycotoxins in Urine by GC–MS/MS: A Pilot Study on Patients with Esophageal Cancer in Golestan Province, Northeastern Iran

Current Status of Mycotoxin Contamination of Food and Feeds and Associated Public Health Risk in Serbia

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