mycotoxin binding to bovine uterine steroid hormone receptors

Blankenship, L.T.; Dickey, J. F.; Bodine, A.B.

doi:10.1016/0093-691x(82)90092-9

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…On the contrary, AFM 1 presented an extent of receptors binding, although in quite higher concentrations. Furthermore, aflatoxicol, another AFB 1 metabolite, showed a small binding ability to oestrogen receptors (Blankenship et al, 1982). In our study, the possible binding of oestrogen receptors by AFB 1 metabolites could have disturbed gonadotrophins secretion and consequently reduced oestrogen production.…”

Section: Discussionmentioning

confidence: 79%

Effect of aflatoxin B1 on blood serum oestradiol-17² and progesterone concentrations during the luteal phase and the synchronized oestrus of goats

et al. 2017

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The effect of prolonged aflatoxin B 1 (AFB 1 ) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the luteal phase and the synchronized oestrus was investigated. Thirty-six Greek indigenous primiparous goats were used, during the oestrus period; 12 goats received, per os, 50 μg (treated group T50) and 12 goats received 100 μg (treated group T100) AFB 1 /day/head, respectively, for approximately 1.5 month, while 12 goats served as controls (C). On day 36 of the experiment, each goat was injected, i.m, 0.5 ml prostaglandin F 2α (PGF 2α ). Blood samples were collected from each goat twice a week, before PGF 2α injection, as well as every 4 hours from the onset to the end of the synchronized oestrus. Oestradiol-17β and progesterone concentrations in blood serum were determined using radioimmunoassay. During the whole luteal(s) phase(s), linear regression analysis revealed a significant negative dependence (P < 0.05) of oestradiol-17β and a significant positive dependence (P < 0.05) of progesterone over group (C = 0, T50 = 50, T100 = 100), in a dose dependent manner. During the synchronized oestrus, multiple linear regression analysis revealed a significant negative dependence (P < 0.05) of oestradiol-17β, as well as a significant positive dependence (P < 0.05) of progesterone over group (C = 0, T50 = 50, T100 = 100) and over time (hours, from the onset to the end of the synchronized oestrus). No significant differences were noticed among the three groups, regarding the body weight of the goats from the onset to the end of AFB 1 administration, the occurrence or the duration of the synchronized oestrus presented by the goats (P > 0.05).In conclusion, prolonged AFB 1 administration at doses of 100 or even of 50 μg/day/head changes the hormonal pattern in blood during the luteal phase and the synchronized oestrus of goats, being in oestrus period.

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Section: Discussionmentioning

confidence: 79%

Effect of aflatoxin B1 on blood serum oestradiol-17² and progesterone concentrations during the luteal phase and the synchronized oestrus of goats

et al. 2017

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“…Kyrein (1974) observed that aflatoxins B 1 , G 1, and G 2 did not present any binding affinity to oestrogen receptors derived from healthy uterus of calves, although aflatoxin M 1 presented a small extent of receptors binding, but in quite higher concentrations compared with oestradiol-17β. Moreover, no binding affinity was observed for AFB 1 or aflatoxin M 1 to oestrogen or progesterone receptors of cow uterus (Blankenship et al 1982), while aflatoxicol showed a small binding affinity, but only to oestrogen receptors.…”

Section: Discussionmentioning

confidence: 97%

Effect of prolonged aflatoxin B<sub>1</sub> administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --

Kourousekos

Theodosiadou

Lymberopoulos

et al. 2015

Czech J. Anim. Sci.

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ABSTRACT:The effect of prolonged aflatoxin B 1 (AFB 1 ) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the anoestrus period was investigated. Thirty Greek indigenous goats were used; 10 goats received, per os, 50 μg (treated group T50) and 10 goats received 100 μg (treated group T100) AFB 1 /day/head, respectively, for 31 days, while 10 goats served as controls (C). Blood samples were collected from each goat twice a week to determine serum oestradiol-17β and progesterone concentrations by radioimmunoassay. Multiple linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum oestradiol-17β concentration over group (C = 0, T50 = 50, T100 = 100), in a dosedependent manner, and a significant (P < 0.05) negative dependence over time (0-31 days, from the onset to the end of AFB 1 administration). Linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum progesterone concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner. Pearson's correlation coefficient revealed a significant (P < 0.05) positive correlation between blood serum oestradiol-17β and progesterone concentration, but only in the goats of the control group. In conclusion, the prolonged administration of 100 or even of 50 μg AFB 1 /day/head during the anoestrus period, increased blood serum oestradiol-17β and progesterone concentrations of goats, in a dose-dependent manner, and in the treated groups disturbed the positive correlation between oestradiol-17β and progesterone concentration shown in the goats of the control group.

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“…Interestingly, an isolated paper reported that aflatoxicol may bind to bovine uterine estrogen receptors in vitro , although its potency is much lower than the strong estrogen-agonist mycotoxin, zearalenone (28): to our best knowledge, the role of aflatoxicol as endocrine disrupter in the disorders of reproduction or lactation of cattle has not been further explored, nor any possible significance for consumers safety.…”

Section: Global Aspectsmentioning

confidence: 99%

The Hotspot for (Global) One Health in Primary Food Production: Aflatoxin M1 in Dairy Products

Frazzoli

Gherardi

Saxena

et al. 2017

Front. Public Health

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One Health involves the multifaceted environment-animal-human web: nevertheless, the role of toxicological issues has yet to be fully explored in this context. Aflatoxin B1 (AFB1) contamination of feeds is a risk for the health of several farm animals, including fishes; milk is the only food of animal origin where a significant feed-food carry over may occur. The main AFB1-related compound present in milk is the hydroxy-metabolite aflatoxin M1 (AFM1). Besides contamination of raw milk, AFM1 is of concern for the whole dairy chain; AFM1 may also contaminate the milk of several other ruminants used for milk/dairy production. In a One Health perspective, milk represents a sentinel matrix for AFB1 vulnerability of the agro-food system, that is crucial in a phase when food/nutritional security becomes a global issue and climatic changes may affect agricultural productions. In the global setting, food chain exposure to long-term toxicants, such as AFM1, is a growing concern for economically developing countries, whereas global trade and climatic change makes AFM1 an emerging hot issue in economically developed countries as well. We critically review the state of the art on AFM1 risk assessment and risk management using two scenarios as case studies: a European Union country where the health system aims at ensuring a high-level protection of food chain (Italy) and the world’s largest (and economically developing) producer of dairy products by volume (India). The case studies are used to provide building blocks for a global One Health framework.

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mycotoxin binding to bovine uterine steroid hormone receptors

Cited by 13 publications

References 18 publications

Effect of aflatoxin B1 on blood serum oestradiol-17² and progesterone concentrations during the luteal phase and the synchronized oestrus of goats

Effect of aflatoxin B1 on blood serum oestradiol-17² and progesterone concentrations during the luteal phase and the synchronized oestrus of goats

Effect of prolonged aflatoxin B<sub>1</sub> administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period --

The Hotspot for (Global) One Health in Primary Food Production: Aflatoxin M1 in Dairy Products

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