Mycotic Endophthalmitis in Drug Abusers

Elliott, James H.; O’Day, Denis M.; Gutow, Gary S.; Podgorski, Steven F.; Akrabawi, Patricia L.

doi:10.1016/0002-9394(79)90757-8

Cited by 59 publications

(10 citation statements)

References 16 publications

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“…However, isolated involvement of the anterior segment without involvement of the posterior pole has been reported. These cases demonstrate the ability of these moulds to gain access to the anterior chamber via the ciliary body and iris vessels [7,13,16,28].…”

Section: Discussionmentioning

confidence: 97%

Histological examination of an eye with endogenous Aspergillus endophthalmitis treated with oral voriconazole: a case report

Aliyeva¹,

Ullmann

Kottler³

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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Endogenous Aspergillus endophthalmitis is a devastating condition often associated with immunodeficiency. The pathogenesis of this entity implies the primary invasion of choroidal and retinal vessels. The lack of antifungal drugs with high blood-ocular permeability results in an extremely poor visual prognosis. Our histological examination indicates promising activity and ocular penetration of the new antifungal agent voriconazole.

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Section: Discussionmentioning

confidence: 97%

Histological examination of an eye with endogenous Aspergillus endophthalmitis treated with oral voriconazole: a case report

Aliyeva¹,

Ullmann

Kottler³

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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“…In the recent literature two methods of treatment have been described: 1) After making the diagnosis on the grounds of the history and the clinical picture, and in some cases with the help of a vitreous biopsy to establish the diagnosis of Candida endophthalmitis, antimycotics are administered systemicaUy only: intravenous amphotericine B in increasing doses up to a maximum of 10mg/kg body weight, in combination with the synergically working 5-fluorocytosine per os (150mg/kg body weight/day) for 2 to 6 weeks, then continuation of the 5-fluorocytosine, sometimes supplemented with the new preparation ketokonazol per os (Stone et al, 1975;Snip and Michels, 1976;Jones, 1978;Aguilar et al, 1979;Elliott et al, 1979;Barthelemy et al, 1981;Clarkson and Green, 1981;Jones et al, 1981). Heroin addicts, however, tend to withdraw from the lengthy treatment before it is completed.…”

Section: Discussionmentioning

confidence: 99%

“…These have been either single cases or small groups (Getnick and Rodrigues, 1974;Stone et al, 1975;Stern et al, 1977;Elliott et al, 1979;Aguilar et al, 1979;Perraut et al, 1981). In the literature there is as yet no concensus of opinion about the best treatment for this condition, which usually occurs as an isolated infection in one eye (Robertson et al, 1974;Jones, 1978;Blumenkranz and Stevens, 1980).…”

Section: Introductionmentioning

confidence: 99%

Candida endophthalmitis in heroin addicts

Hogeweg¹,

Jong

1983

Doc Ophthalmol

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The clinical course of endophthalmitis, presumably due to Candida albicans, in nine eyes of heroin addicts is described. In six of the seven eyes in which pars plana vitrectomy was performed the diagnosis was confirmed by the cultivation of Candida albicans from the rinsing fluid. Both purely intraocular treatment and a combination of local and systemic antimycotic therapy caused the intraocular infection to disappear. In this small group of patients the results were most favourable when treatment was started early.

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“…24,25 Candida typically causes endophthalmitis as a complication of candidemia 26 or as a result of epidemics of contaminated irrigating solutions used in intraocular surgery. Yeast forms, hyphae, and pseudohyphae may all be identified in clinical specimens; their identification is facilitated by staining with KCl 10%.…”

Section: Candidamentioning

confidence: 99%