Mycosis Fungoides with Multiple Oral Mucosal Lesions

Abstract

Mycosis fungoides is a cutaneous T-cell lymphoma which in its later stages affects extracutaneous sites, including the oral mucosa. A case is presented in a 69-year-old male in which oral involvement was widespread and rapidly progressive. Although gingival involvement, as seen in this patient, is relatively rare, it is useful for the periodontist to be aware of the oral manifestations of this disease since cutaneous lesions would most likely be covered if the patient were to present for consultation on an ambulatory basis.

Osteonecrosis of the Jaw in Association With Chemotherapy in the Setting of Cutaneous T-Cell Lymphoma

“…11 In reviewing the literature, a PubMed and Medline search was conducted using the following key words and combined searches: S ezary, T-cell, lymphoma, CTCL, mycosis fungoides, osteonecrosis, and oral. After a review of all the scientific literature in the English language, 23 reported cases of intraoral manifestations of CTCL were found, 6,11,[17][18][19][20][21][22][23][24][25][26][27][28][29] …”

Mycosis fungoides involving the oral cavity

“…Reports of oral cavity involvement are rare, although autopsy series suggest an incidence of up to 13% 1–3 . To the authors’ knowledge, only 34 cases have been reported in the English published literature since the first report in 1914 4–22 . Sirois et al reported the largest series of eight cases representing <1% incidence of oral manifestation in 824 patients with MF over a 25‐year period 4 .…”

“…Sirois et al reported the largest series of eight cases representing <1% incidence of oral manifestation in 824 patients with MF over a 25‐year period 4 . The age in these cases was 36–75 years, with an approximate equal distribution in men and women 4–22 . A history of preceding skin lesions ranging from months to years is typical, with the diagnosis of MF not uncommonly delayed as a result of difficulties in histopathologic interpretation in the early stage when cytologic atypia is minimal 23 …”

“…Oral‐cavity involvement is rare, with only 34 reported cases in the published literature. Involvement of the oral cavity is usually associated with a poor prognosis as a result of systemic disease progression 1–19 . The aim of this case study is to document our experience with a patient diagnosed with oral‐cavity involvement with extracutaneous MF.…”

Oral Involvement in Lymphomatoid Papulosis

“…Oral involvement in MF [21, 22, 23, 24, 25, 26, 27, 28]is an uncommon (less than 1% of cases) feature and usually is associated with poor prognosis. Clinically the oral lesions are manifested as painful ulcers, nodules or erythematous indurated plaques, leukoplakia-like surface involving with descending frequency the tongue, palate, gingival, buccal mucosa, lips and oropharynx.…”