Oral Involvement in Lymphomatoid Papulosis

Abstract

Oral involvement in cutaneous CD30+ T-cell lymphoid proliferations is rare and has received little attention in the dermatologic literature. The authors report 2 patients with self-healing, recurrent papulonodular eruptions with the classic clinical, histopathological and immunophenotypic features of lymphomatoid papulosis, which developed two ulcerated papules and an ulcerative nodule on the dorsum of the tongue, respectively. The lesions appeared coincident with a new cutaneous relapse of the disease. Histopathological and immunophenotypic features were similar to those of the cutaneous lesions. All lesions regressed spontaneously after several weeks. Since then, and after follow-up periods of 3 and 7 years, respectively, no evidence of extracutaneous involvement has been detected. Oral involvement in lymphomatoid papulosis is an uncommon event, probably without prognostic significance. Previously reported cases are reviewed. The differential diagnosis of atypical T-cell lymphoid infiltrates observed in the oral mucosa is discussed.

Solitary oral ulceration as the first appearance of lymphomatoid papulosis: a diagnostic challenge

“…In very rare instances, oral mucosal involvement has been described. [2][3][4][5][6] We report a patient who developed a solitary oral ulceration as the first sign of LyP.…”

“…LyP lesions mainly involve the trunk and the limbs but they may be located at any skin area. In very rare instances, oral mucosal involvement has been described 2–6 . We report a patient who developed a solitary oral ulceration as the first sign of LyP.…”

“…It usually presents with recurrent, self‐healing crops of papules and/or nodules, which sometimes ulcerate. Oral involvement seems to be an unusual clinical appearance and we are only aware of six previous definite cases 2−6 (Table 1). All these patients showed solitary or rarely multiple ulcers, 5–10 mm in diameter, with infiltrated borders, occurring on the tongue and/or oral commissure.…”

CD30‐positive anaplastic large T‐cell lymphoma of the tongue

“…Malignant lymphomas account for 3.5% of all oral malignancies 4 . Only few cases with oral mycosis fungoides 5 and lymphomatoid papulosis 6 were described. These entities were excluded by the absence of previous, concurrent or subsequent characteristic skin lesions in our case.…”