Mycosis fungoides in Patients under 20 Years of Age: Report of 7 Cases, Review of the Literature and Study of the Clinical Course

Quaglino, Pietro; Zaccagna, Alessandro; Verrone, A; Dardano, F.; Bernengo, Maria Grazia

doi:10.1159/000018196

Cited by 68 publications

(60 citation statements)

References 20 publications

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“…In addition, two further patients developed Hodgkin disease. 6,8,9 In the current study, five patients developed progressive disease beyond Stage I. One presented initially with poikiloderma, and had associated lymphomatoid papulosis, one with follicular mucinosis, and three with the classic patches and plaques of MF.…”

Section: Prognosismentioning

confidence: 53%

Outcome in 34 patients with juvenile‐onset mycosis fungoides

Wain

Orchard

Whittaker

et al. 2003

Cancer

136

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New methodology for the stereoselective synthesis of trisubstituted olefins is presented. The use of ortho‐diphenylphosphanyl benzoate (o‐DPPB) as a directing leaving group for copper‐mediated allylic substitution with Grignard reagents allowed for the stereoselective construction of a wide range of E olefins, without the need for an adjacent electron‐withdrawing group. Our modular three‐step approach toward trisubstituted alkenes commenced with geminal α‐methylene aldehydes. Addition of an organometallic reagent and introduction of the o‐DPPB group by esterification was followed by the o‐DPPB‐directed copper‐mediated allylic substitution with a Grignard reagent to furnish stereodefined trisubstituted olefins. Additionally, incorporation of a stereocenter from the chiral pool allowed the preparation of an enantiomerically pure olefin that bore three alkyl substituents in high E/Z selectivity.

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Section: Prognosismentioning

confidence: 53%

Outcome in 34 patients with juvenile‐onset mycosis fungoides

Wain

Orchard

Whittaker

et al. 2003

Cancer

136

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“…Although CTCL in general and MF in particular are usually observed in middle to late adulthood and are rarely seen before the age of 30 [18], there has been increased recognition that MF (including Sézary syndrome) may arise in children and adolescents, with younger adults reporting onset of symptoms during adolescence [22, 23, 24, 25, 26, 27]. …”

Section: Incidencementioning

confidence: 99%

Mycosis fungoides: Review of Epidemiological Observations

Suárez-Varela¹,

González²,

Vila

et al. 2000

Dermatology

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Background: Mycosis fungoides (MF) is a chronic cutaneous T-cell lymphoma characterized by small cells with cerebriform nuclei that usually express a mature peripheral T-helper cell (CD4+) immunophenotype. Its evolution is typically quite slow, with years between the first manifestations and development of advanced stages of disease. Objective: The purpose of the present paper is to contribute to the material about MF already present in the literature. The review articles that have appeared to date fundamentally address the morphological characteristics, diagnostic criteria and treatment of the disease; in contrast, the present study centers on the evolution of the incidence of MF and on the knowledge of the possible risk factors implicated in its development. Methods: Review of published papers about MF epidemiology. Results: The evidence suggests that the incidence is increasing, but this may be artifactual due to improved diagnostic techniques. The risk of MF is limited to gender and race, being higher in males and in blacks. Survival is highly stage dependent, but 90% of patients survive 15 years with only 10% of cutaneous involvement. Few risk factors have been identified, but several studies have found an association with industrial exposure, particularly to oils. Conclusion: MF is a rare disease and its risk factors have not been studied in any great detail. A European case-control study in progress will substantially increase the evidence available and progress towards identifying a prevention strategy.

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“…Although it is mostly seen in older adults, MF also occurs in patients younger than 40 years, with similar clinical findings and course. 3,4 The incidence of MF is consistently higher in Caucasian than in African American (AA) populations; however, AA patients with MF have a worse prognosis than other ethnic groups. 5 Considering age, sex, and ethnic group, young AA women are among the least likely to develop MF, although their cases are likely to be more severe.…”

mentioning

confidence: 99%