Mycoplasmas and recurrent oral ulceration

Gordon, Alan G.; Dick, HeatherM.; Mason, David R.; Manderson, W.G.; Crichton, W. B.

doi:10.1136/jcp.20.6.865

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…This is in agreement with BARILE et al (1968) and supports the previous conclusion that there is nO' evidence of an etiologic relationship between oral mycopiasmas and RAU (GORDON et al 1967).…”

Section: Discus8ionsupporting

confidence: 92%

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Microorganisms in recurrent aphthous ulcerations

Donatsky

Justesen

Lind

et al. 1977

European J Oral Sciences

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Qualitative and quantitative examinations of the cultivable bacterial flora in biopsies irom recurrent aphthous ulcerations (RAU), experimental oral ulcerations (EOU), and nonnal oral mucosa (NOM) were carried out under aerobic and continuous anaerobic conditions. An attempt was made to culture yeasts, mycoplasma, and virus from the biopsies of RAU, which were also tested for the presence of herpes virus antigen by the fluoicsceiit atitibody method. The predominant bacteria recovered in RAU were ahcniolytic streptococci, coagulase-negative staphylococci, and Neisseria. In EOU the main recoveries were a-hemolytic streptococci, Corynsbacterium, Veillonella, Neisseria, and ilaemophitus. In NOM a-hemolytic streptococci dominated the cultures. Yeasts were only cultured from one patient with RAU. No mycopiasmas or viruses were isolated, nor was herpes virus antigen demonstrated in any of the RAU specimens. The role of the inicnjor,g,anisnis in the pathogenesis of RAU is discussed.

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Section: Discus8ionsupporting

confidence: 92%

“…(1968) no mycopiasmas were isolated from RAU. Furthermore, GORDON, DICK, MASON, MANDERSON, CHRICHTON (1967) were unable to deniotistrate any differences in the occurrence of mycopiasmas or antibodies against mycopiasmas between patients with RAU and controls.…”

mentioning

confidence: 86%

Microorganisms in recurrent aphthous ulcerations

Donatsky

Justesen

Lind

et al. 1977

European J Oral Sciences

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“…On the basis of this significant correlation between the presence of M. salivarium and periodontal disease, it is speculated that the organism might participate in periodontal disease 6 . Mycoplasma also isolated from 27 out of 45 patients with inflammatory oral ulcers, mainly aphthus ulcers, Gordon et al 14 found that mycoplasmas were isolated from the saliva of 15 of the 33 patients with recurrent ulcers, and from the saliva of eight out of 39 healthy controls. In both groups, M. orale was the species Most commonly recovered.…”

Section: Discussionmentioning

confidence: 99%

The Role of Mycoplasmas in Oro-Dental Diseases

Saeed¹,

AL-Ghizawi²

2014

Basrah Journal of Surgery

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This study aimed to isolate mycoplasmas from oral cavity of patients with oro-dental diseases, to evaluate their role in pathogenesis of these diseases, and to evaluate the effects of some antibiotics on them. The population enrolled in this study was individuals attending the dental outpatient clinics in the dental specialty center in Basrah, from private dental clinic, and from otolaryngology outpatient clinic. It consisted of 154 patients with periodontal diseases (gingival diseases & periodontal abscesses) and oral ulcers of different types, in addition to that, 50 healthy subjects were included as control group. It included 112 males and 92 females, their age ranged from 6 to 68 years. This study extended from the period between August 2010 to December 2011. Samples from gingival sulcus or periodontal spaces were obtained by using paper points and swabs from ulcer surface, all specimens were cultured within one hours of sampling. For the isolation of mycoplasma, each specimen was directly inoculated into the liquid phase of MDCS. Mycoplasma spp. were isolated from 120 individuals out of 204 enrolled in this study, males affected more than females, the commonly affected age group was 20-29 years. Smoking play a clear role in causation of dental diseases and mycoplasma found more in smoker patients, (62 were smokers, 36 were non-smokers).Gingival diseases were commonly presented (62 patients), followed by inflammatory oral ulcers (45 patients). Mycoplasma salivarium was the frequently isolated species (70.8%), followed by mycoplasma orale (isolated from 16.6%). Single mycoplasma infection was found in 4 cases, 3 in gingival diseases which were 2 mycoplasma salivarium and one M.orale. The last spp. was M. pneumoniae, it was isolated from periodontal abscess. Tertracycline and erythromycin showed good inhibitory effects against mycoplasmas. In conclusion, Mycoplasma isolated from males with oro dental diseases more than females. The mostly affected age group was 20-29 years of age. Mycoplasma salivarium was the commonest isolated species, followed by mycoplasma orale. It is rare to find single mycoplasma infection in the oral cavity, just 4 cases were documented from total 98 patients. Tetracycline and erythromycin can significantly inhibit the growth of mycoplasma.

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“…While edentulism is theoretically expected to be associated with less oral infection risk, the negative impact on oral and general health is enormous [ 31 ]. The role of complete edentulism as a possible risk factor for actinomycosis has not been well studied, even though limited association has been suggested for mycoplasma and a few other infections [ 32 , 33 ]. Further studies to explore such possible association is recommended.…”

Section: Discussionmentioning

confidence: 99%

“Holes” in the Jaw—A Report of Two Cases of Periapical Actinomycosis

Ayoade

Olayiwola

2018

Diseases

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Periapical actinomycosis is a relatively rare form of cervicofacial actinomycosis, which typically involves the periapical region with subsequent potential spread to the jaw bones. We hereby present two cases of periapical actinomycosis. Both patients presented with jaw pain and “holes” in their gum and lacked the characteristic clinical features commonly seen in cervicofacial actinomycosis such as jaw mass, draining ulcers, sinuses and fistulae. The first patient was an immunocompetent host with chronic stable medical conditions but with a rather bad dentition requiring multiple recent teeth extractions. The second patient was edentulous, had refractory multiple myeloma, was on low-dose chronic steroids and pomalidomide therapy and therefore relatively immunocompromised. Both cases of actinomycosis were diagnosed by jaw bone histopathology, which showed characteristic sulfur granules and embedded Actinomyces-like organisms. The two patients had excellent clinical response to six months of penicillin therapy without any need for surgical intervention. The cases remind clinicians of including actinomycosis in the differential diagnosis of periapical lesions and illustrates the possibility of achieving cure with non-surgical treatment.

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Mycoplasmas and recurrent oral ulceration

Cited by 14 publications

References 35 publications

Microorganisms in recurrent aphthous ulcerations

Microorganisms in recurrent aphthous ulcerations

The Role of Mycoplasmas in Oro-Dental Diseases

“Holes” in the Jaw—A Report of Two Cases of Periapical Actinomycosis

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