Mycoplasma bovis

Maunsell, Fiona P.; Chase, Christopher

doi:10.1016/j.cvfa.2019.08.003

Cited by 29 publications

(17 citation statements)

References 76 publications

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“…In Belgium, 100% of the veal farms are seropositive for M. bovis [5,6], whereas M. bovis is involved in 33% of acute pneumonia outbreaks in beef and dairy farms [7]. Treatment of M. bovis is frequently unsatisfactory, probably due to a combination of intrinsic and acquired antimicrobial resistance, immuno-evasive properties of the pathogen and failure of the animal to generate an effective immune response [8,9]. Together with the absence of an effective commercially available vaccine, the control of M. bovis is particularly challenging.…”

Section: Introductionmentioning

confidence: 99%

Phylogenomic analysis of Mycoplasma bovis from Belgian veal, dairy and beef herds

Bokma

Vereecke

Bleecker³

et al. 2020

Vet Res

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M. bovis is one of the leading causes of respiratory disease and antimicrobial use in cattle. The pathogen is widespread in different cattle industries worldwide, but highest prevalence is found in the veal industry. Knowledge on M. bovis strain distribution over the dairy, beef and veal industries is crucial for the design of effective control and prevention programs, but currently undocumented. Therefore, the present study evaluated the molecular epidemiology and genetic relatedness of M. bovis isolates obtained from Belgian beef, dairy and veal farms, and how these relate to M. bovis strains obtained worldwide. Full genomes of one hundred Belgian M. bovis isolates collected over a 5-year period (2014–2019), obtained from 27 dairy, 38 beef and 29 veal farms, were sequenced by long-read nanopore sequencing. Consensus sequences were used to generate a phylogenetic tree in order to associate genetic clusters with cattle sector, geographical area and year of isolation. The phylogenetic analysis of the Belgian M. bovis isolates resulted in 5 major clusters and 1 outlier. No sector-specific M. bovis clustering was identified. On a world scale, Belgian isolates clustered with Israeli, European and American strains. Different M. bovis clusters circulated for at least 1.5 consecutive years throughout the country, affecting all observed industries. Therefore, the high prevalence in the veal industry is more likely the consequence of frequent purchase from the dairy and beef industry, than that a reservoir of veal specific strains on farm would exist. These results emphasize the importance of biosecurity in M. bovis control and prevention.

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Section: Introductionmentioning

confidence: 99%

Phylogenomic analysis of Mycoplasma bovis from Belgian veal, dairy and beef herds

Bokma

Vereecke

Bleecker³

et al. 2020

Vet Res

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“…It is well known that MP causes a significant increase in pro-inflammatory factors TNF-α and IL-1β ( Liu et al., 2018 ; Maunsell and Chase, 2019 ; Luo et al., 2021 ). As early as 2003, TNF- α has been shown to increase the expression, adhesion and extravasation of Cx43 in monocytes/macrophages ( Eugenín et al., 2003 ; Véliz et al., 2008 ).…”

Section: Establishment Of Gap Junction Between Ams and Aecs During Mp...mentioning

confidence: 99%

Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection

Xue

Wang

Han

2023

Front. Cell. Infect. Microbiol.

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Mycoplasma pneumoniae, as one of the most common pathogens, usually causes upper respiratory tract infections and pneumonia in humans and animals. It accounts for 10% to 40% of community-acquired pneumonia in children. The alveolar epithelial cells (AECs) are the first barrier against pathogen infections, triggering innate immune responses by recruiting and activating immune cells when pathogens invade into the lung. Alveolar macrophages (AMs) are the most plentiful innate immune cells in the lung, and are the first to initiate immune responses with pathogens invasion. The cross-talk between the alveolar epithelium and macrophages is necessary to maintain physiological homeostasis and to eradicate invaded pathogen by regulating immune responses during Mycoplasma pneumoniae infections. This review summarizes the communications between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infections, including cytokines-medicated communications, signal transduction by extracellular vesicles, surfactant associated proteins-medicated signal transmission and establishment of intercellular gap junction channels.

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“…IgG is important for virus and toxin neutralization and bacterial agglutination and opsonization. In cattle, IgG1 is known to be a less potent opsonin than IgG2 (32). IgM is a pentameric molecule important for bacterial agglutination, complement fixation and opsonization and is more restricted to intravascular spaces because of its size.…”

Section: Adaptive Immune Responsementioning

confidence: 99%

Bovine Immunology: Implications for Dairy Cattle

Vlasova

Saif

2021

Front. Immunol.

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The growing world population (7.8 billion) exerts an increased pressure on the cattle industry amongst others. Intensification and expansion of milk and beef production inevitably leads to increased risk of infectious disease spread and exacerbation. This indicates that improved understanding of cattle immune function is needed to provide optimal tools to combat the existing and future pathogens and improve food security. While dairy and beef cattle production is easily the world’s most important agricultural industry, there are few current comprehensive reviews of bovine immunobiology. High-yielding dairy cattle and their calves are more vulnerable to various diseases leading to shorter life expectancy and reduced environmental fitness. In this manuscript, we seek to fill this paucity of knowledge and provide an up-to-date overview of immune function in cattle emphasizing the unresolved challenges and most urgent needs in rearing dairy calves. We will also discuss how the combination of available preventative and treatment strategies and herd management practices can maintain optimal health in dairy cows during the transition (periparturient) period and in neonatal calves.

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Mycoplasma bovis

Cited by 29 publications

References 76 publications

Phylogenomic analysis of Mycoplasma bovis from Belgian veal, dairy and beef herds

Phylogenomic analysis of Mycoplasma bovis from Belgian veal, dairy and beef herds

Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection

Bovine Immunology: Implications for Dairy Cattle

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