Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis

Abstract

SUMMARYThe relationship between mycoplasma and ureaplasma infection and male infertility has been studied widely; however, results remain controversial. This meta-analysis investigated the association between genital ureaplasmas (Ureaplasma urealyticum, Ureaplasma parvum) and mycoplasmas (Mycoplasma hominis, Mycoplasma genitalium), and risk of male infertility. Differences in prevalence of ureaplasma and mycoplasma infection between China and the rest of the world were also compared. Study data were collected from PubMed, Embase and the China National Knowledge Infrastructure. Summary odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing and publication bias testing were also performed. A total of 14 studies were used: five case-control studies with 611 infertile cases and 506 controls featuring U. urealyticum infection, and nine case-control studies with 2410 cases and 1223 controls concerning M. hominis infection. Two other infection (U. parvum and M. genitalium) were featured in five and three studies, respectively. The meta-analysis results indicated that U. parvum and M. genitalium are not associated with male infertility. However, a significant relationship existed between U. urealyticum and M. hominis and male infertility. Comparing the global average with China, a significantly higher positive rate of U. urealyticum, but a significantly lower positive rate of M. hominis, was observed in both the infertile and control groups in China.

Prevalence of sexually transmitted diseases among men from infertile couples

“…Согласно результатам метаанализа 14 иссле-дований, U. parvum и M. genitalium не вызывают бесплодия у мужчин в отличие от U. urealyticum и M. hominis, способных к адгезии и дестабилиза-ции мембран сперматозоидов [23]. Поэтому, не-смотря на обнаруженную нами сравнительно вы-сокую частоту встречаемости микоплазменной и уреаплазменной инфекций, применение мето-дов диагностики, регламентированных порядком использования ВРТ, не позволило нам отличить пациентов, нуждающихся в восстановлении ре-продуктивного здоровья, от мужчин -носителей условно-патогенных микроорганизмов, не оказы-вающих негативного влияния на фертильность.…”

Molecular Study for Diagnosis of Ureaplasma parvum in Women with Recurrent Miscarriage

“…Since those days, numerous clinical studies have been performed in an attempt to clarify what roles, if any, these organisms play as agents responsible for invasive infections in neonates, premature labor, spontaneous miscarriage, stillbirth, and chronic lung disease of prematurity [6].…”

“…U. parvum may play important role in pregnancy and eliciting conditions associated with prematurity [21]. The main aim of this study is to investigate the occurrence of U. parvum in women with recurrent abortion and to determine the distribution of U. parvum serovars (1,3,6,14) in women with recurrent abortion by conventional polymerase chain reaction (PCR) technique.…”

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AbstractThe objects of study is concerted to investigate the occurrence of Ureaplasma parvum in women with recurrent abortion and to determine the distribution of U. parvum serovars (1,3,6,14) in women with recurrent abortion by conventional polymerase chain reaction (PCR) technique. In total, 130 samples included vaginal bleeding, vaginal swab, and urine, were collected from women with recurrent abortion and 40 samples included vaginal swab and urine from control women without recurrent abortion.

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“…The positive isolates for Ureaplasma spp. were investigated by conventional PCR technique for identification of U. parvum and subtyping to their serovars (1,3,6,14). The results revealed the U. parvum was identified in 29.6% from patient group and 11% from the control group.…”