Mycophenolate and SARS‐CoV‐2 vaccination: Mixing oil and water

Abstract

Forest plot diagram illustrating the likelihood of seroconversion after vaccination against SARS-CoV-2 among 11 observational studies performed in solid organ transplant recipients (n = 2694), which compared patients receiving mycophenolate-containing and mycophenolate-free immunosuppression regimes in opposite arms F I G U R E 2 Forest plot diagram illustrating the likelihood of seroconversion after vaccination against SARS-CoV-2 among four observational studies performed in liver transplant patients (n = 655), which compared patients receiving mycophenolate-containing and mycophenolate-free immunosuppression regimes in opposite arms

SARS-CoV-2 vaccination in liver transplant recipients: We still haven't found what we are looking for

“…A recent meta-analysis evaluated the relationship between MMF and seroconversion after SARS-CoV-2 immunization in SOT recipients. ໿When the analysis was restricted to studies performed in LTR, the negative effect of MMF was consistent (OR=0.46; 95%CI 0.31–0.68; p<.001) [14] . In some studies, a dose-dependent impairment of the humoral response was observed, particularly when the daily dose of MMF was higher than 1000 mg per day [ 12 , 14 ].…”

“…໿When the analysis was restricted to studies performed in LTR, the negative effect of MMF was consistent (OR=0.46; 95%CI 0.31–0.68; p<.001) [14] . In some studies, a dose-dependent impairment of the humoral response was observed, particularly when the daily dose of MMF was higher than 1000 mg per day [ 12 , 14 ]. The detrimental effects of an MMF-containing immunosuppressive regimen in the vaccination induced humoral immune response was also described in SOT recipients after vaccination against the influenza virus [15] .…”