Mycobacterium marinum lymphocutaneous infection

Bouceiro-Mendes, Rita; Ortins-Pina, Ana; Fraga, A.; Marques, Thiago da Cruz; Viveiros, Miguel; Machado, Diana; Soares‐de‐Almeida, Luís; Freitas, J. P.; Filipe, Paulo

doi:10.5070/d3252042893

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…As described in the three reported clinical cases, this kind of infection must be considered when key diagnostic elements are present. A high index of suspicion is sustained by the combination of some factors such as a cutaneous lesion with poor response to conventional antibiotic treatments and a history of aquatic exposure (mainly fish farmers and aquarium enthusiasts) [8][9][10].…”

Section: Figure 3: Ulcerated Lesion Located On the Elbow Discussionmentioning

confidence: 99%

“…Regarding treatment, as there are no comparative trials of different treatment regimens and there is no consensus for an adequate duration of therapy, the statement endorsed by the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) regarding diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases from 2007 [ 4 ] is useful for guiding treatment choices. Although spontaneous remission without treatment has been reported in immunocompetent individuals with small lesions, usually combination antibiotic treatment is needed for complete resolution of lesions [ 8 , 10 ]. A reasonable approach is to treat with two active agents until the lesions heal and then for one or two additional months, typically for a three to four-month total period of treatment guided mainly by clinical response and considering both the extension and severity of the infection and the presence of underlying disorders [ 3 , 4 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Human infection is characterized by cutaneous and/or subcutaneous involvement presenting as solitary or multiple nodular or ulcerated lesions, usually on the extremities of the upper limbs such as a finger or the hand [ 3 ]. Lymphangitic dissemination can also occur in a sporotrichosis pattern in up to one-third of cases [ 9 , 10 ]. In immunosuppressed hosts or when there is a delay in diagnosis, M. marinum infection can cause deep structure and invasive disease including tenosynovitis, septic arthritis, or osteomyelitis [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Mycobacterium marinum Cutaneous Infection: A Series of Three Cases and Literature Review

Gonçalves¹,

Furtado²,

Goncąlves³

2022

Cureus

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Mycobacterium marinum is a non-tuberculous mycobacteria present in natural and non-chlorinated bodies of water. It is a known fish pathogen but can also cause human disease. It usually causes cutaneous lesions but in rare cases may originate more invasive diseases with the involvement of deep structures. We describe three cases of patients with cutaneous infection by M. marinum evaluated in a tertiary care center, two with confirmed infection and one with a presumptive diagnosis based on clinical and epidemiological features. A brief bibliographic review of M. marinum infections is then presented to support the theme. We aim to alert one to the difficulties in establishing the correct diagnosis of this infection, emphasize the importance of a high degree of suspicion for its identification, and review the therapeutic management options.

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Section: Figure 3: Ulcerated Lesion Located On the Elbow Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mycobacterium marinum Cutaneous Infection: A Series of Three Cases and Literature Review

Gonçalves¹,

Furtado²,

Goncąlves³

2022

Cureus

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“…Mycobacterium marinum is a nontuberculous mycobacterium (NTM) that lives in fresh or salt water with worldwide distribution. 1 It causes infections in fish and can also cause cutaneous infections in humans. 2 Human infection follows contact with fish or contaminated water and is often described as "swimming pool granuloma" or "fish tank granuloma".…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, diagnosis of M. marinum infection remains a challenge, with a considerable time delay between onset of symptoms and diagnosis. 1 Recent advances in molecular methods based on PCR technique allow rapid detection of mycobacteria species directly in the clinical sample. However, in extra-pulmonary specimens, there is a lack of sensitivity of conventional PCR techniques as they are mostly paucibacillary in nature.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of LAMP and Nested PCR for the Rapid Diagnosis of Mycobacterium marinum Infection

Feng¹,

Wang²,

Jiang³

et al. 2023

IDR

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Culture of Mycobacterium marinum is very time-consuming, taking several weeks to produce positive results. Seeking rapid and sensitive diagnostic methods for diagnosis can greatly improve patient treatment. Our study aimed to compare the rapid diagnostic abilities of polymerase chain reaction (PCR), nested PCR and loop mediated isothermal amplification (LAMP) of detecting M. marinum in skin samples from patients with M. marinum infection. Methods: A total of 6 M. marinum strains and 6 skin samples with definite diagnosis of M. marinum infection were included in the study. We optimized LAMP performance for detection of M. marinum genomic DNA and confirmed the specificity of the primers. Then, the sensitivity of the LAMP and nested PCR assays were assessed by M. marinum strains and clinical samples. Results: Nested PCR was 10-fold more sensitive than the LAMP assay by serial dilution of M. marinum DNA. PCR positive samples were all positive by LAMP detection of 6 clinical M. marinum strains. Out of 6 clinical skin specimens confirmed as M. marinum infection, 0 (0%), 3 (50%), 3 (50%), and 4 (66.6%) were positive by PCR, nested PCR, LAMP and culture. The LAMP shared the same sensitivity than nested PCR in M. marinum strains and clinical samples, but it was easy to perform and faster than nested PCR assay. Conclusion: Compared with conventional PCR, LAMP and nested PCR are more sensitive and have a higher detection rate of M. marinum in clinical skin specimens. The LAMP assay proved to be more suitable for rapid diagnosis of M. marinum infection in a shorter time, especially in resource-limited settings.

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