Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review

Chang, Hao-Yun; Tsai, Wan‐Chen; Lee, Tai-Fen; Sheng, Wang‐Huei

doi:10.1016/j.jfma.2020.06.029

Cited by 17 publications

(9 citation statements)

References 32 publications

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“…Also, it was previously reported in Egypt [ 17 ]. Although it is rare and less virulent than other NTM, a recent study describes M. gordonae in a series of 7 immunocompetent and immunocompromised patients [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Detection of Mycobacterium tuberculosis and Atypical Mycobacteria by DNA-Microarray in Egypt

et al. 2022

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Background and Objectives: Immunocompromised patients are considered a high-risk group to develop mycobacterial infections with either pulmonary and/or extra-pulmonary diseases. Low-cost and low-density (LCD) DNA-microarray is considered an easy and efficient method to detect typical and atypical Mycobacterial species. Materials and methods: Thirty immunocompromised patients were recruited to provide their clinical specimens (sputum, serum, urine and lymph node aspirate). Both Real-Time PCR and LCD-microarray techniques were performed and compared to the conventional methods of Ziehl-Neelsen (ZN) staining and Lowenstein Jensen (LJ) culturing. Results and conclusion: Mycobacterium tuberculosis complex (MTBC) was detected in all 30 clinical specimens (100% sensitivity) by Real-Time PCR and LCD-microarray. Additionally, co-infection with 4 atypical species belonging to mycobacteria other than tuberculosis (MOTT) was identified in 7 sputum specimens. These atypical mycobacterial species were presented as M. kansasii 10% (n=3), M. avium complex 6.6% (n=2), M. gordanae 3.3% (n=1) and M. peregnium 3.3% (n=1). This study documents the presence of certain species of atypical mycobacteria among immunocompromised patients in Egypt. To the best of our knowledge, this is the first detection of M. peregenium among clinical specimen in Egypt.

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Section: Discussionmentioning

confidence: 99%

Simultaneous Detection of Mycobacterium tuberculosis and Atypical Mycobacteria by DNA-Microarray in Egypt

et al. 2022

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“…Mycobacterium gordonae is a species of NTM commonly found in water (tap water) and soil 10 . Once it was considered an environmental pathogen that could only cause opportunistic infection in immunocompromised hosts such as HIV‐positive patients 11 . Besides HIV infection, solid organ transplant recipients, corticosteroid use, renal failure requiring long‐term hemodialysis, diabetes, and malignancy are still considered risk factors of M. gordonae infection.…”

Section: Discussionmentioning

confidence: 99%

“…However, despite the characteristic of low virulence of M. gordonae, increasing cases depicting seemingly immunocompetent patient infected by this NTM have been reported worldwide. Occasionally, M. gordonae is found resident in human sputum samples and gastric lavage 11,12 …”

Section: Discussionmentioning

confidence: 99%

A very rare case of mycobacterium gordonae infection of the breast

et al. 2020

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“…Potentially all NTM species can cause skin infections; however, for the slow growing mycobacterium (SGM) M. marinum , the skin is the typical site of infection, and the rapidly growing mycobacteria (RGM) M. fortuitum , M. abscessus and M. chelonae may also give cutaneous disease. MAC complex [ 44 ] and less pathogenic NTM may also determine SSTIs, as reported for M. haemophilum [ 7 , 45 , 46 ], M. gordonae [ 47 ] and M. agri [ 48 ].…”

Section: Mycobacterial Skin Infectionsmentioning

confidence: 99%

Mycobacterial skin infection

Giannotti

Gregori

Matteelli

et al. 2022

Current Opinion in Infectious Diseases

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Purpose of review The aim of this article is to review the most recent evidences concerning mycobacterial skin infections, limiting the period of literature research to 2020--2021. Recent findings Mycobacterial skin infections include a heterogeneous group of cutaneous diseases. Cutaneous tuberculosis is usually the result of hematogenous dissemination or spread from underlying foci and it must be distinguished from tuberculids, resulting from the immunological reaction to Mycobacterium tuberculosis antigens. Leprosy prevalence was drastically reduced after introduction of multidrug therapy in the 1980 s, but cases are still reported due to underdiagnosis, and animal and environmental reservoirs. Recent advances concentrate in the diagnostic field. Specific guidelines for the treatment of nontuberculous mycobacteria skin infections are missing and surgical procedures may be required. Prognosis is better as compared to nontuberculous mycobacteria lung disease. Rapid laboratory-confirmed diagnosis of Buruli ulcer may be achieved by the IS2404 PCR. Among new drugs, telacebec is promising in terms of potency, shorter duration and tolerability in animal studies. A clinical trial in humans is planned. Summary Mycobacterial cutaneous lesions are nonpathognomonic and clinical suspicion must be confirmed by culture or molecular detection. Long-course multidrug treatment is required based on susceptibility tests. Surgical intervention may also be required. Rehabilitation and psychosocial support reduce long-term physical and mental consequences mostly in Buruli ulcer and leprosy.

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Mycobacterium gordonae infection in immunocompromised and immunocompetent hosts: A series of seven cases and literature review

Cited by 17 publications

References 32 publications

Simultaneous Detection of <b><i>Mycobacterium tuberculosis</i></b> and Atypical Mycobacteria by DNA-Microarray in Egypt

Simultaneous Detection of <b><i>Mycobacterium tuberculosis</i></b> and Atypical Mycobacteria by DNA-Microarray in Egypt

A very rare case of mycobacterium gordonae infection of the breast

Mycobacterial skin infection

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