Mycobacterium chelonae–Mycobacterium abscessus complex clear corneal wound infection with recurrent hypopyon and perforation after phacoemulsification and intraocular lens implantation

Servat, Juan Javier; Ramos-Esteban, Jerome C.; Tauber, Shachar; Bia, Frank J.

doi:10.1016/j.jcrs.2004.12.053

Cited by 19 publications

(14 citation statements)

References 21 publications

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“…Moreover, orbital infection has been reported after penetrating injury to the orbit, and after blepharoplasty (40, 41), certainly caused by an exogenous contamination. Several cases of endophthalmitis have been described following eye surgery, intravitreal injections or lens implantations, all procedures probably having been done under non‐sterile conditions (42–46).…”

Section: Soft Tissue Infectionsmentioning

confidence: 99%

Mycobacterium abscessus: an emerging rapid‐growing potential pathogen

Petrini

2006

APMIS

198

189

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Mycobacterium abscessus is the most pathogenic and chemotherapy-resistant rapid-growing mycobacterium. It is commonly associated with contaminated traumatic skin wounds and with post-surgical soft tissue infections. It is also one of the mycobacteria that are most often isolated from cystic fibrosis patients. It is essential to differentiate this species from the formerly indistinct "M. chelonae-complex", as chemotherapy is especially difficult in M. abscessussenso strictu. Clarithromycin or azithromycin are the only regular oral antimycobacterial agents with an effect on M. abscessus, and should preferably be supplemented with other drugs since long-term monotherapy may cause resistance. Amikacin is a major parenteral drug against M. abscessus that should also be given in combination with another drug. The recently introduced drug tigecycline may prove to be an important addition to chemotherapy, but has yet to be fully clinically evaluated as an antimycobacterial agent. Surgery can be curative, or at least helpful, in the healing of M. abscessus infection, and if conducted, it should include the removal of all foreign or necrotic material. There is increasing awareness of M. abscessus as an emerging pathogen.

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Section: Soft Tissue Infectionsmentioning

confidence: 99%

Mycobacterium abscessus: an emerging rapid‐growing potential pathogen

Petrini

2006

APMIS

198

189

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“…Tuberculosis is considered one of the great masqueraders; because the purified protein derivative test demonstrated 15 mm of erythema although TB gold was not available for her at that point, the patient was started on antituberculosis drugs, including ethambutol, rifampin and isoniazid. Infection by Mycobacterium has been reported after laser‐assisted in situ keratomileusis, extracapsular cataract surgery, endokeratoplasty and intravitreal injection 8,9 . There is only one reported case of Mycobacterium chelonae – Mycobacterium abscessus complex corneal wound infection after phacoemulsification and intraocular lens implantation 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Corneal infections are predisposed by various factors, eyelid abnormalities, tear film instability and inappropriate use of topical corticosteroids and/or antibiotics 8 . Infection by Mycobacterium has been reported after extracapsular cataract surgery 8,9 …”

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confidence: 99%

Severe unilateral corneal melting after uneventful phacoemulsification cataract surgery

Praidou

Brazitikos

Dastiridou

et al. 2013

Clinical and Experimental Optometry

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We present a rare case of severe unilateral corneal melt after uneventful phacoemulsification. A 38-year-old woman presented one week after uneventful phacoemulsification cataract surgery complaining of pain and blurred vision in her operated eye. Our differential diagnosis included peripheral ulcerative keratitis, Mooren's ulcer and herpetic keratitis. The patient was started on oral acyclovir and topical steroids. An extensive blood work-up was done to rule out autoimmune diseases. Purified protein derivative test demonstrated 15 mm of erythema. Because the clinical picture was progressing, the patient was started on triple anti-tuberculosis therapy. Despite treatment, the patient was complaining of excruciating eye pain that was relieved only with intramuscular prednisone injections. The corneal melt healed after approximately three months without any other intervention, leaving a 90 per cent thickness loss in its central area. Idiopathic corneal melt after uneventful phacoemulsification is a rare complication, which must be managed in a multidirectional treatment approach to prevent devastating corneal perforation.

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“…Various mycobacterium species, including Mycobacterium goodii, 1 M. abscessus, 2 and M. chelonae, 3 have been reported, but to the best of our knowledge, M. tuberculosis has not been reported. We report a case of endophthalmitis due to M. tuberculosis (MTB).…”

mentioning

confidence: 88%