Mycobacterium Avium Infection in a Silicone-Injected Breast

Perry, RH; Dp, Jaques; Ms, Lesar; Davis, Jeffrey S.; Hd, Peterson

doi:10.1097/00006534-198501000-00024

Cited by 14 publications

(4 citation statements)

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“…In addition, 8 of 10 specimens that were negative by conventional staining methods were positive with the mixed-antibodies method. Using the same technique, Perry et al (379) showed that the immunohistochemical stain was more sensitive than a Kinyoun stain, 90 versus 66%, with bone marrow core biopsies, but neither of these methods was as sensitive as blood culture. Furthermore, there was a poor correlation between the level of mycobacteremia and the number of bacilli observed by the immunohistochemical stain.…”

Section: Direct Detection By Stainingmentioning

confidence: 99%

The Mycobacterium avium complex

1993

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Mycobacterium avium complex (MAC) disease emerged early in the epidemic of AIDS as one of the common opportunistic infections afflicting human immunodeficiency virus-infected patients. However, only over the past few years has a consensus developed about its significance to the morbidity and mortality of AIDS. M. avium was well known to mycobacteriologists decades before AIDS, and the MAC was known to cause disease, albeit uncommon, in humans and animals. The early interest in the MAC provided a basis for an explosion of studies over the past 10 years largely in response to the role of the MAC in AIDS opportunistic infection. Molecular techniques have been applied to the epidemiology of MAC disease as well as to a better understanding of the genetics of antimicrobial resistance. The interaction of the MAC with the immune system is complex, and putative MAC virulence factors appear to have a direct effect on the components of cellular immunity, including the regulation of cytokine expression and function. There now is compelling evidence that disseminated MAC disease in humans contributes to both a decrease in the quality of life and survival. Disseminated disease most commonly develops late in the course of AIDS as the CD4 cells are depleted below a critical threshold, but new therapies for prophylaxis and treatment offer considerable promise. These new therapeutic modalities are likely to be useful in the treatment of other forms of MAC disease in patients without AIDS. The laboratory diagnosis of MAC disease has focused on the detection of mycobacteria in the blood and tissues, and although the existing methods are largely adequate, there is need for improvement. Indeed, the successful treatment of MAC disease clearly will require an early and rapid detection of the MAC in clinical specimens long before the establishment of the characteristic overwhelming infection of bone marrow, liver, spleen, and other tissue. Also, a standard method of susceptibility testing is of increasing interest and importance as new effective antimicrobial agents are identified and evaluated. Antimicrobial resistance has already emerged as an important problem, and methods for circumventing resistance that use combination therapies are now being studied.

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Section: Direct Detection By Stainingmentioning

confidence: 99%

The Mycobacterium avium complex

1993

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“…Infection should always be treated immediately and prior to definitive surgery. [611] Magnetic resonance imaging is recommended to confirm silicone deposition and to serve as a baseline for future breast screening. Image-guided biopsy is performed to exclude malignancy and to confirm silicone mastitis.…”

Section: Discussionmentioning

confidence: 99%

“…[1–11] Depending on the areas of injection and migratory pattern of the silicone, skin inflammation and muscle infiltration can also occur. [13–5] Although there is no clear increase risk of breast cancer associated with injected silicone, inflammatory changes hamper detection of malignancy by interfering with breast examination and imaging.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and treatment of surgical management of silicone mastitis

Liu

Lim

2012

J Cutan Aesthet Surg

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Injected liquid silicone continues to be employed by unscrupulous practitioners in many parts of the world for the purpose of breast augmentation. Complications vary; however, inflammation, foreign body reaction, and granuloma formation often lead to painful and disfigured breasts. Furthermore, migrations of silicone to remote tissues cause additional problems. We present a review of cases and propose an updated algorithm for the diagnosis and management silicone mastitis. We describe two representative cases of mastitis cause by injected liquid silicone. Patients uniformly developed inflammation and granuloma formation causing painful and disfigured breasts. Each patient required bilateral mastectomy and breast reconstruction. Although injection of liquid silicone has been condemned by the legitimate medical community for the purpose of breast augmentation, it continues to be illicitly performed and there exists a sizable patient population suffering from the complications of this procedure. Accurate identification requires a high index of suspicion in patients presenting with firm and painful breasts. An aggressive management strategy is recommended in the setting of silicone mastitis due to the risk of obscuring malignancy.

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“…Destacase o caso de ceratite em que o M. fortuitum foi isolado de uma cultura de córnea, mesmo após 06 meses de tratamento com antimicrobianos (BRASIL, 2007a;INFECÇÕES..., 2008). (BRASIL, 2006;2008a) Infecções causadas por MNT (Mycobacterium abscessus) foram identificados em procedimentos cirúrgicos estéticos, como liposucção e lipoescultura (MURILLO et al, 2000); soluções injetáveis como procaína, Lcarnitina, vitamina C e lidocaína (MUNAYCO et al, 2008;BEER;WAIBEL, 2009) e após injeção de silicone em prótese mámaria (PERRY et al, 1985); tratamento de acupuntura (SONG et al, 2006); colocação de piercing mamilar (TRUPIANO et al, 2001); infecções cutâneas após tatuagens (DRAGE et al, 2010). As MNT constituem microrganismos problemáticos em vários setores dos serviços de saúde, sendo associadas com fluídos de hemodiálise (LOWRIE;LEW, 1990) e algumas soluções desinfetantes (NOMURA et al, 2004).…”

Section: Micobactérias Não Tuberculosas (Mnt)unclassified

Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Cabral¹

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Não poderia deixar de dedicar este trabalho em primeiro lugar à meu pai (in memorian), que foi meu incentivo e luta contínua (até a sua morte), para a construção: como pessoa,me provando que podia ser melhor a cada dia, na profissão que optei, que é a essência do cuidar, e nas escolhas pessoais que fiz, mediante seu aprovo, o que por fim, gerou na essência destas palavras o sentimento: o quanto tu me fazes falta e, como é difícil tomar decisões sem consultar tuas sábias palavras. Em segundo plano, completamente em corpo e alma, meu ZEZINHO, não sei expressar em palavras o que vivi e viverei ao teu lado, porém sei agradecer de forma incomensurável seu apoio por palavras, teu carinho, amor e compreensão pela distância e sem contar, é lógico, com seu apoio financeiro. Obrigada por aliviar "um pouquinho" a dor pela perda de um pai memorável que você tanto conheceu e, Viver contigo, lado a lado, por um amor que descobri na dor, me faz lutar por ele a cada dia. À minha mãe, Que cuidará de mim eternamente por seu zelo criterioso, mãe única e amor incondicional. Tentamos superar juntas a ausência do nosso Bartolomeu (papitinho), mas é difícil superar a ausência de um homem culto e sábio. Obrigada pela imensidão do seu amor e o incentivo ETERNO para a formação pessoal e profissional. Aos meus irmãos Eduardo e Pedro, Agradeço o quanto vocês acreditaram em mim, mesmo à distância, porém sei que nossos corações estarão sempre juntos. Como é difícil ficar longe de família. Agradecimentos Especiais A Profa. Dra. Denise de Andrade, pelas louváveis contribuições neste trabalho e para minha construção pessoal, lembro muito bem quando aportei em sua sala, vindo de tão longe, e me recebeu com tanto carinho. Muito obrigada por me ensinar a ser uma pósgraduanda em todos os sentidos..

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Mycobacterium Avium Infection in a Silicone-Injected Breast

Cited by 14 publications

References 0 publications

The Mycobacterium avium complex

The Mycobacterium avium complex

Evaluation and treatment of surgical management of silicone mastitis

Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

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