Mycetoma of thumb caused by Nocardia transvalensis

Nocardia transvalensis/wallacei hindfoot actinomycetoma

“…In 1994, Mirza SH et al reported a patient with right arm involvement of N. transvalensis that was managed successfully by surgical excision of the lesion and treatment with co-trimoxazole [5] . Another case of mycetoma N. transvalensis of the thumb in a farmer was described by Gugnani HC that was successfully treated by oral co-trimoxazole and like our case had microabscesses [27] . Both cases similarly had history of discharging sinuses.…”

Experimental infection of chickens withNocardia asteroidesandNocardia transvalensis

“…Intraperitoneal injection produced a more severe infection than the oral route for both organisms probably because of intra-air sac and/or lung incidental exposure which might have occurred through the former route. All cases of N. transvalensis infection in humans have produced mycetoma (Gugnani et al, 1982). Lesions were produced in the connective tissue of the breast muscle through which the intraperitoneal inoculation was made showing that the organism can cause muscle infection in chickens.…”

“…Hence it was considered of interest to investigate the pathogenic potential of N. asteroides, the common pathogenic species (Emmons et al, 1977) and N. transvalensis, a rarely known pathogenic species (Gugnani et al, 1982) for the domestic fowl.…”

Experimental Actinomycetoma Due to Nocardia transvalensis in Laboratory Mice

“…The strain of N. transvalensis (ATCC No. 2998 I) recovered from a case of mycetoma of the thumb (5) was grown at 370 C in 200 ml quantities of brain heart infusion broth. After 2 weeks of growth, sterile glass beads were introduced into culture flasks which were agitated onarotaryshakerat200rev/ min for lO min.…”

“…N. transvalensis is a rarely recorded pathogenic species of Nocardia known to cause mycetoma (5,9). An earlier study on its pathogenicity reported on its ability to cause progressive infection of internal organs of laboratory mice (6).…”